Zobrazeno 1 - 10
of 148
pro vyhledávání: '"P M, Lim"'
Autor:
Jonathan K. M. Lim, Arash Samiei, Alberto Delaidelli, Jessica Oliveira de Santis, Vanessa Brinkmann, Christopher J. Carnie, Daniel Radiloff, Laura Hruby, Alisa Kahler, Jordan Cran, Gabriel Leprivier, Poul H. Sorensen
Publikováno v:
Cell Death and Disease, Vol 15, Iss 7, Pp 1-10 (2024)
Abstract Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a stress-responsive hub that inhibits the translation elongation factor eEF2, and consequently mRNA translation elongation, in response to hypoxia and nutrient deprivation. EEF2K is als
Externí odkaz:
https://doaj.org/article/6835837b84d7441fa2ee38d01cd997d9
Autor:
Tal Levy, Kai Voeltzke, Laura Hruby, Khawla Alasad, Zuelal Bas, Marteinn Snaebjörnsson, Ran Marciano, Katerina Scharov, Mélanie Planque, Kim Vriens, Stefan Christen, Cornelius M. Funk, Christina Hassiepen, Alisa Kahler, Beate Heider, Daniel Picard, Jonathan K. M. Lim, Anja Stefanski, Katja Bendrin, Andres Vargas-Toscano, Ulf D. Kahlert, Kai Stühler, Marc Remke, Moshe Elkabets, Thomas G. P. Grünewald, Andreas S. Reichert, Sarah-Maria Fendt, Almut Schulze, Guido Reifenberger, Barak Rotblat, Gabriel Leprivier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Energetic stress compels cells to evolve adaptive mechanisms to adjust their metabolism. Inhibition of mTOR kinase complex 1 (mTORC1) is essential for cell survival during glucose starvation. How mTORC1 controls cell viability during glucose
Externí odkaz:
https://doaj.org/article/b77120ef8e324fda80f5122560600dc1
Autor:
Karda Cavanagh, Luke S. McLean, Annette M. Lim, Anthony Cardin, Sidney M. Levy, Danny Rischin
Publikováno v:
Cancer Imaging, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Cutaneous squamous cell carcinoma (CSCC) has a propensity for perineural spread (PNS) which is associated with poorer treatment outcomes. Immunotherapy is the new standard of care treatment for advanced CSCC resulting in durable r
Externí odkaz:
https://doaj.org/article/a53d1392e6e24d3190ce18dea55dfaee
Autor:
Dirk Schadendorf, Thomas K Eigentler, Israel Lowy, Apostolos Papachristos, Samantha Bowyer, Friedegund Meier, Brigitte Dreno, Danny Rischin, Michael R Migden, Annette M Lim, Chrysalyne D Schmults, Brett G M Hughes, Axel Hauschild, Brian Stein, Emmanuel Okoye, Jocelyn Booth, Matthew G Fury, Alexander Guminski, Sophie Dalac, Frank Seebach, Marie Beylot-Barry, Suk-Young Yoo, Nicole Basset-Séguin, Sabiha Trabelsi Messai, Victoria Casado Echarren, Anne J Paccaly, Jenny-Hoa Nguyen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)
Background Cemiplimab (Libtayo®), a human monoclonal immunoglobulin G4 antibody to the programmed cell death-1 receptor, is approved for the treatment of patients with advanced cutaneous squamous cell carcinoma (CSCC), who are not candidates for cur
Externí odkaz:
https://doaj.org/article/85c0508e98f2481db714933c819add16
Autor:
Stacy Q. Y. Chong, Darren Yeo, Nur Insyirah Aidil, Jasmine L. Y. Ong, Amy H. J. Chan, Charlene Judith Fernandez, Bryan T. M. Lim, Max D. Y. Khoo, Anna M. S. Wong, Siow Foong Chang, Him Hoo Yap
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-9 (2023)
Abstract Background Babesia is a protozoal, tick-borne parasite that can cause life-threatening disease in humans, wildlife and domestic animals worldwide. However, in Southeast Asia, little is known about the prevalence and diversity of Babesia spec
Externí odkaz:
https://doaj.org/article/15a2225036c7476c8a54c69ea98a4c03
Autor:
Kevin B. L. Lim, Nicole K. L. Lee, Beatrice S. Yeo, Victoria M. M. Lim, Stacy W. L. Ng, Neeraj Mishra
Publikováno v:
Bone & Joint Open, Vol 4, Iss 9, Pp 689-695 (2023)
Aims: To determine whether side-bending films in scoliosis are assessed for adequacy in clinical practice; and to introduce a novel method for doing so. Methods: Six surgeons and eight radiographers were invited to participate in four online surveys.
