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pro vyhledávání: '"P Michael, Conn"'
Autor:
P. Michael Conn
Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, ani
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181830 (2017)
Pharmacoperones are small molecules that diffuse into cells and rescue misfolded, mistrafficked protein mutants, restoring their function. These substances act with high target specificity, serving as templates to fold (or refold) receptors, enzymes,
Externí odkaz:
https://doaj.org/article/9939f7dc96484658b89bc7627cbce5e3
Autor:
P. Michael Conn, F.T. Rantin
Publikováno v:
Brazilian Journal of Medical and Biological Research, Vol 43, Iss 2, Pp 124-126 (2010)
Animal extremism has been increasing worldwide; frequently researchers are the targets of actions by groups with extreme animal rights agendas. Sometimes this targeting is violent and may involve assaults on family members or destruction of property.
Externí odkaz:
https://doaj.org/article/53f8eaa30a7241e78f1d4b5dc6f7a094
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22784 (2011)
Functional rescue of misfolded mutant receptors by small non-peptide molecules has been demonstrated. These small, target-specific molecules (pharmacological chaperones or "pharmacoperones") serve as molecular templates, promote correct folding and a
Externí odkaz:
https://doaj.org/article/b371851768b6464a8058657103fea775
Autor:
Michelle Re, Macarena Pampillo, Martin Savard, Céléna Dubuc, Craig A McArdle, Robert P Millar, P Michael Conn, Fernand Gobeil, Moshmi Bhattacharya, Andy V Babwah
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11489 (2010)
The mammalian type I gonadotropin releasing hormone receptor (GnRH-R) is a structurally unique G protein-coupled receptor (GPCR) that lacks cytoplasmic tail sequences and displays inefficient plasma membrane expression (PME). Compared to its murine c
Externí odkaz:
https://doaj.org/article/0d60d3ede10340949374b541eaa8c83f
Autor:
Shurong Hou, Timothy P. Spicer, Louis Scampavia, Franck Madoux, Jo Ann Janovick, P. Michael Conn
Publikováno v:
SLAS Discovery. 22:887-896
Primary hyperoxaluria is the underlying cause of oxalosis and is a life-threatening autosomal recessive disease, for which treatment may require dialysis or dual liver-kidney transplantation. The most common primary hyperoxaluria type 1 (PH1) is caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273d9d8a1eda1af3da3491d98ce29da7
https://doi.org/10.1177/2472555217689992
https://doi.org/10.1177/2472555217689992
Autor:
Jo Ann Janovick, Terry P. Kenakin, Emery Smith, Louis Scampavia, P. Michael Conn, Thomas D. Bannister, Timothy P. Spicer
Publikováno v:
Molecular and Cellular Endocrinology. 434:176-185
Pharmacoperones rescue misrouted mutants of the vasopressin receptor type 2 (V2R) and enable them to traffic to the correct biological locus where they function. Previously, a library of nearly 645,000 structures was interrogated with a high throughp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1793280f6d0ec06f76db5f42dc06e1
https://doi.org/10.1016/j.mce.2016.07.003
https://doi.org/10.1016/j.mce.2016.07.003
Autor:
Alfredo Ulloa-Aguirre, P. Michael Conn
Publikováno v:
Current Drug Targets. 17:1471-1481
In many conformational diseases caused by protein mutations, the intracellular traffic of the misfolded protein is compromised, leading to reduced or abolished function of the affected protein. Pharmacoperones (from "pharmacological chaperones") are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc41e893e4657f4a013ab31eb68d4b45
https://doi.org/10.2174/1389450117666160307143345
https://doi.org/10.2174/1389450117666160307143345
Autor:
Louis Scampavia, Emery Smith, Justin Shumate, Jo Ann Janovick, P. Michael Conn, Thomas D. Bannister, Timothy P. Spicer
Publikováno v:
SLAS Discovery. 21:824-831
Pharmacoperones correct the folding of otherwise misfolded protein mutants, restoring function (i.e., providing "rescue") by correcting their trafficking. Currently, most pharmacoperones possess intrinsic antagonist activity because they were identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3c3a0e9092f4c68221d9c8650d41fb
https://doi.org/10.1177/1087057116653925
https://doi.org/10.1177/1087057116653925
Autor:
Jeffrey L. Ram, P. Michael Conn
Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approa