Experimental Evidence of the Antitumor, Antimetastatic and Antiangiogenic Activity of Ellagic Acid

Autor: Claudia Ceci, Pedro M. Lacal, Lucio Tentori, Maria Gabriella De Martino, Roberto Miano, Grazia Graziani

Publikováno v: Nutrients, Vol 10, Iss 11, p 1756 (2018)

Ellagic acid (EA) is a naturally occurring polyphenolic compound endowed with strong antioxidant and anticancer properties that is present in high quantity in a variety of berries, pomegranates, and dried fruits. The antitumor activity of EA has been

Externí odkaz: https://doaj.org/article/880cb877007f4bb3a2939eb3f397d2c7

Photoreceptor avascular privilege is shielded by soluble VEGF receptor-1

Autor: Ling Luo, Hironori Uehara, Xiaohui Zhang, Subrata K Das, Thomas Olsen, Derick Holt, Jacquelyn M Simonis, Kyle Jackman, Nirbhai Singh, Tadashi R Miya, Wei Huang, Faisal Ahmed, Ana Bastos-Carvalho, Yun Zheng Le, Christina Mamalis, Vince A Chiodo, William W Hauswirth, Judit Baffi, Pedro M Lacal, Angela Orecchia, Napoleone Ferrara, Guangping Gao, Kim Young-hee, Yingbin Fu, Leah Owen, Romulo Albuquerque, Wolfgang Baehr, Kirk Thomas, Dean Y Li, Kakarla V Chalam, Masabumi Shibuya, Salvatore Grisanti, David J Wilson, Jayakrishna Ambati, Balamurali K Ambati

Publikováno v: eLife, Vol 2 (2013)

Optimal phototransduction requires separation of the avascular photoreceptor layer from the adjacent vascularized inner retina and choroid. Breakdown of peri-photoreceptor vascular demarcation leads to retinal angiomatous proliferation or choroidal n

Externí odkaz: https://doaj.org/article/fd70fbe1df704e1b9a63339afb2fa5a4

Sox2 is not required for melanomagenesis, melanoma growth and melanoma metastasis in vivo

Autor: Emmanuele A. Jannini, Silvia K. Nicolis, Simona Caporali, Valeriana Cesarini, Antonio Costanzo, Federica Todaro, Susanna Dolci, Rebecca Favaro, Pellegrino Rossi, Elisabetta Botti, P M Lacal, Eugenia Guida, V Tassinari, S Di Agostino

Publikováno v: Oncogene (Basingstoke) 36 (2017): 4508–4515. doi:10.1038/onc.2017.53
info:cnr-pdr/source/autori:Cesarini, V.; Guida, E.; Todaro, F.; Di Agostino, S.; Tassinari, V.; Nicolis, S.; Favaro, R.; Caporali, S.; Lacal, P. M.; Botti, E.; Costanzo, A.; Rossi, P.; Jannini, E. A.; Dolci, S./titolo:Sox2 is not required for melanomagenesis, melanoma growth and melanoma metastasis in vivo/doi:10.1038%2Fonc.2017.53/rivista:Oncogene (Basingstoke)/anno:2017/pagina_da:4508/pagina_a:4515/intervallo_pagine:4508–4515/volume:36

Melanoma is a dangerous form of skin cancer derived from the malignant transformation of melanocytes. The transcription factor SOX2 is not expressed in melanocytes, however, it has been shown to be differentially expressed between benign nevi and mal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4fc57005c687d939c0f89577236eac6

Expression of the soluble vascular endothelial growth factor receptor-1 in cutaneous melanoma: role in tumour progression

Autor: F, Ruffini, C M, Failla, A, Orecchia, M R, Bani, A S, Dorio, C, Fortes, G, Zambruno, G, Graziani, R, Giavazzi, S, D'Atri, P M, Lacal

Publikováno v: The British journal of dermatology. 164(5)

Vascular endothelial growth factor (VEGF)-A, placenta growth factor (PlGF) and their corresponding membrane receptors are involved in autocrine and paracrine regulation of melanoma growth and metastasis. Besides the membrane receptors, a soluble form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4169c171d9f922208a1d251e165afe30
https://pubmed.ncbi.nlm.nih.gov/21198538

Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets

Autor: Keith C. Robbins, P M Lacal, J S Gutkind

Publikováno v: ResearcherID

Recent studies have shown that ligand-activated growth factor receptors as well as transforming versions of nonreceptor protein-tyrosine kinases physically associate with phosphatidylinositol-3 kinase (PI-3 kinase). Reasoning that PI-3 kinase might a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0fa8b3177ff38aa822fce1c052eda7
https://doi.org/10.1128/mcb.10.7.3806