Zobrazeno 1 - 10
of 63
pro vyhledávání: '"P R Leavitt"'
Autor:
Alissandra de Moura Gomes, Terri L. Petkau, Andrea J. Korecki, Oriol Fornes, Adriana Galvan, Ge Lu, Austin M. Hill, Siu Ling Lam, Anqi Yao, Rachelle A. Farkas, Wyeth W. Wasserman, Yoland Smith, Elizabeth M. Simpson, Blair R. Leavitt
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract Compact cell type-specific promoters are important tools for basic and preclinical research and clinical delivery of gene therapy. In this work, we designed novel MiniPromoters to target D1 and D2 type dopaminoceptive medium spiny neurons in
Externí odkaz:
https://doaj.org/article/ccbb413e18624dfaadafe59f90e06ce7
Autor:
Nicholas S. Caron, Lauren M. Byrne, Fanny L. Lemarié, Jeffrey N. Bone, Amirah E.-E. Aly, Seunghyun Ko, Christine Anderson, Lorenzo L. Casal, Austin M. Hill, David J. Hawellek, Peter McColgan, Edward J. Wild, Blair R. Leavitt, Michael R. Hayden
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-22 (2024)
Abstract Background Therapeutic approaches aimed at lowering toxic mutant huntingtin (mHTT) levels in the brain can reverse disease phenotypes in animal models of Huntington's disease (HD) and are currently being evaluated in clinical trials. Sensiti
Externí odkaz:
https://doaj.org/article/89b2e043ae1a4ef094cfbb9512ed2741
Publikováno v:
Arctic, Antarctic, and Alpine Research, Vol 56, Iss 1 (2024)
ABSTRACTMountain lakes are sensitive indicators of anthropogenically driven global change, with lake sediment records documenting increased primary production during the twentieth century. Atmospheric nutrient deposition and warming have been attribu
Externí odkaz:
https://doaj.org/article/4687c598134a46a49b21b54f46722549
Autor:
Cynthia Soued, Matthew J. Bogard, Kerri Finlay, Lauren E. Bortolotti, Peter R. Leavitt, Pascal Badiou, Sara H. Knox, Sydney Jensen, Peka Mueller, Sung Ching Lee, Darian Ng, Björn Wissel, Chun Ngai Chan, Bryan Page, Paige Kowal
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Inland waters are one of the largest natural sources of methane (CH4), a potent greenhouse gas, but emissions models and estimates were developed for solute-poor ecosystems and may not apply to salt-rich inland waters. Here we combine field
Externí odkaz:
https://doaj.org/article/e4f2c89bca6f4788871459563e95b0be
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Atmospheric warming heats lakes, but the causes of variation among basins are poorly understood. Here, multi-decadal profiles of water temperatures, trophic state, and local climate from 345 temperate lakes are combined with data on lake geo
Externí odkaz:
https://doaj.org/article/e85c6d292ff145be9c1b23493f79b33b
Autor:
Bethany A. Adair, Andrea J. Korecki, Diana Djaksigulova, Pamela K. Wagner, Nina Y. Chiu, Siu Ling Lam, Tess C. Lengyell, Blair R. Leavitt, Elizabeth M. Simpson
Publikováno v:
Ophthalmology and Therapy, Vol 12, Iss 4, Pp 2049-2068 (2023)
Abstract Introduction Aniridia is a rare congenital vision-loss disease caused by heterozygous variants in the PAX6 gene. There is no vision-saving therapy, but one exciting approach is to use CRISPR/Cas9 to permanently correct the causal genomic var
Externí odkaz:
https://doaj.org/article/236a9d7004ac47589a17158051a80833
Autor:
Benjamin Life, Terri L. Petkau, Giuliano N.F. Cruz, Erick I. Navarro-Delgado, Ning Shen, Keegan Korthauer, Blair R. Leavitt
Publikováno v:
Neurobiology of Disease, Vol 182, Iss , Pp 106138- (2023)
Frontotemporal dementia (FTD) is an early onset dementia characterized by neuropathology and behavioural changes. A common genetic cause of FTD is haploinsufficiency of the gene progranulin (GRN). Mouse models of progranulin deficiency have provided
Externí odkaz:
https://doaj.org/article/14216bfcd001432dbedbf9abe076de7e
Progressive alterations in white matter microstructure across the timecourse of Huntington's disease
Autor:
Carlos Estevez‐Fraga, Michael S. Elmalem, Marina Papoutsi, Alexandra Durr, Elin M. Rees, Nicola Z. Hobbs, Raymund A. C. Roos, Bernhard Landwehrmeyer, Blair R. Leavitt, Douglas R. Langbehn, Rachael I. Scahill, Geraint Rees, Sarah J. Tabrizi, Sarah Gregory
Publikováno v:
Brain and Behavior, Vol 13, Iss 4, Pp n/a-n/a (2023)
Abstract Background Whole‐brain longitudinal diffusion studies are crucial to examine changes in structural connectivity in neurodegeneration. Here, we investigated the longitudinal alterations in white matter (WM) microstructure across the timecou
Externí odkaz:
https://doaj.org/article/14760f7b295f464cbc8b231b3d170168
Autor:
J. John Lucido, Todd A. DeWees, Todd R. Leavitt, Aman Anand, Chris J. Beltran, Mark D. Brooke, Justine R. Buroker, Robert L. Foote, Olivia R. Foss, Angela M. Gleason, Teresa L. Hodge, Cían O. Hughes, Ashley E. Hunzeker, Nadia N. Laack, Tamra K. Lenz, Michelle Livne, Megumi Morigami, Douglas J. Moseley, Lisa M. Undahl, Yojan Patel, Erik J. Tryggestad, Megan Z. Walker, Alexei Zverovitch, Samir H. Patel
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionOrgan-at-risk segmentation for head and neck cancer radiation therapy is a complex and time-consuming process (requiring up to 42 individual structure, and may delay start of treatment or even limit access to function-preserving care. Fea
Externí odkaz:
https://doaj.org/article/b0a186e4d81f46cfb58fca481113cd77
Publikováno v:
Current Research in Neurobiology, Vol 5, Iss , Pp 100094- (2023)
A growing body of evidence has implicated progranulin in neurodevelopment and indicated that aberrant progranulin expression may be involved in neurodevelopmental disease. Specifically, increased progranulin expression in the prefrontal cortex has be
Externí odkaz:
https://doaj.org/article/3f8d6fe70d1643a18042d4f2ae19847b