Výsledky vyhledávání - "P N, Usherwood"

Activation of Drosophila sodium channels promotes modification by deltamethrin. Reductions in affinity caused by knock-down resistance mutations

Autor: H, Vais, M S, Williamson, S J, Goodson, A L, Devonshire, J W, Warmke, P N, Usherwood, C J, Cohen

Publikováno v: The Journal of General Physiology

kdr and super-kdr are mutations in houseflies and other insects that confer 30- and 500-fold resistance to the pyrethroid deltamethrin. They correspond to single (L1014F) and double (L1014F+M918T) mutations in segment IIS6 and linker II(S4–S5) of N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc24895578eb35194f68998f3dfd3a27
https://pubmed.ncbi.nlm.nih.gov/10694259

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Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12

Autor: K, Strømgaard, I, Bjørnsdottir, K, Andersen, M J, Brierley, S, Rizoli, N, Eldursi, I R, Mellor, P N, Usherwood, S H, Hansen, P, Krogsgaard-Larsen, J W, Jaroszewski

Publikováno v: Chirality. 12(2)

PhTX-343 and PhTX-12, analogues of the natural polyamine wasp toxin PhTX-433, were synthesised in 40-60% yields as pure enantiomers using solid phase synthesis techniques. Capillary electrophoresis procedures were developed for chiral separation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ddacf9faab78c6790f242df16996a1de
https://pubmed.ncbi.nlm.nih.gov/10637415

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Structure-activity relationship and site of binding of polyamine derivatives at the nicotinic acetylcholine receptor

Autor: M G, Bixel, M, Krauss, Y, Liu, M L, Bolognesi, M, Rosini, I S, Mellor, P N, Usherwood, C, Melchiorre, K, Nakanishi, F, Hucho

Publikováno v: European journal of biochemistry. 267(1)

Several wasp venoms contain philanthotoxins (PhTXs), natural polyamine amides, which act as noncompetitive inhibitors (NCIs) on the nicotinic acetylcholine receptor (nAChR). Effects of varying the structure of PhTXs and poly(methylene tetramine)s on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8996c4defe0cb0b99c39e1d28535e5df
https://pubmed.ncbi.nlm.nih.gov/10601857

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Selective antagonism of native and cloned kainate and NMDA receptors by polyamine-containing toxins

Autor: P T, Brackley, D R, Bell, S K, Choi, K, Nakanishi, P N, Usherwood

Publikováno v: The Journal of pharmacology and experimental therapeutics. 266(3)

Antagonism of rat excitatory amino acid receptors by a synthetic analog [philanthotoxin-343 (PhTX-343)] of a polyamine amide, wasp toxin (philanthotoxin-433) and a structurally related spider toxin, argiotoxin-636 (ArgTX-636), was examined in Xenopus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e5feab44f13e160c268b8ac2a026b054
https://pubmed.ncbi.nlm.nih.gov/7690404

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Are chimeric kainate/N-methyl-D-aspartate receptors expressed in Xenopus oocytes from mammalian and amphibian RNA?

Autor: P T, Brackley, P N, Usherwood

Publikováno v: The Journal of pharmacology and experimental therapeutics. 265(2)

The Xenopus oocyte expression system has been used to test for the existence in rat and Xenopus central nervous systems (CNS) of excitatory amino acid receptors (EAAR) that show sensitivity to both N-methyl-D-aspartate (NMDA) and L-kainate. Two to 15

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7521cc82c0eda6df3347634c95b9c5e
https://pubmed.ncbi.nlm.nih.gov/7684447

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Transmitter release from normal and degenerating locust motor nerve terminals

Autor: J P Hodgkiss, P N Usherwood

Publikováno v: The Journal of Physiology. 285:113-128

1. An analysis has been made of spontaneous and evoked transmitter release from terminals of 'fast' excitatory motor axons on locust muscle fibres using intra- and extracellular recording together with a Ca-electrode technique for activating transmit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cd9783b6761f2cdebd921c352eb705
https://doi.org/10.1113/jphysiol.1978.sp012561

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Periodical

Potentiation and inhibition of nicotinic acetylcholine receptors by spermine in the TE671 human muscle cell line.

Autor: Z, Shao, R, Mellor I, J, Brierley M, J, Harris, N, Usherwood P

Publikováno v: The Journal of Pharmacology and Experimental Therapeutics; September 1998, Vol. 286 Issue: 3 p1269-76, 8p

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