Functional in-vitro evaluation of the non-specific effects of BCG vaccination in a randomised controlled clinical study

Autor: Morven Wilkie, Rachel Tanner, Daniel Wright, Raquel Lopez Ramon, Julia Beglov, Michael Riste, Julia L. Marshall, Stephanie A. Harris, Paulo J. G. Bettencourt, Ali Hamidi, Pauline M. van Diemen, Paul Moss, Iman Satti, David Wyllie, Helen McShane

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract Bacille Calmette-Guérin (BCG), the only currently licenced tuberculosis vaccine, may exert beneficial non-specific effects (NSE) in reducing infant mortality. We conducted a randomised controlled clinical study in healthy UK adults to evalu

Externí odkaz: https://doaj.org/article/92ca1e31f3be4c04bef9da9dacee16dd

Interspecies Transmission of Reassortant Swine Influenza A Virus Containing Genes from Swine Influenza A(H1N1)pdm09 and A(H1N2) Viruses

Autor: Helen E. Everett, Bethany Nash, Brandon Z. Londt, Michael D. Kelly, Vivien Coward, Alejandro Nunez, Pauline M. van Diemen, Ian H. Brown, Sharon M. Brookes

Publikováno v: Emerging Infectious Diseases, Vol 26, Iss 2, Pp 273-281 (2020)

Influenza A(H1N1)pdm09 (pH1N1) virus has become established in swine in the United Kingdom and currently co-circulates with previously enzootic swine influenza A virus (IAV) strains, including avian-like H1N1 and human-like H1N2 viruses. During 2010,

Externí odkaz: https://doaj.org/article/a26adb16e6c74cdd9b33ffaaae10e82f

The S. aureus 4-oxalocrotonate tautomerase SAR1376 enhances immune responses when fused to several antigens

Autor: Pauline M. van Diemen, Darren B. Leneghan, Iona J. Brian, Kazutoyo Miura, Carole A. Long, Anita Milicic, Sumi Biswas, Christine S. Rollier, David H. Wyllie

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Abstract A persistent goal of vaccine development is the enhancement of the immunogenicity of antigens while maintaining safety. One strategy involves alteration of the presentation of the antigen by combining antigens with a multimeric scaffold. Mul

Externí odkaz: https://doaj.org/article/9486e757e39243498c51768ecb873839

Comprehensive assignment of roles for Salmonella typhimurium genes in intestinal colonization of food-producing animals.

Autor: Roy R Chaudhuri, Eirwen Morgan, Sarah E Peters, Stephen J Pleasance, Debra L Hudson, Holly M Davies, Jinhong Wang, Pauline M van Diemen, Anthony M Buckley, Alison J Bowen, Gillian D Pullinger, Daniel J Turner, Gemma C Langridge, A Keith Turner, Julian Parkhill, Ian G Charles, Duncan J Maskell, Mark P Stevens

Publikováno v: PLoS Genetics, Vol 9, Iss 4, p e1003456 (2013)

Chickens, pigs, and cattle are key reservoirs of Salmonella enterica, a foodborne pathogen of worldwide importance. Though a decade has elapsed since publication of the first Salmonella genome, thousands of genes remain of hypothetical or unknown fun

Externí odkaz: https://doaj.org/article/7820bce80403457dbb9f2d7f151160b7

Administration of Lactobacillus johnsonii FI9785 to chickens affects colonisation by Campylobacter jejuni and the intestinal microbiota

Autor: C. Pin, P. M. van Diemen, R. Mañes-Lázaro, M. J. Mayer, A. Narbad, Mark P. Stevens

Publikováno v: Mañes-Lázaro, R, Van Diemen, P M, Pin, C, Mayer, M J, Stevens, M P & Narbad, A 2017, ' Administration of Lactobacillus johnsonii FI9785 to chickens affects colonisation by Campylobacter jejuni and the intestinal microbiota ', British Poultry Science, vol. 58, no. 4, pp. 373-381 . https://doi.org/10.1080/00071668.2017.1307322

1. Campylobacter jejuni is the most common bacterial cause of human food-borne gastroenteritis in the world. A major source of human infection is the consumption of contaminated meat, particularly poultry. New control measures to reduce or eliminate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8258241fe6d8f1aca016cc9050c45912
https://doi.org/10.1080/00071668.2017.1307322