Zobrazeno 1 - 10
of 26
pro vyhledávání: '"P Patrizia Mangione"'
Autor:
Tamer Rezk, Janet A Gilbertson, P Patrizia Mangione, Dorota Rowczenio, Nigel B Rendell, Diana Canetti, Helen J Lachmann, Ashutosh D Wechalekar, Paul Bass, Philip N Hawkins, Vittorio Bellotti, Graham W Taylor, Julian D Gillmore
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 5, Iss 3, Pp 145-153 (2019)
Abstract The tissue diagnosis of amyloidosis and confirmation of fibril protein type, which are crucial for clinical management, have traditionally relied on Congo red (CR) staining followed by immunohistochemistry (IHC) using fibril protein specific
Externí odkaz:
https://doaj.org/article/9387814b13b64cdd87bd2fdab0cb78d9
Autor:
Julien Marcoux, P Patrizia Mangione, Riccardo Porcari, Matteo T Degiacomi, Guglielmo Verona, Graham W Taylor, Sofia Giorgetti, Sara Raimondi, Sarah Sanglier‐Cianférani, Justin LP Benesch, Ciro Cecconi, Mohsin M Naqvi, Julian D Gillmore, Philip N Hawkins, Monica Stoppini, Carol V Robinson, Mark B Pepys, Vittorio Bellotti
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 10, Pp 1337-1349 (2015)
Abstract The mechanisms underlying transthyretin‐related amyloidosis in vivo remain unclear. The abundance of the 49–127 transthyretin fragment in ex vivo deposits suggests that a proteolytic cleavage has a crucial role in destabilizing the tetra
Externí odkaz:
https://doaj.org/article/73bd04162dae41c1a8592516fd43e2e6
Autor:
Sara Raimondi, Giulia Faravelli, Paola Nocerino, Valentina Mondani, Alma Baruffaldi, Loredana Marchese, Maria Chiara Mimmi, Diana Canetti, Guglielmo Verona, Marianna Caterino, Margherita Ruoppolo, P. Patrizia Mangione, Vittorio Bellotti, Francesca Lavatelli, Sofia Giorgetti
Publikováno v:
FASEB BioAdvances, Vol 5, Iss 11, Pp 484-505 (2023)
Abstract β2‐microglobulin (β2‐m) is a plasma protein derived from physiological shedding of the class I major histocompatibility complex (MHCI), causing human systemic amyloidosis either due to persistently high concentrations of the wild‐typ
Externí odkaz:
https://doaj.org/article/5149cb901be64b8ea5200c5f776cb102
Autor:
Ivana Slamova, Rozita Adib, Stephan Ellmerich, Michal R. Golos, Janet A. Gilbertson, Nicola Botcher, Diana Canetti, Graham W. Taylor, Nigel Rendell, Glenys A. Tennent, Guglielmo Verona, Riccardo Porcari, P. Patrizia Mangione, Julian D. Gillmore, Mark B. Pepys, Vittorio Bellotti, Philip N. Hawkins, Raya Al-Shawi, J. Paul Simons
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
ATTR amyloidosis causes heart failure through the accumulation of misfolded transthyretin in cardiac muscle. Here the authors report a mouse model of ATTR amyloidosis and demonstrate the involvement of protease activity in ATTR amyloid deposition.
