Zobrazeno 1 - 10
of 17
pro vyhledávání: '"P R, Garvin"'
Autor:
Kyle A. Sullivan, Matthew Lane, Mikaela Cashman, J. Izaak Miller, Mirko Pavicic, Angelica M. Walker, Ashley Cliff, Jonathon Romero, Xuejun Qin, Niamh Mullins, Anna Docherty, Hilary Coon, Douglas M. Ruderfer, International Suicide Genetics Consortium, VA Million Veteran Program, MVP Suicide Exemplar Workgroup, Michael R. Garvin, John P. Pestian, Allison E. Ashley-Koch, Jean C. Beckham, Benjamin McMahon, David W. Oslin, Nathan A. Kimbrel, Daniel A. Jacobson, David Kainer
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Genome-wide association studies (GWAS) identify genetic variants underlying complex traits but are limited by stringent genome-wide significance thresholds. We present GRIN (Gene set Refinement through Interacting Networks), which increases
Externí odkaz:
https://doaj.org/article/f343f4bdee8040aa88cb30c2c4276f5a
Autor:
Hongran Li, Xinyue Liang, Yan Peng, Zhenxing Liu, Lei Zhang, Ping Wang, Minghui Jin, Kenneth Wilson, Michael R. Garvin, Kongming Wu, Yutao Xiao
Publikováno v:
Advanced Science, Vol 11, Iss 34, Pp n/a-n/a (2024)
Abstract A fundamental understanding of the underlying mechanisms involved in biological invasions is crucial to developing effective risk assessment and control measures against invasive species. The fall armyworm (FAW), Spodoptera frugiperda, is a
Externí odkaz:
https://doaj.org/article/3fc98f5f6be343068306b11fea2730f2
Autor:
Mirko Pavicic, Angelica M. Walker, Kyle A. Sullivan, John Lagergren, Ashley Cliff, Jonathon Romero, Jared Streich, Michael R. Garvin, John Pestian, Benjamin McMahon, David W. Oslin, Jean C. Beckham, Nathan A. Kimbrel, Daniel A. Jacobson
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
IntroductionDespite a recent global decrease in suicide rates, death by suicide has increased in the United States. It is therefore imperative to identify the risk factors associated with suicide attempts to combat this growing epidemic. In this stud
Externí odkaz:
https://doaj.org/article/c1610b9782bd436caedb89b98091ebb4
Autor:
Mikhail A. Hameedi, Erica T. Prates, Michael R. Garvin, Irimpan I. Mathews, B. Kirtley Amos, Omar Demerdash, Mark Bechthold, Mamta Iyer, Simin Rahighi, Daniel W. Kneller, Andrey Kovalevsky, Stephan Irle, Van-Quan Vuong, Julie C. Mitchell, Audrey Labbe, Stephanie Galanie, Soichi Wakatsuki, Daniel Jacobson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors report crystallographic and computational studies that detail how SARS-CoV-2 3CLpro cleaves the host NF-κB Essential Modulator in addition to its canonical viral substrates. The association with the high fitness of SARS-CoV-2 in humans i
Externí odkaz:
https://doaj.org/article/f4a60ed5420947fea700b6dd36aeb82f
Autor:
Dmytro V. Gospodaryov, J. William O. Ballard, M. Florencia Camus, Rob DeSalle, Michael R. Garvin, Uwe Richter
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/5e881a34f7234a459f5f8ec1d860bee7
Autor:
David Kainer, Alan R. Templeton, Erica T. Prates, Daniel Jacboson, Euan R.O. Allan, Sharlee Climer, Michael R. Garvin
Publikováno v:
HGG Advances, Vol 4, Iss 1, Pp 100150- (2023)
Summary: The heritability of autism spectrum disorder (ASD), based on 680,000 families and five countries, is estimated to be nearly 80%, yet heritability reported from SNP-based studies are consistently lower, and few significant loci have been iden
Externí odkaz:
https://doaj.org/article/a0dba97601ab44de9f8716863efa1c52
Autor:
Michael R. Garvin, Erica T. Prates, Mirko Pavicic, Piet Jones, B. Kirtley Amos, Armin Geiger, Manesh B. Shah, Jared Streich, Joao Gabriel Felipe Machado Gazolla, David Kainer, Ashley Cliff, Jonathon Romero, Nathan Keith, James B. Brown, Daniel Jacobson
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-26 (2020)
Abstract Background A mechanistic understanding of the spread of SARS-CoV-2 and diligent tracking of ongoing mutagenesis are of key importance to plan robust strategies for confining its transmission. Large numbers of available sequences and their da
Externí odkaz:
https://doaj.org/article/4f460bb5837c4132ab6f500c3b3dc747
Autor:
Alan E Mast, Alisa S Wolberg, David Gailani, Michael R Garvin, Christiane Alvarez, J Izaak Miller, Piet Jones, Bruce Aronow, Daniel Jacobson
Publikováno v:
eLife, Vol 11 (2022)
Early in the SARS-CoV-2 pandemic, we compared transcriptome data from hospitalized COVID-19 patients and control patients without COVID-19. We found changes in procoagulant and fibrinolytic gene expression in the lungs of COVID-19 patients (Mast et a
Externí odkaz:
https://doaj.org/article/6f80d1bcca304f5ab500cec044ad3eb3
Autor:
Alan E Mast, Alisa S Wolberg, David Gailani, Michael R Garvin, Christiane Alvarez, J Izaak Miller, Bruce Aronow, Daniel Jacobson
Publikováno v:
eLife, Vol 10 (2021)
Extensive fibrin deposition in the lungs and altered levels of circulating blood coagulation proteins in COVID-19 patients imply local derangement of pathways that limit fibrin formation and/or promote its clearance. We examined transcriptional profi
Externí odkaz:
https://doaj.org/article/c9cf14268af2449ebec4df152af85aff
Autor:
Michael R Garvin, Christiane Alvarez, J Izaak Miller, Erica T Prates, Angelica M Walker, B Kirtley Amos, Alan E Mast, Amy Justice, Bruce Aronow, Daniel Jacobson
Publikováno v:
eLife, Vol 9 (2020)
Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we present a novel molecular mechanism for COVID-19 that provides therapeutic intervention points that can be addressed with existing FDA-approved pharmaceuticals. T
Externí odkaz:
https://doaj.org/article/7ca8502352754188ae4bff950a8b4f2e