Externí odkaz:
https://doaj.org/article/2182532401f7466a98bd12f691f31164
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 1008 (2024)
One aspect of reproducibility in preclinical research that is frequently overlooked is the physical condition in which physiological, pharmacological, or behavioural recordings are conducted. In this study, the physical conditions of mice were altere
Externí odkaz:
https://doaj.org/article/30cbaf1efa904314b2d2e7b0e7ee7522
Autor:
S.M. Cavallo, E. Pellencin, G. Carone, N. Castelli, R. Ayadi, A. Moiyadi, L. Padayachy, T.R. Meling, F. Di Meco, A. Perin, F. Olldashi, A. Al Anazi, I. Kanaan, F. Garcia Colmena, P. Ajler, M. Socolovsky, E. Knosp, C. Raftopoulos, J.C. Rodrigues, Jr., Y.P. Enchev, B. Xu, P. Chul-Kee, K. Rotim, J. Posti, B. Meyer, H. Shimamoto, Y. Makhambetov, J. Frosen, S.P. Chandra, P. Cappabianca, G. Piatelli, L. Genitori, A. Germanò, G. Sabatino, C. Bernucci, C. Giussani, A. Olivi, D. Locatelli, R. Stefini, C. Castrioto, A. Mangiola, M.M. Fontanella, L. Tacconi, C. Conti, M. Skrap, N. El Abbadi, M.R. Sharma, M.S. Shamim, S. Sharif, J.P. Farias, I.S. Florian, A.O. Gushcha, L. Rasulic, P. Vulekovic, B.T. Ang, A. Lagares, R. Diez Valle, J. Ensenat, L. Ley Urzaiz, J.A. Barcia Albacar, S.S. Kupanur, L. Regli, I.F. Dunn, D. Adelson, J. Bederson, A.D. Levi, A.Y. Alturky, C. Matula, B. Cortes, W. Xiang, T. Li, N.M.F. El-Ghandour, R. Kanai, R. Patir, B.K. Misra, S. Dwarakanath, F. Servadei, F. Tomasello, C. Casali, G. Unsgard, J.J. Morcos, T. Souhil, I. Khoja, I. Kehayov, M. Vukic, M. Ziebell, H.A. Gulisano, M. Tange, K. Kurozumi, M. Locatelli, D. Garbossa, J.L. Gomez Amador, A.O. Rodriguez, K. Ashkan, M. Lim, M. Maleki, A. Agrawal, A. Naik, D.M. Sciubba, L.J. Kim, R.J. Spinner, P. McDonald, G. Pavesi
Publikováno v:
Brain and Spine, Vol 4, Iss , Pp 102923- (2024)
Introduction: Neurosurgery is considered a technically demanding specialty; nonetheless, it also requires non-technical skills (NTSs) to reach mastery. Research question: This study seeks to understand how important NTSs are perceived by neurosurgeon
Externí odkaz:
https://doaj.org/article/29ac950e86a94670b5dda0ae9767aacb
Autor:
Lee E. Neilson, Nadir M. Balba, Jonathan E. Elliott, Gregory D. Scott, Scott D. Mist, Matthew P. Butler, Mary M. Heinricher, Miranda M. Lim
Publikováno v:
Clinical Parkinsonism & Related Disorders, Vol 10, Iss , Pp 100253- (2024)
Introduction: The research criteria for prodromal Parkinson disease (pPD) depends on prospectively validated clinical inputs with large effect sizes and/or high prevalence. Neither traumatic brain injury (TBI), post-traumatic stress disorder (PTSD),
Externí odkaz:
https://doaj.org/article/f3916a7923c6434c85f6f665afab754a
Autor:
Jonathan E. Elliott, Miranda M. Lim, Allison T. Keil, Ronald B. Postuma, Amelie Pelletier, Jean‐François Gagnon, Erik K. St. Louis, Leah K. Forsberg, Julie A. Fields, Daniel E. Huddleston, Donald L. Bliwise, Alon Y. Avidan, Michael J. Howell, Carlos H. Schenck, Jennifer McLeland, Susan R. Criswell, Aleksandar Videnovic, Emmanuel H. During, Mitchell G. Miglis, David R. Shprecher, Joyce K. Lee‐Iannotti, Bradley F. Boeve, Yo‐El S. Ju, the North American Prodromal Synucleinopathy (NAPS) Consortium
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 4, Pp 520-535 (2023)
Abstract Objective Rapid eye movement (REM) sleep behavior disorder (RBD) is widely considered a prodromal synucleinopathy, as most with RBD develop overt synucleinopathy within ~10 years. Accordingly, RBD offers an opportunity to test potential trea
Externí odkaz:
https://doaj.org/article/31d9613c029c455b8349abb5094f206a