Zobrazeno 1 - 10
of 27
pro vyhledávání: '"P N, Tonin"'
Autor:
Wejdan M. Alenezi, Caitlin T. Fierheller, Corinne Serruya, Timothée Revil, Kathleen K. Oros, Deepak N. Subramanian, Jeffrey Bruce, Dan Spiegelman, Trevor Pugh, Ian G. Campbell, Anne-Marie Mes-Masson, Diane Provencher, William D. Foulkes, Zaki El Haffaf, Guy Rouleau, Luigi Bouchard, Celia M. T. Greenwood, Jiannis Ragoussis, Patricia N. Tonin
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Not all familial ovarian cancer (OC) cases are explained by pathogenic germline variants in known risk genes. A candidate gene approach involving DNA repair pathway genes was applied to identify rare recurring pathogenic variants in familial OC cases
Externí odkaz:
https://doaj.org/article/05d239ab593d4e42b75d51380a913fb1
Autor:
Caitlin T. Fierheller, Laure Guitton-Sert, Wejdan M. Alenezi, Timothée Revil, Kathleen K. Oros, Yuandi Gao, Karine Bedard, Suzanna L. Arcand, Corinne Serruya, Supriya Behl, Liliane Meunier, Hubert Fleury, Eleanor Fewings, Deepak N. Subramanian, Javad Nadaf, Jeffrey P. Bruce, Rachel Bell, Diane Provencher, William D. Foulkes, Zaki El Haffaf, Anne-Marie Mes-Masson, Jacek Majewski, Trevor J. Pugh, Marc Tischkowitz, Paul A. James, Ian G. Campbell, Celia M. T. Greenwood, Jiannis Ragoussis, Jean-Yves Masson, Patricia N. Tonin
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-26 (2021)
Abstract Background Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination (HR) of DNA, could involve pathogenic variants in other DNA r
Externí odkaz:
https://doaj.org/article/52b67832911d434ca9c1266c56a3622d
Autor:
Thibaut S. Matis, Nadia Zayed, Bouchra Labraki, Manon de Ladurantaye, Théophane A. Matis, José Camacho Valenzuela, Nancy Hamel, Adrienne Atayan, Barbara Rivera, Yuval Tabach, Patricia N. Tonin, Alexandre Orthwein, Anne-Marie Mes-Masson, Zaki El Haffaf, William D. Foulkes, Paz Polak
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-7 (2021)
Abstract It was hypothesized that variants in underexplored homologous recombination repair (HR) genes could explain unsolved multiple-case breast cancer (BC) families. We investigated HR deficiency (HRD)-associated mutational signatures and second h
Externí odkaz:
https://doaj.org/article/cbb6acef8a0543f6b4e46805a7d21ec0
Autor:
Islam E. Elkholi, Massimo Di Iorio, Somayyeh Fahiminiya, Suzanna L. Arcand, HyeRim Han, Clara Nogué, Supriya Behl, Nancy Hamel, Sylvie Giroux, Manon de Ladurantaye, Olga Aleynikova, Walter H. Gotlieb, Jean-François Côté, François Rousseau, Patricia N. Tonin, Diane Provencher, Anne-Marie MesMasson, Mohammad R. Akbari, Barbara Rivera, William D. Foulkes
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The nuclease MRE11A is often included in genetic test panels for hereditary breast and ovarian cancer (HBOC) due to its BRCA1-related molecular function in the DNA repair pathway. However, whether MRE11A is a true predisposition gene for HBO
Externí odkaz:
https://doaj.org/article/64c0a0aadac845d4b26d482428971ff5
Autor:
Cécile Le Page, Kurosh Rahimi, Martin Köbel, Patricia N. Tonin, Liliane Meunier, Lise Portelance, Monique Bernard, Brad H. Nelson, Marcus Q. Bernardini, John M. S. Bartlett, Dimcho Bachvarov, Walter H. Gotlieb, Blake Gilks, Jessica N. McAlpine, Mark W. Nachtigal, Alain Piché, Peter H. Watson, Barbara Vanderhyden, David G. Huntsman, Diane M. Provencher, Anne-Marie Mes-Masson
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-18 (2018)
Abstract Background Ovarian carcinoma is the most lethal gynecological malignancy due to early dissemination and acquired resistance to platinum-based chemotherapy. Reliable markers that are independent and complementary to clinical parameters are ne
Externí odkaz:
https://doaj.org/article/cdedc148b0a5483d9a92db4fb163269d
Autor:
Stavros Glentis, Alexandros C. Dimopoulos, Konstantinos Rouskas, George Ntritsos, Evangelos Evangelou, Steven A. Narod, Anne-Marie Mes-Masson, William D. Foulkes, Barbara Rivera, Patricia N. Tonin, Jiannis Ragoussis, Antigone S. Dimas
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Approximately 10% of breast cancer (BC) cases are hereditary BC (HBC), with HBC most commonly encountered in the context of hereditary breast and ovarian cancer (HBOC) syndrome. Although thousands of loss-of-function (LoF) alleles in over 20 genes ha
Externí odkaz:
https://doaj.org/article/8290e95b467b41bb87a8dfc6d98944ee
Autor:
Marie-Line Puiffe, Cecile Le Page, Abdelali Filali-Mouhim, Magdalena Zietarska, Véronique Ouellet, Patricia N. Tonin, Mario Chevrette, Diane M. Provencher, Anne-Marie Mes-Masson
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 10, Pp 820-829 (2007)
At least one third of all cases of epithelial ovarian cancer are associated with the production of ascites, although its effect on tumor cell microenvironment remains poorly understood. This study addresses the effect of the heterologous acellular fr
Externí odkaz:
https://doaj.org/article/79892fae3b41497f9da468e4db7fe699
Autor:
Katia Y Cáceres-Gorriti, Euridice Carmona, Véronique Barrès, Kurosh Rahimi, Isabelle J Létourneau, Patricia N Tonin, Diane Provencher, Anne-Marie Mes-Masson
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91000 (2014)
PURPOSE:Epithelial ovarian cancer has the highest mortality rate of all gynecological malignancies. We have shown that high RAN expression strongly correlates with high-grade and poor patient survival in epithelial ovarian cancer. However, as RAN is
Externí odkaz:
https://doaj.org/article/e8d3683e6736405e8c371151d02cab02
Autor:
Paulina M Wojnarowicz, Kathleen Klein Oros, Michael C J Quinn, Suzanna L Arcand, Karen Gambaro, Jason Madore, Ashley H Birch, Manon de Ladurantaye, Kurosh Rahimi, Diane M Provencher, Anne-Marie Mes-Masson, Celia M T Greenwood, Patricia N Tonin
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45484 (2012)
High-grade ovarian serous carcinomas (HGSC) are characterized by TP53 mutations and non-random patterns of chromosomal anomalies, where the nature of the TP53 mutation may correlate with clinical outcome. However, the frequency of common somatic geno
Externí odkaz:
https://doaj.org/article/9467faaf430c4f4db00a32587a331be2
Autor:
Ashley H Birch, Suzanna L Arcand, Kathleen K Oros, Kurosh Rahimi, A Kevin Watters, Diane Provencher, Celia M Greenwood, Anne-Marie Mes-Masson, Patricia N Tonin
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28250 (2011)
Ovarian carcinomas exhibit extensive heterogeneity, and their etiology remains unknown. Histological and genetic evidence has led to the proposal that low grade ovarian serous carcinomas (LGOSC) have a different etiology than high grade carcinomas (H
Externí odkaz:
https://doaj.org/article/df6687adbb2f43e285dec01bbf8c89c9