Zobrazeno 1 - 10
of 49
pro vyhledávání: '"P R, Cullis"'
Autor:
Francesca Ferraresso, Katherine Badior, Monica Seadler, Youjie Zhang, Amanda Wietrzny, Massimo F. Cau, Amber Haugen, Geoffrey G. Rodriguez, Mitchell R. Dyer, Pieter R. Cullis, Eric Jan, Christian J. Kastrup
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101314- (2024)
In vivo delivery of mRNA is promising for the study of gene expression and the treatment of diseases. Lipid nanoparticles (LNPs) enable efficient delivery of mRNA constructs, but protein expression has been assumed to be limited to the liver. With sp
Externí odkaz:
https://doaj.org/article/0a01dff2207d42cfb668095ac39d3282
Autor:
Massimo F. Cau, Francesca Ferraresso, Monica Seadler, Katherine Badior, Youjie Zhang, Laura M. Ketelboeter, Geoffrey G. Rodriguez, Taylor Chen, Matteo Ferraresso, Amanda Wietrzny, Madelaine Robertson, Amber Haugen, Pieter R. Cullis, Marc de Moya, Mitchell Dyer, Christian J. Kastrup
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101258- (2024)
Genetic manipulation of animal models is a fundamental research tool in biology and medicine but is challenging in large animals. In rodents, models can be readily developed by knocking out genes in embryonic stem cells or by knocking down genes thro
Externí odkaz:
https://doaj.org/article/81d09d224d2d4279aaec348f3d6c4563
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 235-245 (2023)
Lipid nanoparticles (LNPs) for delivery of mRNA usually contain ionizable lipid/helper lipid/cholesterol/PEG-lipid in molar ratios of 50:10:38.5:1.5, respectively. These LNPs are rapidly cleared from the circulation following intravenous (i.v.) admin
Externí odkaz:
https://doaj.org/article/cc0ad7f89d644d7c82b5f5591ee35a42
Autor:
Muhammad A. Asif, Sean L. Bithell, Ramethaa Pirathiban, Brian R. Cullis, David Glyn Dionaldo Hughes, Aidan McGarty, Nicole Dron, Kristy Hobson
Publikováno v:
Plants, Vol 12, Iss 23, p 4069 (2023)
Phytophthora root rot (PRR) is a major constraint to chickpea production in Australia. Management options for controlling the disease are limited to crop rotation and avoiding high risk paddocks for planting. Current Australian cultivars have partial
Externí odkaz:
https://doaj.org/article/73121a87cdc84a969ca38aada31ecfd9
Publikováno v:
Frontiers in Plant Science, Vol 12 (2021)
Low temperatures during the flowering period of cereals can lead to floret sterility, yield reduction, and economic losses in Australian crops. In order to breed for improved frost susceptibility, selection methods are urgently required to identify n
Externí odkaz:
https://doaj.org/article/378abf3aea984831adb248e153684cc0
Publikováno v:
Frontiers in Marine Science, Vol 7 (2020)
Fishing strategies, effort and harvests of small-scale fishers are important to understand for effective planning of regulatory measures and development programs. Gender differences in fishing can highlight inequities deserving transformative solutio
Externí odkaz:
https://doaj.org/article/dce32fee245648039fcd066bebccffa2
Autor:
Emi Tanaka, Jean-Phillippe F. Ral, Sean Li, Raj Gaire, Colin R. Cavanagh, Brian R. Cullis, Alex Whan
Publikováno v:
Plant Methods, Vol 13, Iss 1, Pp 1-7 (2017)
Abstract Background The proportion of granule types in wheat starch is an important characteristic that can affect its functionality. It is widely accepted that granule types are either large, disc-shaped A-type granules or small, spherical B-type gr
Externí odkaz:
https://doaj.org/article/b96f2758a0e94f468f86da6b0d85f520
Autor:
Ursula H. Neumann, Jessica S.S. Ho, Sam Chen, Yuen Yi C. Tam, Pieter R. Cullis, Timothy J. Kieffer
Publikováno v:
Molecular Metabolism, Vol 6, Iss 10, Pp 1161-1172 (2017)
Objective: Hyperglucagonemia is present in many forms of diabetes and contributes to hyperglycemia, and glucagon suppression can ameliorate diabetes in mice. Leptin, a glucagon suppressor, can also reverse diabetes in rodents. Lipid nanoparticle (LNP
Externí odkaz:
https://doaj.org/article/532b74c5d2db4fb3b5861d93c654d0c4
Publikováno v:
Ecology and Society, Vol 26, Iss 1, p 14 (2021)
The predicted future shortfall in seafood production from tropical small-scale fisheries demands support to help diversify income streams and food production for coastal communities. Livelihood diversification can comprise the enhancement or addition
Externí odkaz:
https://doaj.org/article/9954d21809ac41cdb6c295118333b6ed
Publikováno v:
Global Ecology and Conservation, Vol 3, Iss C, Pp 878-889 (2015)
This study investigates mortality of sharks in a commercial longline fishery in Australia. To examine the rate and biological, environmental and technological factors contributing to at-vessel mortality, four setlines with 120 gangions possessing ‘
Externí odkaz:
https://doaj.org/article/6129da26c80e443a9a91679c68d31ce5