Externí odkaz:
https://doaj.org/article/52dd9743e5e94eff8fed79314e07bdac
Autor:
Giulia Faravelli, Valentina Mondani, P. Patrizia Mangione, Sara Raimondi, Loredana Marchese, Francesca Lavatelli, Monica Stoppini, Alessandra Corazza, Diana Canetti, Guglielmo Verona, Laura Obici, Graham W. Taylor, Julian D. Gillmore, Sofia Giorgetti, Vittorio Bellotti
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The globular to fibrillar transition of proteins represents a key pathogenic event in the development of amyloid diseases. Although systemic amyloidoses share the common characteristic of amyloid deposition in the extracellular matrix, they are clini
Externí odkaz:
https://doaj.org/article/78918c93ba684ff5a907851006159caf
Autor:
Graham W. Taylor, Janet A. Gilbertson, Rabya Sayed, Angel Blanco, Nigel B. Rendell, Dorota Rowczenio, Tamer Rezk, P. Patrizia Mangione, Diana Canetti, Paul Bass, Philip N. Hawkins, Julian D. Gillmore
Publikováno v:
Kidney International Reports, Vol 4, Iss 7, Pp 977-986 (2019)
Introduction: Hereditary fibrinogen Aα-chain (AFib) amyloidosis is a relatively uncommon renal disease associated with a small number of pathogenic fibrinogen Aα (FibA) variants; wild-type FibA normally does not result in amyloid deposition. Proteo
Externí odkaz:
https://doaj.org/article/034578518fe347d4a2ac583d09552583
Autor:
Guglielmo Verona, P. Patrizia Mangione, Sara Raimondi, Sofia Giorgetti, Giulia Faravelli, Riccardo Porcari, Alessandra Corazza, Julian D. Gillmore, Philip N. Hawkins, Mark B. Pepys, Graham W. Taylor, Vittorio Bellotti
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract Dissociation of the native transthyretin (TTR) tetramer is widely accepted as the critical step in TTR amyloid fibrillogenesis. It is modelled by exposure of the protein to non-physiological low pH in vitro and is inhibited by small molecule
Externí odkaz:
https://doaj.org/article/f338b2bcadbe45189416b0237ad95585
Autor:
Sophie Valleix, Guglielmo Verona, Noémie Jourde-Chiche, Brigitte Nédelec, P. Patrizia Mangione, Frank Bridoux, Alain Mangé, Ahmet Dogan, Jean-Michel Goujon, Marie Lhomme, Carolane Dauteuille, Michèle Chabert, Riccardo Porcari, Christopher A. Waudby, Annalisa Relini, Philippa J. Talmud, Oleg Kovrov, Gunilla Olivecrona, Monica Stoppini, John Christodoulou, Philip N. Hawkins, Gilles Grateau, Marc Delpech, Anatol Kontush, Julian D. Gillmore, Athina D. Kalopissis, Vittorio Bellotti
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Decrease in Apolipoprotein C-III (ApoC-III) yields a cardioprotective lipoprotein profile. Here, Valleix et al.reveal a novel ApoC-III variant conferring low plasma ApoC-III concentration and cardioprotection despite renal insufficiency, and, unexpec
Externí odkaz:
https://doaj.org/article/20852c4360d64aac8c27c28e258ec648
Autor:
Cristina Cantarutti, Maria Chiara Mimmi, Guglielmo Verona, Walter Mandaliti, Graham W. Taylor, P. Patrizia Mangione, Sofia Giorgetti, Vittorio Bellotti, Alessandra Corazza
Publikováno v:
Biomolecules; Volume 12; Issue 8; Pages: 1066
The plasma protein transthyretin (TTR), a transporter for thyroid hormones and retinol in plasma and cerebrospinal fluid, is responsible for the second most common type of systemic (ATTR) amyloidosis either in its wild type form or as a result of des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c2b62e416b2228cc7ee99e60371ddf
http://hdl.handle.net/11390/1232124
http://hdl.handle.net/11390/1232124
Autor:
Giulia, Faravelli, Valentina, Mondani, P Patrizia, Mangione, Sara, Raimondi, Loredana, Marchese, Francesca, Lavatelli, Monica, Stoppini, Alessandra, Corazza, Diana, Canetti, Guglielmo, Verona, Laura, Obici, Graham W, Taylor, Julian D, Gillmore, Sofia, Giorgetti, Vittorio, Bellotti
Publikováno v:
Frontiers in molecular biosciences. 9
The globular to fibrillar transition of proteins represents a key pathogenic event in the development of amyloid diseases. Although systemic amyloidoses share the common characteristic of amyloid deposition in the extracellular matrix, they are clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c156592fb1fc0f02d9a8e1e785981cf2
https://pubmed.ncbi.nlm.nih.gov/35237660
https://pubmed.ncbi.nlm.nih.gov/35237660