Zobrazeno 1 - 10
of 1 081
pro vyhledávání: '"P M, Walker"'
Autor:
Amy L. Gillespie, Emma M. Walker, Eilis Hannon, Grant A. McQueen, Kyra-Verena Sendt, Alessia Avila, John Lally, Cynthia Okhuijsen-Pfeifer, Marte van der Horst, Alkomiet Hasan, Emma L. Dempster, Joe Burrage, Jan Bogers, Dan Cohen, Marco P. Boks, David A. Collier, Alice Egerton, Jurjen J. Luykx, Jonathan Mill, James H. MacCabe
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The second-generation antipsychotic clozapine is used as a medication for treatment-resistant schizophrenia. It has previously been associated with epigenetic changes in pre-clinical rodent models and cross-sectional studies of treatment-res
Externí odkaz:
https://doaj.org/article/10cc9b0526224bc0a4cf3fb043bfa0a3
Autor:
Georgina B. F. Hall, Rachael Birkbeck, Benjamin M. Brainard, Fernanda Camacho, Elizabeth B. Davidow, Dana N. LeVine, Andrew Mackin, Taylor Moss, Katherine J. Nash, Giacomo Stanzani, Daria Starybrat, David Q. Stoye, Carolyn Tai, John Thomason, Julie M. Walker, K. Jane Wardrop, Helen Wilson, Virginie A. Wurlod, Karen Humm
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 38, Iss 5, Pp 2495-2506 (2024)
Abstract Background Reported incidence of blood transfusion reactions (TR) varies greatly. Objective To prospectively evaluate the incidence of acute TRs in dogs receiving allogenic blood products, using consensus definitions, and to assess factors a
Externí odkaz:
https://doaj.org/article/fa536a4ec50a47b1bbf67a6e84e846b7
Autor:
Danni A. Gadd, Hannah M. Smith, Donncha Mullin, Ola Chybowska, Robert F. Hillary, Dorien M. Kimenai, Elena Bernabeu, Yipeng Cheng, Chloe Fawns-Ritchie, Archie Campbell, Danielle Page, Adele Taylor, Janie Corley, Maria Del C. Valdés-Hernández, Susana Muñoz Maniega, Mark E. Bastin, Joanna M. Wardlaw, Rosie M. Walker, Kathryn L. Evans, Andrew M. McIntosh, Caroline Hayward, Tom C. Russ, Sarah E. Harris, Paul Welsh, Naveed Sattar, Simon R. Cox, Daniel L. McCartney, Riccardo E. Marioni
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Plasma growth differentiation factor 15 (GDF15) and N‐terminal proB‐type natriuretic peptide (NT‐proBNP) are cardiovascular biomarkers that associate with a range of diseases. Epigenetic scores (EpiScores) for GDF15 and NT-p
Externí odkaz:
https://doaj.org/article/76e8233ab631452ab514eb985f52d351
Autor:
Lauren M. Walker, Carly S. Sears, Erik Wibowo, John W. Robinson, Andrew G. Matthew, Deborah L. McLeod, Richard J. Wassersug
Publikováno v:
Current Oncology, Vol 31, Iss 9, Pp 5040-5056 (2024)
Although Androgen Deprivation Therapy (ADT) is effective in controlling prostate cancer (PCa) and increasing survival, it is associated with a myriad of side effects that cause significant morbidity. Previous research has shown that PCa patients star
Externí odkaz:
https://doaj.org/article/a61802cf2a5d46b49250f1fb1ac7e099
Autor:
Ailsa MacCalman, Elisa De Franco, Alice Franklin, Christine S. Flaxman, Sarah J. Richardson, Kathryn Murrall, Joe Burrage, Barts Pancreas Tissue Bank (BPTB), Emma M. Walker, Noel G. Morgan, Andrew T. Hattersley, Emma L. Dempster, Eilis Hannon, Aaron R. Jeffries, Nick D. L. Owens, Jonathan Mill
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Development of the human pancreas requires the precise temporal control of gene expression via epigenetic mechanisms and the binding of key transcription factors. We quantified genome-wide patterns of DNA methylation in human fetal pancreati
Externí odkaz:
https://doaj.org/article/ea742da1a75a4ea5b89b8681cb5b5745
Autor:
Joshua Ladau, Eoin L. Brodie, Nicola Falco, Ishan Bansal, Elijah B. Hoffman, Marcin P. Joachimiak, Ana M. Mora, Angelica M. Walker, Haruko M. Wainwright, Yulun Wu, Mirko Pavicic, Daniel Jacobson, Matthias Hess, James B. Brown, Katrina Abuabara
Publikováno v:
Infectious Disease Modelling, Vol 9, Iss 2, Pp 634-643 (2024)
Objectives: We aim to estimate geographic variability in total numbers of infections and infection fatality ratios (IFR; the number of deaths caused by an infection per 1,000 infected people) when the availability and quality of data on disease burde
Externí odkaz:
https://doaj.org/article/f319489268a0448ca817662d6bc9ed64
Autor:
Faye M. Walker, Lays Martin Sobral, Etienne Danis, Bridget Sanford, Sahiti Donthula, Ilango Balakrishnan, Dong Wang, Angela Pierce, Sana D. Karam, Soudabeh Kargar, Natalie J. Serkova, Nicholas K. Foreman, Sujatha Venkataraman, Robin Dowell, Rajeev Vibhakar, Nathan A. Dahl
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Dynamic regulation of gene expression is fundamental for cellular adaptation to exogenous stressors. P-TEFb-mediated pause-release of RNA polymerase II (Pol II) is a conserved regulatory mechanism for synchronous transcriptional induction in
Externí odkaz:
https://doaj.org/article/d56159185f7f4564adf980120f3ab2ba
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract We aimed to determine if continuous perioperative heart rate variability (HRV) monitoring could improve risk stratification compared to a short preoperative measurement in radical cystectomy patients. Electrocardiography (ECG) recordings wer
Externí odkaz:
https://doaj.org/article/cacae271cbf44ca98ba586a14472a537
Autor:
Rosie M. Walker, Michael Chong, Nicolas Perrot, Marie Pigeyre, Danni A. Gadd, Aleks Stolicyn, Liu Shi, Archie Campbell, Xueyi Shen, Heather C. Whalley, Alejo Nevado-Holgado, Andrew M. McIntosh, Stefan Heitmeier, Sumathy Rangarajan, Martin O’Donnell, Eric E. Smith, Salim Yusuf, William N. Whiteley, Guillaume Paré
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Decline in cognitive function is the most feared aspect of ageing. Poorer midlife cognitive function is associated with increased dementia and stroke risk. The mechanisms underlying variation in cognitive function are uncertain. Here, we ass
Externí odkaz:
https://doaj.org/article/edaf7fb177e34492a3507cce3b3d3eea
Autor:
Brian M. Petersen, Monica B. Kirby, Karson M. Chrispens, Olivia M. Irvin, Isabell K. Strawn, Cyrus M. Haas, Alexis M. Walker, Zachary T. Baumer, Sophia A. Ulmer, Edgardo Ayala, Emily R. Rhodes, Jenna J. Guthmiller, Paul J. Steiner, Timothy A. Whitehead
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Antibodies are engineerable quantities in medicine. Learning antibody molecular recognition would enable the in silico design of high affinity binders against nearly any proteinaceous surface. Yet, publicly available experiment antibody sequ
Externí odkaz:
https://doaj.org/article/ad885af6bfcd4b0ba2768a7ecb7b47e4