Zobrazeno 1 - 10
of 499
pro vyhledávání: '"P Meera Khan"'
Autor:
M. D. Gupte, M. C. Vaidya, Narinder K. Mehra, J.J. van Rood, R. R. P. De Vries, P. Meera Khan
Publikováno v:
Tissue Antigens. 16:294-304
In an attempt to confirm an HLA-linked effect on the course of Mycobacterium leprae infection observed in families from Surinam (South America), we conducted a similar family study in an endemic area in India. We observed a significant (P less than .
Orientation of major histocompatibility (MHC) genes relative to the centromere of human chromosome 6
Publikováno v:
Clinical Genetics. 15:198-202
Linkage analysis of the data obtained from a three-generation Dutch family segregating for genetic variants of centromeric heterochromatic region in the band pi 1 on chromosome 6 (6ph), major histocompatibility (MHC) genes HLA-A, HLA-B and HLA-C, gly
Autor:
Riccardo Fodde, Raju Kucherlapati, Kristi L. Neufeld, P. Meera Khan, Ron Smits, Ray White, Cor Breukel, Winfried Edelmann, Menno F. Kielman, Nandy Hofland, Shantie Jagmohan-Changur, Jaap E. van Dijk, Chris Zurcher
Publikováno v:
Scopus-Elsevier
Genes and Development, 13(10), 1309-1321. Cold Spring Harbor Laboratory Press
Genes and Development, 13(10), 1309-1321. Cold Spring Harbor Laboratory Press
The adenomatous polyposis coli (APC) gene is considered as the true gatekeeper of colonic epithelial proliferation: It is mutated in the majority of colorectal tumors, and mutations occur at early stages of tumor development in mouse and man. These m
Publikováno v:
Scopus-Elsevier
Colorectal cancer still represents one of the most common causes of morbidity and mortality among Western populations. The adenomatous polyposis coli (APC) gene, originally identified as the gene responsible for familial adenomatous polyposis (FAP),
Autor:
Fred H. Menko, Eric Buskens, Gerrit Griffioen, Hans F. A. Vasen, P. Meera Khan, Jan K. Kleibeuker, Babs G. Taal, Marjolein van Ballegooijen, Fokko M. Nagengast
Publikováno v:
Cancer. 82:1632-1637
9oscopy every 2 ‐ 3 years, and 2) no CRC surveillance. Estimates of the lifetime risk of developing CRC and the stage distribution of CRC for symptomatic patients were 1 The Netherlands Foundation for the Detection derived from the Dutch hereditary
Autor:
Kirkland Lau, Riccardo Fodde, Kan Yang, Winfried Edelmann, Venkateswara R. Kolli, Martin Lipkin, Kunhua Fan, P. Meera Khan, Raju Kucherlapati
Publikováno v:
The Journal of Experimental Zoology. 277:245-254
In an effort to generate a good mouse model for human colorectal cancer, we generated mice which carry a mutation in the adenomatous polyposis coli (Apc) gene. Mice which are heterozygous for the mutation, designated Apc1638, develop colonic polyps a
Autor:
Rob. B. van der Luijt, P. Meera Khan, Hans F.A. Vasen, Carli M.J. Tops, Inge S.J. van Leeuwen‐Cornelisse, Juul Th. Wijnen, Heleen M. van der Klift, Rob J. Plug, Gerrit Griffioen, Riccardo Fodde
Publikováno v:
Human Mutation. 9:7-16
Autor:
Cor Breukel, Heleen M. van der Klift, Rob B. van der Luijt, P. Meera Khan, Hans F. A. Vasen, Riccardo Fodde, Pleun Snel, Carli M. J. Tops, Inge van Leeuwen-Cornelisse, Frederik J. M. Slors, Ellen Van Noort, Geoffrey C. Beverstock, Hans G. Dauwerse
Publikováno v:
Genes, Chromosomes and Cancer. 13:192-202
Familial adenomatous polyposis (FAP) is an inherited predisposition to colorectal cancer caused by germline mutations in the adenomatous polyposis coli (APC) gene located on chromosome segment 5q21-q22. We detected a germline rearrangement of the APC
Autor:
R. S. Cornells, H. F. A. Vasen, H. Meijers-Heijboer, D. Ford, M. van Vliet, A. A. G. van Tilborg, F. J. Cleton, J. G. M. Klijn, F. H. Menko, P. Meera Khan, C. J. Cornelisse, P. Devilee
Publikováno v:
Human genetics, 95(5), 539-544. Springer Verlag
We searched for criteria that could indicate breast cancer families with a high prior probability of being caused by the breast/ovarian cancer susceptibility locus BRCA1 on chromosome 17. To this end, we performed a linkage study with 59 consecutivel