Zobrazeno 1 - 10
of 77
pro vyhledávání: '"P M Hyde"'
Autor:
Nicholas J. Eagles, Svitlana V. Bach, Madhavi Tippani, Prashanthi Ravichandran, Yufeng Du, Ryan A. Miller, Thomas M. Hyde, Stephanie C. Page, Keri Martinowich, Leonardo Collado-Torres
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Visium is a widely-used spatially-resolved transcriptomics assay available from 10x Genomics. Standard Visium capture areas (6.5mm by 6.5mm) limit the survey of larger tissue structures, but combining overlapping images and associ
Externí odkaz:
https://doaj.org/article/d272854e1cd44ad7b58bc18c2d6c72ba
Autor:
Qiang Chen, Luis Aguirre, Guoming Liang, Huanhuan Zhao, Tao Dong, Felix Borrego, Itziar de Rojas, Qichan Hu, Christopher Reyes, Ling-Yan Su, Bao Zhang, James D. Lechleiter, Harald H. H. Göring, Philip L. De Jager, Joel E. Kleinman, Thomas M. Hyde, Pan P. Li, Agustín Ruiz, Daniel R. Weinberger, Sudha Seshadri, Liang Ma
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract Background The APOE gene is the strongest genetic risk factor for late-onset Alzheimer’s Disease (LOAD). However, the gene regulatory mechanisms at this locus remain incompletely characterized. Methods To identify novel AD-linked functiona
Externí odkaz:
https://doaj.org/article/5374844758ed40dc95d178d7f3ae89ee
Autor:
Kynon J. M. Benjamin, Ria Arora, Arthur S. Feltrin, Geo Pertea, Hunter H. Giles, Joshua M. Stolz, Laura D’Ignazio, Leonardo Collado-Torres, Joo Heon Shin, William S. Ulrich, Thomas M. Hyde, Joel E. Kleinman, Daniel R. Weinberger, Apuã C. M. Paquola, Jennifer A. Erwin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Schizophrenia is a complex neuropsychiatric disorder with sexually dimorphic features, including differential symptomatology, drug responsiveness, and male incidence rate. Prior large-scale transcriptome analyses for sex differences in schiz
Externí odkaz:
https://doaj.org/article/47464cd135894227b475555e891742ed
Autor:
Leonardo Sportelli, Daniel P. Eisenberg, Roberta Passiatore, Enrico D’Ambrosio, Linda A. Antonucci, Jasmine S. Bettina, Qiang Chen, Aaron L. Goldman, Michael D. Gregory, Kira Griffiths, Thomas M. Hyde, Joel E. Kleinman, Antonio F. Pardiñas, Madhur Parihar, Teresa Popolizio, Antonio Rampino, Joo Heon Shin, Mattia Veronese, William S. Ulrich, Caroline F. Zink, Alessandro Bertolino, Oliver D. Howes, Karen F. Berman, Daniel R. Weinberger, Giulio Pergola
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic risk funnels through these pathways to translate into syndromic illness. Using tensor decom
Externí odkaz:
https://doaj.org/article/bdf3671448254ff98814912fb8b64f61
Autor:
Ethan Tietze, Andre Rocha Barbosa, Bruno Araujo, Veronica Euclydes, Bailey Spiegelberg, Hyeon Jin Cho, Yong Kyu Lee, Yanhong Wang, Alejandra McCord, Alan Lorenzetti, Arthur Feltrin, Joyce van de Leemput, Pasquale Di Carlo, Gianluca Ursini, Kynon J. Benjamin, Helena Brentani, Joel E. Kleinman, Thomas M. Hyde, Daniel R. Weinberger, Ronald McKay, Joo Heon Shin, Tomoyo Sawada, Apua C. M. Paquola, Jennifer A. Erwin
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Primary human trophoblast stem cells (TSCs) and TSCs derived from human pluripotent stem cells (hPSCs) can potentially model placental processes in vitro. Yet, the pluripotent states and factors involved in the differentiation of hPSCs to TS
Externí odkaz:
https://doaj.org/article/6bb7441979f6437cb464f3a0916c266a
Autor:
Laura V. Randall, Dong-Hyun Kim, Salah M.A. Abdelrazig, Nicola J. Bollard, Heather Hemingway-Arnold, Robert M. Hyde, Jake S. Thompson, Martin J. Green
Publikováno v:
Journal of Dairy Science, Vol 106, Iss 10, Pp 7033-7042 (2023)
ABSTRACT: Lameness in dairy cattle is a highly prevalent condition that impacts on the health and welfare of dairy cows. Prompt detection and implementation of effective treatment is important for managing lameness. However, major limitations are ass
Externí odkaz:
https://doaj.org/article/e0e426bf9c5243e4bba6f5d6c92922d4
Autor:
Lukas M Weber, Heena R Divecha, Matthew N Tran, Sang Ho Kwon, Abby Spangler, Kelsey D Montgomery, Madhavi Tippani, Rahul Bharadwaj, Joel E Kleinman, Stephanie C Page, Thomas M Hyde, Leonardo Collado-Torres, Kristen R Maynard, Keri Martinowich, Stephanie C Hicks
Publikováno v:
eLife, Vol 12 (2024)
Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections throughout the central nervous system, playing critical roles in arousal and mood, as well as various components of cognition including attention, learning, and memor
Externí odkaz:
https://doaj.org/article/5535bef8bfda4d938789135e8f5f9d86
Publikováno v:
BMC Health Services Research, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Standardized order sets are a means of increasing adherence to clinical practice guidelines and improving the quality of patient care. Implementation of novel quality improvement initiatives like order sets can be challenging. Bef
Externí odkaz:
https://doaj.org/article/bd6288a4ff904f6d9a2c46fbd2245c0c
Autor:
Eugenia Radulescu, Qiang Chen, Giulio Pergola, Pasquale Di Carlo, Shizhong Han, Joo Heon Shin, Thomas M Hyde, Joel E Kleinman, Daniel R Weinberger
Publikováno v:
PLoS Genetics, Vol 19, Iss 10, p e1010989 (2023)
The effect of schizophrenia (SCZ) genetic risk on gene expression in brain remains elusive. A popular approach to this problem has been the application of gene co-expression network algorithms (e.g., WGCNA). To improve reliability with this method it
Externí odkaz:
https://doaj.org/article/5b4e1686789a4b1b9371751ae2a7254d
Autor:
Vijay Sadashivaiah, Madhavi Tippani, Stephanie C. Page, Sang Ho Kwon, Svitlana V. Bach, Rahul A. Bharadwaj, Thomas M. Hyde, Joel E. Kleinman, Andrew E. Jaffe, Kristen R. Maynard
Publikováno v:
BMC Neuroscience, Vol 24, Iss 1, Pp 1-20 (2023)
Abstract Background Multispectral fluorescence imaging coupled with linear unmixing is a form of image data collection and analysis that allows for measuring multiple molecular signals in a single biological sample. Multiple fluorescent dyes, each me
Externí odkaz:
https://doaj.org/article/0dfa134e9c79402a844b850026892a27