Zobrazeno 1 - 10
of 17
pro vyhledávání: '"P R Bovy"'
Autor:
Dudley E. McMackins, Mihaly V. Toth, Henry E. Dayringer, J. G. Rico, P. R. Bovy, Nancy S. Nicholson, Anita K. Salyers, Beatrice B. Taite, Jeffery Alan Zablocki, Larry P. Feigen, Thomas E. Rogers, Shashidhar N. Rao, Mark E. Zupec, Robert Bruce Garland, Steven Paul Adams, M. Herin, R. J. Lindmark, Foe S. Tjoeng, S.G. Panzer-Knodle, Masateru Miyano
Publikováno v:
Bioorganic & Medicinal Chemistry. 2:881-895
The evolutionary process from the Arg-Gly-Asp-Phe (RGDF) tetrapeptide to potent orally active anti-platelet agents is presented. The RGD sequence is an important component in the recognition of fibrinogen by its platelet receptor GP IIb-IIIa (integri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ff7ca1e73492c493b88cb344c8d089
https://doi.org/10.1016/s0968-0896(00)82038-6
https://doi.org/10.1016/s0968-0896(00)82038-6
Autor:
P. R. Bovy, J. G. Rico
Publikováno v:
Tetrahedron Letters. 34:8015-8018
The novel (2E)-1,1-dimethylethyl-3-(5-pyrimidinyl)-2-propenoate 3 , obtained by Heck coupling between 5-bromopyrimidine and tert-butyl acrylate undergoes nearly quantitative Michael addition in t-butanol saturated with ammonia to the hitherto unknown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a74bb6a323784b2cfb3ff08e63c774a
https://doi.org/10.1016/s0040-4039(00)61438-7
https://doi.org/10.1016/s0040-4039(00)61438-7
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0be592caf8b946de4f5592a1c7185287
https://doi.org/10.1002/chin.199152175
https://doi.org/10.1002/chin.199152175
Autor:
S. D. Burrows, V. M. Corpus, J. T. Collins, P. R. Bovy, Maria A. Palomo, JM O'Neal, Gillian M. Olins, Ellen G. McMahon, K. Koehler
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed954598c91edc101b8d74be81a0b0a1
https://doi.org/10.1002/chin.199145157
https://doi.org/10.1002/chin.199145157
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87b7253f52348da0f4daf5dec7203cd6
https://doi.org/10.1002/chin.199420239
https://doi.org/10.1002/chin.199420239
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1079:23-28
[Phe(F5)8]angiotensin II was synthesized by the solid phase method and purified by reverse-phase HPLC. In rat uterus and rabbit aorta bioassays the analogue had 10 and 50%, respectively, of the contractile activity of angiotensin II and demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ca1a1c061e4bac57d55e6544e3cf10
https://doi.org/10.1016/0167-4838(91)90019-v
https://doi.org/10.1016/0167-4838(91)90019-v
Autor:
P. R. Bovy, Richard L. Simmons
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 29:81-85
A method for the introduction of 125I in a substituted imidazole has been devised. 2-n-Butyl-4(5)-hydroxymethylene imidazole undergoes rapid and selective electrophilic substitution on the ring when treated with a halogenating agent such as, i. a., N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a670f94aa27c5d712e101ecaf889b7a
https://doi.org/10.1002/jlcr.2580290111
https://doi.org/10.1002/jlcr.2580290111
Publikováno v:
European Journal of Medicinal Chemistry. 25:589-594
Semi-peptidic analogues of the angiotensin II (AII) antagonist [Ile8] AII have been prepared by the solid phase method and, for some steps, by synthesis in solution. In the modified analogues 4–15, the N-terminal di- or tripeptidic fragments (Asp-A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2677c62c224a1cf218e4597479b3ef0e
https://doi.org/10.1016/0223-5234(90)90183-4
https://doi.org/10.1016/0223-5234(90)90183-4
Autor:
Maria A. Palomo, Gillian M. Olins, G J Smits, K S Salles, Joan M. O'Neal, P R Bovy, Dennis R. Patton, A. J. Trapani, J P Koepke, Ellen G. Mcmahon
Publikováno v:
Journal of Medicinal Chemistry. 33:1477-1482
A series of analogues of the recently reported angiotensin II (AII) antagonist [Sar1]AII-(1-7)-amide or des-Phe8[Sar1]AII (3) have been prepared by solid-phase synthesis and purified by reverse-phase liquid chromatography. The agonist and antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1df0bc239548aec2e50ed2041de3888
https://doi.org/10.1021/jm00167a030
https://doi.org/10.1021/jm00167a030
Autor:
J A, Zablocki, J G, Rico, R B, Garland, T E, Rogers, K, Williams, L A, Schretzman, S A, Rao, P R, Bovy, F S, Tjoeng, R J, Lindmark
Publikováno v:
Journal of medicinal chemistry. 38(13)
Our initial orally active fibrinogen receptor antagonist benzamidinopentanoyl (BAP) series which was discovered through truncation of our i.v. antiplatelet agent (SC-52012) demonstrated modest oral activity in canine studies (ethyl [5-(4-amindinophen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f8b6ef5701f22716b8436aba26c226
https://pubmed.ncbi.nlm.nih.gov/7608903
https://pubmed.ncbi.nlm.nih.gov/7608903