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Akademický článek

Bicarbonate Inhibits Bacterial Growth and Biofilm Formation of Prevalent Cystic Fibrosis Pathogens

Autor: Orsolya Dobay, Krisztina Laub, Balázs Stercz, Adrienn Kéri, Bernadett Balázs, Adrienn Tóthpál, Szilvia Kardos, Pongsiri Jaikumpun, Kasidid Ruksakiet, Paul M. Quinton, Ákos Zsembery

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)

We investigated the effects of bicarbonate on the growth of several different bacteria as well as its effects on biofilm formation and intracellular cAMP concentration in Pseudomonas aeruginosa. Biofilm formation was examined in 96-well plates, with

Externí odkaz: https://doaj.org/article/79880d0a049f4a04b5e4e6de889fc285

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Akademický článek

Effects of dietary fish meal and soybean meal on the ovine innate and acquired immune response during pregnancy and lactation

Autor: J.A. Stryker, R. Fisher, Q. You, M.M. Or-Rashid, H.J. Boermans, M. Quinton, B.W. McBride, N.A. Karrow

Publikováno v: Animal, Vol 7, Iss 1, Pp 151-159 (2013)

In recent years, livestock producers have been supplementing animal diets with fish meal (FM) to produce value-added products for health conscious consumers. As components of FM have unique neuroendocrine–immunomodulatory properties, we hypothesize

Externí odkaz: https://doaj.org/article/18f4e22bacb44f2ab114d9ce6f21859d

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Iontophoretic beta-adrenergic stimulation of human sweat glands: possible assay for cystic fibrosis transmembrane conductance regulator activity in vivo

Autor: A K M, Shamsuddin, M M, Reddy, P M, Quinton

Publikováno v: Experimental physiology. 93(8)

With the advent of numerous candidate drugs for therapy in cystic fibrosis (CF), there is an urgent need for easily interpretable assays for testing their therapeutic value. Defects in the cystic fibrosis transmembrane conductance regulator (CFTR) ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0bf0d9e88da465420679215217468098
https://pubmed.ncbi.nlm.nih.gov/18441335

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Salivary secretion assay for drug efficacy for cystic fibrosis in mice

Autor: John Adam, Best, P M, Quinton

Publikováno v: Experimental physiology. 90(2)

Computerized assays on cultured cells ex vivo have been used to screen thousands of compounds for their effectiveness in correcting the basic physiological defect in cystic fibrosis (CF). While a number of these compounds appear promising, their effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54e8411a30e2595f53519ca2ee74bed4
https://pubmed.ncbi.nlm.nih.gov/15572461

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Effects of a new cystic fibrosis transmembrane conductance regulator inhibitor on Cl- conductance in human sweat ducts

Autor: X F, Wang, M M, Reddy, P M, Quinton

Publikováno v: Experimental physiology. 89(4)

Effective and specific inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel in epithelia has long been needed to better understand the role of anion movements in fluid and electrolyte transport. Until now, availabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99cb830bb5aed63911e69c2c313fe05d
https://pubmed.ncbi.nlm.nih.gov/15131065

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Selective activation of cystic fibrosis transmembrane conductance regulator Cl- and HCO3- conductances

Autor: M M, Reddy, P M, Quinton

Publikováno v: JOP : Journal of the pancreas. 2

While cystic fibrosis transmembrane conductance regulator (CFTR) is well known to function as a Cl(-) channel, some mutations in the channel protein causing cystic fibrosis (CF) disrupt another vital physiological function, HCO(3)(-) transport. Patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e4a7a5ef73f71e64aec7766cf50d3e7c
https://pubmed.ncbi.nlm.nih.gov/11875262

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Regulation of absorption by phosphorylation of CFTR

Autor: P M, Quinton, M M, Reddy

Publikováno v: The Japanese journal of physiology. 44

In contrast to fluid secretion which in many tissues is well known to be regulated by phosphorylation, little is known of phosphorylation regulation of electrolyte absorption. It is now well established that CFTR (cystic fibrosis transmembrane regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::572d6aca8b1bf225500bbc86a4bd758e
https://pubmed.ncbi.nlm.nih.gov/7538608

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