Výsledky vyhledávání - "P R, Bunnell"

An investigation of the relationship between caloric intake and outcome in hospitalized dogs

Autor: R L, Remillard, D E, Darden, K E, Michel, S L, Marks, C A, Buffington, P R, Bunnell

Publikováno v: Veterinary therapeutics : research in applied veterinary medicine. 2(4)

Malnutrition in veterinary patients is thought to increase morbidity and mortality, but this has not been statistically quantified. A study was designed to estimate the proportion of hospitalized canine patients in negative-energy balance; relate cal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3234b7cf3a5dc64aa3045c8bac600de
https://pubmed.ncbi.nlm.nih.gov/19746652

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[(Aminomethy)aryloxy]acetic Acid Esters. A New Class of High-Ceiling Diuretics. 4. Substituted 6,7-Dichloro-2,3-dihydrobenzofurans Derived by Ring Annelation

Autor: Jacob J. Plattner, Cheuk-Man Lee, P. R. Bunnell, Michael J. Field, Gerhard Giebisch, James A. Parks

Publikováno v: Journal of Medicinal Chemistry. 28:589-594

Ring annelation of the [(aminomethyl)aryloxy]acetic acids produced a series of substituted 6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acids. Pharmacologic evaluation of these compounds in rats and dogs indicated that several congeners are extrem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25e6a6d426d4d77666860883e4ca4d9
https://doi.org/10.1021/jm50001a009

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Substituted 5,6-dihydrofuro[3,2-f]-1,2-benzisoxazole-6-carboxylic acids: high-ceiling diuretics with uricosuric activity

Autor: Steven R. Crowley, Andre G. Pernet, P. R. Bunnell, Richard J. Pariza, James A. Parks, P. W. Dodge, Anthony K. L. Fung, Jacob J. Plattner

Publikováno v: Journal of medicinal chemistry. 27(8)

A series of substituted 5,6-dihydrofuro[3,2-f]-1,2-benzisoxazoles was prepared and evaluated for their saluretic and uricosuric properties. Pharmacological evaluation of the title compounds was carried out in mice, rats, dogs, and monkeys. The diuret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1f87f599e267d87c0a7b5f104ac88f
https://pubmed.ncbi.nlm.nih.gov/6431103

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[(Aminomethyl)aryloxy]acetic acid esters. A new class of high-ceiling diuretics. 2. Modifications of the oxyacetic side chain

Autor: Steven R. Crowley, Lawrence T. Sennello, Jill R. Smital, Cheuk Man Lee, P. R. Bunnell, Jacob J. Plattner, Steven A. Buckner, Anthony K. L. Fung, Andre G. Pernet

Publikováno v: Journal of medicinal chemistry. 27(12)

The discovery of high-ceiling natriuretic activity from a series of aminomethyl derivatives of ethyl [2,3-dichloro-4-(4-hydroxybenzoyl)phenoxy]acetate prompted our continued investigation of this new class of (aryloxy)acetic acid diuretics. Systemati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a60557a600974e27a1ec484d659088d
https://pubmed.ncbi.nlm.nih.gov/6502592

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ChemInform Abstract: ((AMINOMETHYL)ARYLOXY)ACETIC ACID ESTERS. A NEW CLASS OF HIGH-CEILING DIURETICS. 3. VARIATION IN THE BRIDGE BETWEEN THE AROMATIC RINGS TO COMPLETE MAPPING OF THE RECEPTOR

Autor: Jacob J. Plattner, Andre G. Pernet, Ki H. Kim, Yvonne C. Martin, Lee Cheuk M, Jill R. Smital, P. R. Bunnell, Steven R. Crowley, Anthony K. L. Fung, Bruce W. Horrom

Publikováno v: Chemischer Informationsdienst. 16

Continued structural evaluation of the [(aminomethyl)aryloxy]acetic ester diuretics has produced a series of compounds in which the functional group that bridges the two aromatic rings has been varied. Diuretic screening of these analogues in rats in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8afe273b1cebc8db36e01b24d44f980
https://doi.org/10.1002/chin.198521144

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[(Aminomethyl)arloxy]acetic acid esters. A new class of high-ceiling diuretics. 3. Variation in the bridge between the aromatic rings to complete mapping of the receptor

Autor: P. R. Bunnell, Jacob J. Plattner, Ki H. Kim, Bruce W. Horrom, Lee Cheuk M, Anthony K. L. Fung, Andre G. Pernet, Yvonne C. Martin, Jill R. Smital, Steven R. Crowley

Publikováno v: Journal of medicinal chemistry. 28(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd83f1fc28eae66590a3f58336ca2833
https://pubmed.ncbi.nlm.nih.gov/3965716

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