Zobrazeno 1 - 10
of 29
pro vyhledávání: '"P R, Gooley"'
Autor:
Kazem Asadollahi, Sunnia Rajput, Lazarus Andrew de Zhang, Ching-Seng Ang, Shuai Nie, Nicholas A. Williamson, Michael D. W. Griffin, Ross A. D. Bathgate, Daniel J. Scott, Thomas R. Weikl, Guy N. L. Jameson, Paul R. Gooley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The conformational ensembles of G protein-coupled receptors (GPCRs) include inactive and active states. Spectroscopy techniques, including NMR, show that agonists, antagonists and other ligands shift the ensemble toward specific states depen
Externí odkaz:
https://doaj.org/article/8a32b17098464f42af0a3f2a34e66fbb
Autor:
Riley D. Metcalfe, Eric Hanssen, Ka Yee Fung, Kaheina Aizel, Clara C. Kosasih, Courtney O. Zlatic, Larissa Doughty, Craig J. Morton, Andrew P. Leis, Michael W. Parker, Paul R. Gooley, Tracy L. Putoczki, Michael D. W. Griffin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Interleukin (IL-)11, an IL-6 family cytokine, has pivotal roles in autoimmune diseases, fibrotic complications, and solid cancers. Despite intense therapeutic targeting efforts, structural understanding of IL-11 signalling and mechanistic in
Externí odkaz:
https://doaj.org/article/57a7cb56921f49669d1a14d82f0a823a
Autor:
Seyed Mohammad Ghafoori, Ashish Sethi, Gayle F. Petersen, Mohammad Hossein Tanipour, Paul R. Gooley, Jade K. Forwood
Publikováno v:
Cells, Vol 13, Iss 14, p 1202 (2024)
SOX proteins are a family of transcription factors (TFs) that play critical functions in sex determination, neurogenesis, and chondrocyte differentiation, as well as cardiac, vascular, and lymphatic development. There are 20 SOX family members in hum
Externí odkaz:
https://doaj.org/article/c1a1ba8566ae474ca098ef2907183cd9
Autor:
Fabian Bumbak, James B. Bower, Skylar C. Zemmer, Asuka Inoue, Miquel Pons, Juan Carlos Paniagua, Fei Yan, James Ford, Hongwei Wu, Scott A. Robson, Ross A. D. Bathgate, Daniel J. Scott, Paul R. Gooley, Joshua J. Ziarek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The neurotensin receptor 1 (NTS1) is a G protein-coupled receptor (GPCR) with promise as a drug target for the treatment of pain, schizophrenia, obesity, addiction, and various cancers. A detailed picture of the NTS1 structural landscape has
Externí odkaz:
https://doaj.org/article/acdea264c4e64456b3085202211dd251
Autor:
Christopher W. Armstrong, Fane F. K. Mensah, Maria J. Leandro, Venkat Reddy, Paul R. Gooley, Saul Berkovitz, Geraldine Cambridge
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionDisturbances of energy metabolism contribute to the clinical manifestations of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Previously, we found that B cells from ME/CFS patients have an increased expression of CD24, a mod
Externí odkaz:
https://doaj.org/article/16803fdcd8cc4367b8b7695459a54a96
Autor:
Fabian Bumbak, Miquel Pons, Asuka Inoue, Juan Carlos Paniagua, Fei Yan, Hongwei Wu, Scott A. Robson, Ross A.D. Bathgate, Daniel J. Scott, Paul R. Gooley, Joshua J. Ziarek
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 112015- (2023)
Summary: Nuclear magnetic resonance (NMR) studies have revealed that fast methyl sidechain dynamics can report on entropically-driven allostery. Yet, NMR applications have been largely limited to the super-microsecond motional regimes of G protein-co
Externí odkaz:
https://doaj.org/article/e832682210c9421aa7945f05bde3d419
Publikováno v:
Metabolites, Vol 12, Iss 10, p 963 (2022)
Nuclear magnetic resonance (NMR) spectroscopy is one of the principal analytical techniques for metabolomics. It has the advantages of minimal sample preparation and high reproducibility, making it an ideal technique for generating large amounts of m
Externí odkaz:
https://doaj.org/article/761d0d5c3f9a4ed6a8d6dbbc27540ac0
Autor:
Jingyu Zhan, Angela R Harrison, Stephanie Portelli, Thanh Binh Nguyen, Isshu Kojima, Siqiong Zheng, Fei Yan, Tatsunori Masatani, Stephen M Rawlinson, Ashish Sethi, Naoto Ito, David B Ascher, Gregory W Moseley, Paul R Gooley
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009729 (2021)
Rabies virus phosphoprotein (P protein) is a multifunctional protein that plays key roles in replication as the polymerase cofactor that binds to the complex of viral genomic RNA and the nucleoprotein (N protein), and in evading the innate immune res
Externí odkaz:
https://doaj.org/article/04e7c1bd948047038f0c27a6d86a6c67
Autor:
Bradley L. Hoare, Shoni Bruell, Ashish Sethi, Paul R. Gooley, Michael J. Lew, Mohammed A. Hossain, Asuka Inoue, Daniel J. Scott, Ross A.D. Bathgate
Publikováno v:
iScience, Vol 11, Iss , Pp 93-113 (2019)
Summary: The peptide hormone H2 relaxin has demonstrated promise as a therapeutic, but mimetic development has been hindered by the poorly understood relaxin receptor RXFP1 activation mechanism. H2 relaxin is hypothesized to bind to two distinct ECD
Externí odkaz:
https://doaj.org/article/106ae93fb3814699bbd1551cc5a6f606
Autor:
Carra A Simpson, Orli S Schwartz, Djamila Eliby, Catherine A Butler, Katherine Huang, Neil O'Brien-Simpson, Bridget L Callaghan, Stuart G Dashper, Paul R Gooley, Sarah Whittle, Nick Haslam, Julian G Simmons
Publikováno v:
BMJ Open, Vol 11, Iss 3 (2021)
Introduction Research has highlighted relationships between the micro-organisms that inhabit our gastrointestinal tract (oral and gut microbiota) with host mood and gastrointestinal functioning. Mental health disorders and functional gastrointestinal
Externí odkaz:
https://doaj.org/article/84e398a4ea0c434caba52bfc0c448188