Zobrazeno 1 - 10
of 11
pro vyhledávání: '"P R, Harbach"'
Autor:
P. R. Harbach, E. Edewaard, P. Varlan, Lisa Turner, Scott D. Jewell, Eric Collins, Eric Hudson, Bree Berghuis, Galen Hostetter, Kristin Feenstra, James H. Resau
Publikováno v:
Veterinary pathology. 51(1)
Animal models have historically informed veterinary and human pathophysiology. Next-generation genomic sequencing and molecular analyses using analytes derived from tissue require integrative approaches to determine macroanalyte integrity as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6c4d769e43f979748b0d609895e7f2
https://pubmed.ncbi.nlm.nih.gov/24227009
https://pubmed.ncbi.nlm.nih.gov/24227009
Publikováno v:
Environmental and molecular mutagenesis. 33(3)
We compared the lambda cII/cI transgenic mutation assay described by Jakubczak et al. [(1996): Proc Natl Acad Sci USA 93:9073-9078] to the previously established Big Blue assay. Genomic DNA isolated from liver, spleen, and lung tissue of control or e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::99a8f49fff6295f24c353dc89eb361e9
https://pubmed.ncbi.nlm.nih.gov/10334627
https://pubmed.ncbi.nlm.nih.gov/10334627
Publikováno v:
Environmental and molecular mutagenesis. 33(2)
We tested the ability of a series of known genotoxic agents to cause mutations at the hprt locus in peripheral blood T-lymphocytes of cynomolgus monkeys as measured by the ability to form clones in the presence of 6-thioguanine. Ethylmethane sulfonat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::211633d49cc77820baa7149946172c51
https://pubmed.ncbi.nlm.nih.gov/10217066
https://pubmed.ncbi.nlm.nih.gov/10217066
Publikováno v:
Environmental and molecular mutagenesis. 33(2)
Big Blue mice harbor a recoverable transgene in a lambda/LIZ shuttle vector. In the standard assay, in vivo mutations are measured in the bacterial lacI gene using a labor-intensive color plaque assay. Applying a simpler assay [Jakubczak et al. (1996
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c6c7cdb6cf430527c2f4b5e70a2c59fc
https://pubmed.ncbi.nlm.nih.gov/10217067
https://pubmed.ncbi.nlm.nih.gov/10217067
Publikováno v:
Environmental and molecular mutagenesis. 33(1)
We have been studying in vivo mutagenesis at the hypoxanthine phosphoribosyl transferase (hprt) locus in cynomolgus monkey T-lymphocytes. This primate model allows us to study mutations and their kinetics under well-controlled conditions. Previously,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba42ac014d7bb36f12460752bc35af15
https://pubmed.ncbi.nlm.nih.gov/10037322
https://pubmed.ncbi.nlm.nih.gov/10037322
Publikováno v:
Environmental and molecular mutagenesis. 32(4)
We examined several experimental parameters of the lambda cI/cII transgenic mutation assay. In the assay, clear plaque lambda phage mutants are identified in a positive selection scheme following rescue of the lambda/LIZ shuttle vector from frozen ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::679815f0edcf97a6738a0604729f4a70
https://pubmed.ncbi.nlm.nih.gov/9882006
https://pubmed.ncbi.nlm.nih.gov/9882006
Autor:
Z, Zhao, K A, Koeplinger, G E, Padbury, M J, Hauer, G L, Bundy, L S, Banitt, T M, Schwartz, D C, Zimmermann, P R, Harbach, J K, Mayo, C S, Aaron
Publikováno v:
Chemical research in toxicology. 9(8)
U-89843 is a novel pyrrolo[2,3-d]pyrimidine antioxidant with prophylactic activity in animal models of lung inflammation. During preclinical safety evaluation, U-89843 was found to give a positive response in the in vitro unscheduled DNA synthesis (U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b0d73d329f6bb628483afbc4c0cecfb
https://pubmed.ncbi.nlm.nih.gov/8951224
https://pubmed.ncbi.nlm.nih.gov/8951224
Publikováno v:
Environmental and molecular mutagenesis. 28(4)
Big Blue Rat-2 cells were evaluated for mutagenesis and mutational spectra (spontaneous and ethylnitrosourea [ENU]-induced). Survival, mutant frequency, population doubling time, and kinetics of mutant increase (to 120 hr) were determined. Exposures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7e3e09e4de4fd08e4e76a98a1c4c80de
https://pubmed.ncbi.nlm.nih.gov/8991060
https://pubmed.ncbi.nlm.nih.gov/8991060
Publikováno v:
Environmental and molecular mutagenesis. 20(2)
The study of hprt mutations in cynomolgus monkey T-lymphocytes is part of our effort to understand the mechanisms of mutagenesis in vivo. This primate model allows us to study mutations and their kinetics at the molecular level under well-controlled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a9ee0b4eddf2ee1e4ddf4b0bfb52d8
https://pubmed.ncbi.nlm.nih.gov/1505533
https://pubmed.ncbi.nlm.nih.gov/1505533
Publikováno v:
Cancer research. 48(1)
CC-1065 is a very potent antitumor antibiotic which binds in the minor groove of DNA with alkylation at N-3 of adenine. Since CC-1065 caused delayed deaths in mice at therapeutic doses, analogues were prepared whose antitumor and biochemical activiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::730604a34daf88e92a210edfd66e7730
https://pubmed.ncbi.nlm.nih.gov/3334998
https://pubmed.ncbi.nlm.nih.gov/3334998