Zobrazeno 1 - 10
of 63
pro vyhledávání: '"P N, Durrington"'
Autor:
Bilal Bashir, Jonathan Schofield, Paul Downie, Michael France, Darren M. Ashcroft, Alison K. Wright, Stefano Romeo, Ioanna Gouni-Berthold, Akhlaq Maan, Paul N. Durrington, Handrean Soran
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
AimsHistorically, atherosclerotic cardiovascular disease (ASCVD) risk profile mitigation has had a predominant focus on low density lipoprotein cholesterol (LDL-C). In this narrative review we explore the residual ASCVD risk profile beyond LDL-C with
Externí odkaz:
https://doaj.org/article/c848dfd6eaa84944b4170ee1460c2040
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Paraoxonase 1 (PON1), residing almost exclusively on HDL, was discovered because of its hydrolytic activity towards organophosphates. Subsequently, it was also found to hydrolyse a wide range of substrates, including lactones and lipid hydroperoxides
Externí odkaz:
https://doaj.org/article/058d01f03f154ac588663b722df7f446
Autor:
Shazli Azmi, Maryam Ferdousi, Yifen Liu, Safwaan Adam, Tarza Siahmansur, Georgios Ponirakis, Andrew Marshall, Ioannis N. Petropoulos, Jan Hoong Ho, Akheel A. Syed, John M. Gibson, Basil J. Ammori, Paul N. Durrington, Rayaz A. Malik, Handrean Soran
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Obesity and associated dyslipidemia may contribute to increased cardiovascular disease. Obesity has also been associated with neuropathy. We have investigated presence of peripheral nerve damage in patients with severe obesity without type 2
Externí odkaz:
https://doaj.org/article/ce6f7d4ff81f434ea4ea3b62b86da46e
Autor:
Bilal Bashir, Jan H. Ho, Paul Downie, Paul Hamilton, Gordon Ferns, Dev Datta, Jaimini Cegla, Anthony S. Wierzbicki, Charlotte Dawson, Fiona Jenkinson, Hannah Delaney, Michael Mansfield, Yee Teoh, Zosia Miedzybrodzka, Haya Haso, Paul N. Durrington, Handrean Soran
Publikováno v:
Metabolites, Vol 13, Iss 5, p 621 (2023)
We have reviewed the genetic basis of chylomicronaemia, the difference between monogenic and polygenic hypertriglyceridaemia, its effects on pancreatic, cardiovascular, and microvascular complications, and current and potential future pharmacotherapi
Externí odkaz:
https://doaj.org/article/8b8ae509426f4952adae62cc8f4ad96a
Autor:
Jeetesh V. Patel, Paul J. Flinders, Avni Vyas, Imogen Glover, Avithra J. Rajan, Dorairaj Prabhakaran, Deepak Bhatnagar, K. Srinath Reddy, Michael I. Mackness, J. Kennedy Cruickshank, Elizabeth A. Hughes, Paul N. Durrington
Publikováno v:
European Medical Journal Cardiology, Vol 3, Iss 1, Pp 58-66 (2015)
Background: The global burden of coronary heart disease (CHD) is estimated to be the highest on the Indian subcontinent. The pathophysiology of this increased risk is complex, multifactorial, and its magnitude increases with migration from India to B
Externí odkaz:
https://doaj.org/article/dc65d53f5c78456e8eaee7d4c04e075a
Autor:
Harshal A. Deshmukh, Helen M. Colhoun, Toby Johnson, Paul M. McKeigue, D. John Betteridge, Paul N. Durrington, John H. Fuller, Shona Livingstone, Valentine Charlton-Menys, Andrew Neil, Neil Poulter, Peter Sever, Denis C. Shields, Alice V. Stanton, Aurobindo Chatterjee, Craig Hyde, Roberto A. Calle, David A. DeMicco, Stella Trompet, Iris Postmus, Ian Ford, J. Wouter Jukema, Mark Caulfield, Graham A. Hitman
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 5, Pp 1000-1011 (2012)
We carried out a genome-wide association study (GWAS) of LDL-c response to statin using data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n = 1,156), the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT; n = 895), and th
Externí odkaz:
https://doaj.org/article/0e30b62ae4ad49fe9ad70c633f99fac3
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
High-density lipoprotein (HDL) provides a pathway for the passage of lipid peroxides and lysophospholipids to the liver via hepatic scavenger receptors. Perhaps more importantly, HDL actually metabolises lipid hydroperoxides preventing their accumula
Externí odkaz:
https://doaj.org/article/597b9b3900574a0288cebe8a8090227b
Autor:
S E, Humphries, J A, Cooper, M, Seed, N, Capps, P N, Durrington, B, Jones, I F W, McDowell, H, Soran, H A W, Neil
Publikováno v:
Atherosclerosis
Background and aims Patients with familial hypercholesterolaemia (FH) have an elevated risk of coronary heart disease (CHD). Here we compare changes in CHD mortality in patients with heterozygous (FH) pre 1992, before lipid-lowering therapy with stat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::788468c0010f2e591ae97481d26025ad
https://pubmed.ncbi.nlm.nih.gov/29751283
https://pubmed.ncbi.nlm.nih.gov/29751283
Autor:
V. Charlton-Menys, D. J. Betteridge, H. Colhoun, J. Fuller, M. France, G. A. Hitman, S. J. Livingstone, H. A. W. Neil, C. B. Newman, M. Szarek, D. A. DeMicco, P. N. Durrington
AIMS/HYPOTHESIS: Controversy surrounds whether the ratio of apolipoprotein B (ApoB) to apolipoprotein A-I (ApoA-I) is the best lipoprotein discriminator of CHD risk in non-diabetic populations, but the issue has never been investigated in type 2 diab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe853daafe75a03ef73d16359bca44f
https://ora.ox.ac.uk/objects/uuid:7f7d17bd-f4b6-4a7e-8ad9-014b808e5f09
https://ora.ox.ac.uk/objects/uuid:7f7d17bd-f4b6-4a7e-8ad9-014b808e5f09
Autor:
P. N. Durrington, V. Charlton-Menys
Publikováno v:
Experimental Physiology. 93:27-42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d31d47a57a9d1a8086315debacfdc42e
https://doi.org/10.1113/expphysiol.2006.035147
https://doi.org/10.1113/expphysiol.2006.035147