Zobrazeno 1 - 10
of 457
pro vyhledávání: '"P Ravassard"'
Publikováno v:
Cell Transplantation, Vol 29 (2020)
Since the 1970s, rodent and human insulin-secreting pancreatic beta-cell lines have been developed and found useful for studying beta-cell biology. Surprisingly, although the dog has been widely used as a translational model for diabetes, no canine i
Externí odkaz:
https://doaj.org/article/ee74065502814c8e9c5f1f2179d19940
Autor:
Bruno Blanchi, Marion Taurand, Claire Colace, Sofia Thomaidou, Charlotte Audeoud, Federica Fantuzzi, Toshiaki Sawatani, Sevda Gheibi, Joan Sabadell-Basallote, Fransje W.J. Boot, Thibault Chantier, Aline Piet, Charlotte Cavanihac, Marion Pilette, Adélie Balguerie, Hamza Olleik, Françoise Carlotti, Miriam Ejarque, Malin Fex, Hindrik Mulder, Miriam Cnop, Decio L. Eizirik, Ouardane Jouannot, Anne-Lise Gaffuri, Paul Czernichow, Arnaud Zaldumbide, Raphaël Scharfmann, Philippe Ravassard
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101772- (2023)
Objectives: Readily accessible human pancreatic beta cells that are functionally close to primary adult beta cells are a crucial model to better understand human beta cell physiology and develop new treatments for diabetes. We here report the charact
Externí odkaz:
https://doaj.org/article/2150f4f22a72439bb1a63dbdb430ec0a
Autor:
Maria-Belen Lopez-Herdoiza, Stephanie Bauché, Baptiste Wilmet, Caroline Le Duigou, Delphine Roussel, Magali Frah, Jonas Béal, Gabin Devely, Susana Boluda, Petra Frick, Delphine Bouteiller, Sébastien Dussaud, Pierre Guillabert, Carine Dalle, Magali Dumont, Agnes Camuzat, Dario Saracino, Mathieu Barbier, Gaelle Bruneteau, Phillippe Ravassard, Manuela Neumann, Sophie Nicole, Isabelle Le Ber, Alexis Brice, Morwena Latouche
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The GGGGCC intronic repeat expansion within C9ORF72 is the most common genetic cause of ALS and FTD. This mutation results in toxic gain of function through accumulation of expanded RNA foci and aggregation of abnormally translated dipeptide repeat p
Externí odkaz:
https://doaj.org/article/cf47ec065e0e43cbbe6e3408fa24d68b
Autor:
Emeric Merour, Hatem Hmidan, Corentine Marie, Pierre-Henri Helou, Haiyang Lu, Antoine Potel, Jean-Baptiste Hure, Adrien Clavairoly, Yi Ping Shih, Salman Goudarzi, Sebastien Dussaud, Philippe Ravassard, Sassan Hafizi, Su Hao Lo, Bassem A Hassan, Carlos Parras
Publikováno v:
eLife, Vol 11 (2022)
The differentiation of oligodendroglia from oligodendrocyte precursor cells (OPCs) to complex and extensive myelinating oligodendrocytes (OLs) is a multistep process that involves large-scale morphological changes with significant strain on the cytos
Externí odkaz:
https://doaj.org/article/c032f3eb47ba4b0586ac73356e196c31
Autor:
Hassan Mziaut, Georg Henniger, Katharina Ganss, Sebastian Hempel, Steffen Wolk, Johanna McChord, Kamal Chowdhury, Philippe Ravassard, Klaus-Peter Knoch, Christian Krautz, Jürgen Weitz, Robert Grützmann, Christian Pilarsky, Michele Solimena, Stephan Kersting
Publikováno v:
Molecular Metabolism, Vol 31, Iss , Pp 150-162 (2020)
Objective: MicroRNAs (miRNAs) play an integral role in maintaining beta cell function and identity. Deciphering their targets and precise role, however, remains challenging. In this study, we aimed to identify miRNAs and their downstream targets invo
Externí odkaz:
https://doaj.org/article/6ae76e0ba7294118a29813f7cd000d05
Autor:
Nadia Amanzougaghene, Shahin Tajeri, Samir Yalaoui, Audrey Lorthiois, Valérie Soulard, Audrey Gego, Armelle Rametti, Véronica Risco-Castillo, Alicia Moreno, Maurel Tefit, Geert-Jan van Gemert, Robert W. Sauerwein, Jean-Christophe Vaillant, Philippe Ravassard, Jean-Louis Pérignon, Patrick Froissard, Dominique Mazier, Jean-François Franetich
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Hepatocyte invasion by Plasmodium sporozoites represents a promising target for innovative antimalarial therapy, but the molecular events mediating this process are still largely uncharacterized. We previously showed that Plasmodium falciparum sporoz
Externí odkaz:
https://doaj.org/article/2754b233e983418089572f00cf630310
Akademický článek
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Autor:
Ildem Akerman, Miguel Angel Maestro, Elisa De Franco, Vanessa Grau, Sarah Flanagan, Javier García-Hurtado, Gerhard Mittler, Philippe Ravassard, Lorenzo Piemonti, Sian Ellard, Andrew T. Hattersley, Jorge Ferrer
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108981- (2021)
Summary: Despite the central role of chromosomal context in gene transcription, human noncoding DNA variants are generally studied outside of their genomic location. This limits our understanding of disease-causing regulatory variants. INS promoter m
Externí odkaz:
https://doaj.org/article/282fb6a0abd54a338e19484f6b2bb305
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Induced pluripotent stem cell-derived organoids offer an unprecedented access to complex human tissues that recapitulate features of architecture, composition and function of in vivo organs. In the context of Parkinson's Disease (PD), human midbrain
Externí odkaz:
https://doaj.org/article/25710e4f42504e1a92f2f81fe61a5528
Publikováno v:
Brain Sciences, Vol 12, Iss 2, p 206 (2022)
Understanding the role of the noradrenergic nucleus locus coeruleus (LC) in cognition and behavior is critical: It is involved in several key behavioral functions such as stress and vigilance, as well as in cognitive processes such as attention and d
Externí odkaz:
https://doaj.org/article/b302e35f41b54193bf3e71e752fac238