Zobrazeno 1 - 10
of 181
pro vyhledávání: '"P R, Ortiz De Montellano"'
Publikováno v:
Biosensors, Vol 3, Iss 3, Pp 259-282 (2013)
DosS/DosR is a two-component regulatory system in which DosS, a heme-containing sensor also known as DevS, under certain conditions undergoes autophosphorylation and then transfers the phosphate to DosR, a DNA-binding protein that controls the entry
Externí odkaz:
https://doaj.org/article/1a222810d5e449dc948136c7c86eff93
Publikováno v:
Drug Metabolism Reviews. 36:1-389
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::400e38386165c876b09689f8a2eb9828
https://doi.org/10.1081/dmr-200027024
https://doi.org/10.1081/dmr-200027024
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 5:204-212
CYP119, the first thermophilic P450 enzyme, reacts much more slowly than CYP101 (P450cam) with aryldiazenes to give sigma-bonded aryl-iron complexes. The CYP119 complexes are stable anaerobically at 80 degrees C but are readily oxidized by O2 to give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb10d5100b8277573d39639e108e8838
https://doi.org/10.1007/s007750050364
https://doi.org/10.1007/s007750050364
Publikováno v:
Biochemistry. 37:1839-1847
Little information is available on the active site structure of the CYP4A family of enzymes or the mechanism by which their omega-hydroxylation regiospecificity is enforced. We report here that the E320A, D323E, and E320/D323E mutations decrease the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e87684d33192fda40f7ed47aaed879
https://doi.org/10.1021/bi972458s
https://doi.org/10.1021/bi972458s
Publikováno v:
Chemical Research in Toxicology. 10:618-626
The simultaneous production of superoxide and nitric oxide by stimulated human neutrophils leads to the formation of peroxynitrite, a physiologically important bactericidal agent. We have investigated two possible pathways for the inactivation of ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60efb7184f2044aa5ecf52f5f41e31a
https://doi.org/10.1021/tx960188t
https://doi.org/10.1021/tx960188t
Autor:
J. J. De Voss, Charles S. Craik, Fiona McPhee, P R Ortiz de Montellano, Irwin D. Kuntz, Zhonghua Yu, P. R. Jones, A.L. Burlingame, P. Caldera
Publikováno v:
Journal of the American Chemical Society. 118:5846-5856
Irreversible inhibition of the HIV-1 protease by agents that specifically alkylate its catalytic aspartate residues is a potentially useful approach for circumventing the evolution of HIV strains that are resistant to protease inhibitors. Five halope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6c05e8c9616df92af58936b3f18875f
https://doi.org/10.1021/ja954069w
https://doi.org/10.1021/ja954069w
Autor:
P R Ortiz de Montellano
Publikováno v:
Biochimie. 77:581-593
The reactions of arylhydrazines (ArNHNH2) or aryldiazenes (ArN = NH) with simple iron porphyrins or with hemoproteins that have relatively open active sites, including hemoglobin, myoglobin, cytochrome P450, chloroperoxidase, catalase, prostaglandin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71626d3c23d0c781b305ee1f7ce1e3eb
https://doi.org/10.1016/0300-9084(96)88174-0
https://doi.org/10.1016/0300-9084(96)88174-0
Publikováno v:
Journal of Biological Chemistry. 269:29553-29556
Previous studies have established that reaction of the rat heme-heme oxygenase complex with H2O2 proceeds normally to give verdoheme, whereas reaction of the complex with meta-chloroperbenzoic acid yields a ferryl (FeIV = O) species and a protein rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5909be79430901a9a78632102734e5d
https://doi.org/10.1016/s0021-9258(18)43915-4
https://doi.org/10.1016/s0021-9258(18)43915-4
Publikováno v:
Journal of Biological Chemistry. 269:28815-28821
Earlier studies have shown that the reactions of cytochrome P450 with arylhydrazines yield aryl-iron complexes, and that oxidative migration of the aryl groups to the pyrrole nitrogens of the heme provides information on the active site topology. Com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9500142c6e3719c3fc98ab140274f024
https://doi.org/10.1016/s0021-9258(19)61979-4
https://doi.org/10.1016/s0021-9258(19)61979-4
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 266:H1879-H1885
The present study evaluated the effects of cytochrome P-450 inhibitors on the response of the renal microvasculature to changes in renal perfusion pressure and on autoregulation of glomerular capillary pressure using the rat juxtamedullary nephron mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28c93dc246b093e0befd29d3cee4c65
https://doi.org/10.1152/ajpheart.1994.266.5.h1879
https://doi.org/10.1152/ajpheart.1994.266.5.h1879