Zobrazeno 1 - 10
of 15
pro vyhledávání: '"P R, Odgren"'
Autor:
Liang Ye, Leslie R Morse, Li Zhang, Hajime Sasaki, Jason C Mills, Paul R Odgren, Greg Sibbel, James R L Stanley, Gee Wong, Ariane Zamarioli, Ricardo A Battaglino
Publikováno v:
PLoS Genetics, Vol 11, Iss 3, p e1005057 (2015)
Mutations in sorting nexin 10 (Snx10) have recently been found to account for roughly 4% of all human malignant osteopetrosis, some of them fatal. To study the disease pathogenesis, we investigated the expression of Snx10 and created mouse models in
Externí odkaz:
https://doaj.org/article/dc48f1718502453495e1c1359304b645
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127537 (2015)
Plekhm1 is a large, multi-modular, adapter protein implicated in osteoclast vesicle trafficking and bone resorption. In patients, inactivating mutations cause osteopetrosis, and gain-of-function mutations cause osteopenia. Investigations of potential
Externí odkaz:
https://doaj.org/article/e182619297154c30a99bcec6862650bc
Autor:
Hanna Witwicka, Sung-Yong Hwang, Pablo Reyes-Gutierrez, Hong Jia, Paul E Odgren, Leah Rae Donahue, Mark J Birnbaum, Paul R Odgren
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128275 (2015)
The fusion of monocyte/macrophage lineage cells into fully active, multinucleated, bone resorbing osteoclasts is a complex cell biological phenomenon that utilizes specialized proteins. OC-STAMP, a multi-pass transmembrane protein, has been shown to
Externí odkaz:
https://doaj.org/article/73882b023b3642ad816a40ca46f87713
Autor:
Paul R Odgren, Craig H Pratt, Carole A Mackay, April Mason-Savas, Michelle Curtain, Lindsay Shopland, Tsutomu Ichicki, John P Sundberg, Leah Rae Donahue
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9959 (2010)
Investigations of naturally-occurring mutations in animal models provide important insights and valuable disease models. Lamins A and C, along with lamin B, are type V intermediate filament proteins which constitute the proteinaceous boundary of the
Externí odkaz:
https://doaj.org/article/04d0b116581b4ecdac5a1de4002ff341
Autor:
B Guo, P R Odgren, A J van Wijnen, T J Last, J Nickerson, S Penman, J B Lian, J L Stein, G S Stein
Publikováno v:
Proceedings of the National Academy of Sciences. 92:10526-10530
NMP-1 was initially identified as a nuclear matrix-associated DNA-binding factor that exhibits sequence-specific recognition for the site IV regulatory element of a histone H4 gene. This distal promoter domain is a nuclear matrix interaction site. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0588cdd4a9065a2b70dc4f2c92146f30
https://doi.org/10.1073/pnas.92.23.10526
https://doi.org/10.1073/pnas.92.23.10526
Autor:
S C, Marks, C, Lundmark, C, Christersson, T, Wurtz, P R, Odgren, M F, Seifert, C A, Mackay, A, Mason-Savas, S N, Popoff
Publikováno v:
The International journal of developmental biology. 44(3)
The pacemaker of endochondral bone growth is cell division and hypertrophy of chondrocytes. The developmental stages of chondrocytes, characterized by the expression of collagen types II and X, are arranged in arrays across the growth zone. Mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b442fc72dcfd28909464d069a4d2e8d7
https://pubmed.ncbi.nlm.nih.gov/10853827
https://pubmed.ncbi.nlm.nih.gov/10853827
Autor:
J, Xu, S L, Smock, F F, Safadi, A B, Rosenzweig, P R, Odgren, S C, Marks, T A, Owen, S N, Popoff
Publikováno v:
Journal of cellular biochemistry. 77(1)
The mammalian osteopetroses represent a pathogenetically diverse group of skeletal disorders characterized by excess bone mass resulting from reduced osteoclastic bone resorption. Abnormalities involving osteoblast function and skeletal development h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5de6aa9eb33f0ae4ab6f8445adb7c7d8
https://pubmed.ncbi.nlm.nih.gov/10679821
https://pubmed.ncbi.nlm.nih.gov/10679821
Publikováno v:
Annals of the Academy of Medicine, Singapore. 28(5)
The craniofacial skeleton develops from a base in which coordinated growth at sutures and growth centres assures the development of normal form. In this report we describe features of retarded postnatal craniofacial development in the osteopetrotic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7ce9c914ab525eed1f6ca8109321b00
https://pubmed.ncbi.nlm.nih.gov/10597348
https://pubmed.ncbi.nlm.nih.gov/10597348
Publikováno v:
Developmental dynamics : an official publication of the American Association of Anatomists. 215(2)
The toothless (osteopetrotic) mutation in the rat is characterized by retarded development of the anterior facial skeleton. Growth of the anterior face in rats occurs at the premaxillary-maxillary suture (PMMS). To identify potential mechanisms for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::957fdf3517cf955196da5a558a9f8eab
https://pubmed.ncbi.nlm.nih.gov/10373016
https://pubmed.ncbi.nlm.nih.gov/10373016
Publikováno v:
Journal of cellular biochemistry. 67(4)
The molecular mechanisms that mediate the transition from an osteoprogenitor cell to a differentiated osteoblast are unknown. We propose that topoisomerase II (topo II) enzymes, nuclear proteins that mediate DNA topology, contribute to coordinating t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c02d91428b6bf7138dd29bc4d17f58e7
https://pubmed.ncbi.nlm.nih.gov/9383705
https://pubmed.ncbi.nlm.nih.gov/9383705