Zobrazeno 1 - 10
of 18
pro vyhledávání: '"P M, Vertino"'
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-15 (2021)
Abstract Background Chromatin state provides a clear decipherable blueprint for maintenance of transcriptional patterns, exemplifying a mitotically stable form of cellular programming in dividing cells. In this regard, genomic studies of chromatin st
Externí odkaz:
https://doaj.org/article/aa1bfdfef7ff43da918de63bfdef8ab7
Autor:
Hyerim Kim, Yunhee Kang, Yujing Li, Li Chen, Li Lin, Nicholas D. Johnson, Dan Zhu, M. Hope Robinson, Leon McSwain, Benjamin G. Barwick, Xianrui Yuan, Xinbin Liao, Jie Zhao, Zhiping Zhang, Qiang Shu, Jianjun Chen, Emily G. Allen, Anna M. Kenney, Robert C. Castellino, Erwin G. Van Meir, Karen N. Conneely, Paula M. Vertino, Peng Jin, Jian Li
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-25 (2021)
Abstract Background Medulloblastoma (MB) is the most common malignant pediatric brain tumor that originates in the cerebellum and brainstem. Frequent somatic mutations and deregulated expression of epigenetic regulators in MB highlight the substantia
Externí odkaz:
https://doaj.org/article/2c470edd61e44204bdc75332b31115e7
Autor:
Baotong Zhang, Yixiang Li, Qiao Wu, Lin Xie, Benjamin Barwick, Changying Fu, Xin Li, Daqing Wu, Siyuan Xia, Jing Chen, Wei Ping Qian, Lily Yang, Adeboye O. Osunkoya, Lawrence Boise, Paula M. Vertino, Yichao Zhao, Menglin Li, Hsiao-Rong Chen, Jeanne Kowalski, Omer Kucuk, Wei Zhou, Jin-Tang Dong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
The therapies for bone metastatic prostate cancer are limited and the underlying mechanisms are unclear. Here, the authors show that bone derived TGF-β induces acetylation of KLF5 (Ac-KLF5), and Ac-KLF5 promotes prostate cancer bone metastasis and r
Externí odkaz:
https://doaj.org/article/4767d9e2f20b432ab88e90cb4777af44
Autor:
Benjamin G. Barwick, Paola Neri, Nizar J. Bahlis, Ajay K. Nooka, Madhav V. Dhodapkar, David L. Jaye, Craig C. Hofmeister, Jonathan L. Kaufman, Vikas A. Gupta, Daniel Auclair, Jonathan J. Keats, Sagar Lonial, Paula M. Vertino, Lawrence H. Boise
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Multiple myeloma is frequently characterised by translocation of genes next to the immunoglobulin heavy chain locus. In this study, the authors sequence a large cohort of high risk myeloma samples and find translocations of cMyc to the immunoglobulin
Externí odkaz:
https://doaj.org/article/f7edb1aa7e034097bfaeab285876053f
Autor:
E. M. Kennedy, D. R. Powell, Z. Li, J. S. K. Bell, B. G. Barwick, H. Feng, M. R. McCrary, B. Dwivedi, J. Kowalski, W. S. Dynan, K. N. Conneely, P. M. Vertino
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Human deep space and planetary travel is limited by uncertainties regarding the health risks associated with exposure to galactic cosmic radiation (GCR), and in particular the high linear energy transfer (LET), heavy ion component. Here we a
Externí odkaz:
https://doaj.org/article/f87b1595000d46c19a007139a1f7607b
Autor:
Joshua S. K. Bell, Paula M. Vertino
Publikováno v:
Epigenetics, Vol 12, Iss 6, Pp 449-464 (2017)
CpG islands (CGI) are critical genomic regulatory elements that support transcriptional initiation and are associated with the promoters of most human genes. CGI are distinguished from the bulk genome by their high CpG density, lack of DNA methylatio
Externí odkaz:
https://doaj.org/article/f8d3bc1dfca145be97a2a8db11108a9d
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
B cell activation and differentiation yields plasma cells with high affinity antibodies to a given antigen in a time-frame that allows for host protection. Although the end product is most commonly humoral immunity, the rapid proliferation and somati
Externí odkaz:
https://doaj.org/article/880c386be0494892a9e824317a16aea3
Autor:
Rendong Yang, Li Chen, Scott Newman, Khanjan Gandhi, Gregory Doho, Carlos S. Moreno, Paula M. Vertino, Leon Bernal-Mizarchi, Sagar Lonial, Lawrence H. Boise, Michael Rossi, Jeanne Kowalski, Zhaohui S. Qin
Publikováno v:
Cancer Informatics, Vol 2014, Iss Suppl. 2, Pp 49-53 (2014)
Externí odkaz:
https://doaj.org/article/cdabd65336a14370982d6647b782b316
Autor:
Seth A Brodie, Courtney Lombardo, Ge Li, Jeanne Kowalski, Khanjan Gandhi, Shaojin You, Fadlo R Khuri, Adam Marcus, Paula M Vertino, Johann C Brandes
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107124 (2014)
Aberrant promoter DNA methylation can serve as a predictive biomarker for improved clinical responses to certain chemotherapeutics. One of the major advantages of methylation biomarkers is the ease of detection and clinical application. In order to i
Externí odkaz:
https://doaj.org/article/cc4fe30868cc44918af2125cbede5c97
Autor:
Zhen Yang, Anapatricia Garcia, Songli Xu, Doris R Powell, Paula M Vertino, Shivendra Singh, Adam I Marcus
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75069 (2013)
Though clinicians can predict which patients are at risk for developing metastases, traditional therapies often prove ineffective and metastatic disease is the primary cause of cancer patient death; therefore, there is a need to develop anti-metastat
Externí odkaz:
https://doaj.org/article/a7742008364146ddb1b746a5a5b08b69