Zobrazeno 1 - 10
of 19
pro vyhledávání: '"P N, Lowe"'
Autor:
Kamel Mansouri, José T. Moreira-Filho, Charles N. Lowe, Nathaniel Charest, Todd Martin, Valery Tkachenko, Richard Judson, Mike Conway, Nicole C. Kleinstreuer, Antony J. Williams
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract The rapid increase of publicly available chemical structures and associated experimental data presents a valuable opportunity to build robust QSAR models for applications in different fields. However, the common concern is the quality of bot
Externí odkaz:
https://doaj.org/article/ca62db38853a477f8e316d435cd15cb9
Publikováno v:
Drugs in Context, Vol 11, Pp 1-12 (2022)
Hypoglycaemia is a complication associated with the management of both type 1 and type 2 diabetes. Despite newer technologies to help minimize the risk of hypoglycaemia, it remains a barrier for some patients to achieve optimal glycaemic control. In
Externí odkaz:
https://doaj.org/article/a541c3973a65483a8992db213db6cfa7
Autor:
Antony J. Williams, Linda G. T. Gaines, Christopher M. Grulke, Charles N. Lowe, Gabriel F. B. Sinclair, Vicente Samano, Inthirany Thillainadarajah, Bryan Meyer, Grace Patlewicz, Ann M. Richard
Publikováno v:
Frontiers in Environmental Science, Vol 10 (2022)
Per- and polyfluoroalkyl substances (PFAS) are a class of man-made chemicals of global concern for many health and regulatory agencies due to their widespread use and persistence in the environment (in soil, air, and water), bioaccumulation, and toxi
Externí odkaz:
https://doaj.org/article/0f8233458e964425b30820cff28ce2d4
Publikováno v:
Pesquisa Agropecuária Brasileira, Vol 44, Iss 8, Pp 964-968 (2009)
The objective of this work was to evaluate interactions of Lumbricus terrestris juveniles with adults and with inherited burrow systems. An experiment was set up using a two dimensional Evans' boxes microcosm. Adult L. terrestris were added to 16 box
Externí odkaz:
https://doaj.org/article/2d788b960554491c80fff522ca5245f4
Publikováno v:
Journal of Biological Chemistry. 268:10914-10919
Ras GTPase activating proteins (GAPs) contain an invariant motif, -FLR-, within the most conserved region of their catalytic domains. Certain mutations in this motif have greatly reduced activity (Skinner, R. H., Bradley, S., Brown, A. L., Johnson, N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a0a92fbed272a0a08448d9a595198c3
https://doi.org/10.1016/s0021-9258(18)82072-5
https://doi.org/10.1016/s0021-9258(18)82072-5
Publikováno v:
Nature structural biology. 7(5)
The Rho family GTPases, Cdc42, Rac and Rho, regulate signal transduction pathways via interactions with downstream effector proteins. We report here the solution structure of Cdc42 bound to the GTPase binding domain of alphaPAK, an effector of both C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::509985df053692e7ed8ef3ef3a64a781
https://pubmed.ncbi.nlm.nih.gov/10802735
https://pubmed.ncbi.nlm.nih.gov/10802735
Autor:
W K, Alderton, P N, Lowe
Publikováno v:
Methods in enzymology. 301
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2954527a8e1bbda0dcbddeb95780acf9
https://pubmed.ncbi.nlm.nih.gov/9919559
https://pubmed.ncbi.nlm.nih.gov/9919559
Publikováno v:
Biochemistry. 37(21)
p21-activated kinases (PAKs) serve as effector proteins for the GTP-binding proteins Cdc42 and Rac. They are serine/threonine kinases containing the Cdc42/Rac interactive binding (CRIB) motif. The main aim of this study was to define the minimal doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d7c0e75fa40fb98538023df6552f7fa
https://pubmed.ncbi.nlm.nih.gov/9601050
https://pubmed.ncbi.nlm.nih.gov/9601050
Autor:
P J, Mitchell, K T, Barker, J E, Martindale, T, Kamalati, P N, Lowe, M J, Page, B A, Gusterson, M R, Crompton
Publikováno v:
Oncogene. 9(8)
Using a polymerase chain reaction based differential screening approach, we have isolated and characterised a cDNA from a human metastatic breast tumour representing a novel protein tyrosine kinase (brk). Sequencing of brk cDNAs isolated from T-47D a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce1d4129280d1ff8bda5d037614526a7
https://pubmed.ncbi.nlm.nih.gov/8036022
https://pubmed.ncbi.nlm.nih.gov/8036022
Publikováno v:
The Journal of biological chemistry. 268(36)
Single turnover and equilibrium binding measurements on the interaction of Gly-12 and Pro-12 Ras.GTP with the catalytic domains of the GTPase-activating proteins, p120-GAP and neurofibromin, have been made utilizing fluorescent 2'(3')O-(N-methylanthr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::24dcb005f5d0eb3c44a546ad264a8dd5
https://pubmed.ncbi.nlm.nih.gov/8262937
https://pubmed.ncbi.nlm.nih.gov/8262937