Zobrazeno 1 - 10
of 57
pro vyhledávání: '"P M, Kochanek"'
Autor:
Ian G. Gober, Ashley L. Russell, Tyler J. Shick, Vincent A. Vagni, Jenna C. Carlson, Patrick M. Kochanek, Amy K. Wagner
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Uncontrolled neuroinflammation mediates traumatic brain injury (TBI) pathology and impairs recovery. Interleukin-6 (IL-6), a pleiotropic inflammatory regulator, is associated with poor clinical TBI outcomes. IL-6 operates via classical-signa
Externí odkaz:
https://doaj.org/article/203db4b4abdf484d8c8eb4b1304705c9
Autor:
Stephanie M. Helman, PhD, Susan Sereika, PhD, Marilyn Hravnak, PhD, RN, MCCM, Richard Henker, PhD, RN, CRNA, J. William Gaynor, MD, Elizabeth Herrup, MD, Robert Olsen, BS, Patrick M. Kochanek, MD, MCCM, Rod Ghassemzadeh, MD, Tracy Baust, BA, CCRC, Nathan T. Riek, PhD(c), Yuliya Domnina, MD, Amy Jo Lisanti, PhD, RN, CCNS, Salah Al-Zaiti, PhD
Publikováno v:
Critical Care Explorations, Vol 6, Iss 8, p e1137 (2024)
IMPORTANCE:. Persistent hypothermia after cardiopulmonary bypass (CPB) in neonates with congenital heart defects (CHD) has been historically considered benign despite lack of evidence on its prognostic significance. OBJECTIVES:. Examine associations
Externí odkaz:
https://doaj.org/article/2e1987bd65124eb3ac5afc00f0ed4c54
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-13 (2023)
Abstract It is not clear if inhibiting the pro-death gene RNA binding motif 5 (RBM5) is neuroprotective in isolated primary neurons or if it regulates cell survival in a sex-dependent manner. Here we established sex-dichotomized primary cortical neur
Externí odkaz:
https://doaj.org/article/9324602c3bd940028151f17b6468215b
Autor:
Jessica Cummings, Yijen L. Wu, C. Edward Dixon, Jeremy Henchir, J. Marc Simard, Ashok Panigrahy, Patrick M. Kochanek, Ruchira M. Jha, Rajesh K. Aneja
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-11 (2023)
Abstract Sepsis-associated brain injury (SABI) is characterized by an acute deterioration of mental status resulting in cognitive impairment and acquisition of new and persistent functional limitations in sepsis survivors. Previously, we reported tha
Externí odkaz:
https://doaj.org/article/09fef268cec240d990a9cc47f2ca7af1
Autor:
Jeremy R. Herrmann, Travis C. Jackson, Anthony Fabio, Robert S. B. Clark, Rachel P. Berger, Keri L. Janesko‐Feldman, Patrick M. Kochanek, Ericka L. Fink
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 15 (2023)
Externí odkaz:
https://doaj.org/article/f0573c145d3e4a39bc3e789e3cdd50d0
Autor:
Amery Treble-Barna, Bailey A. Petersen, Zachary Stec, Yvette P. Conley, Ericka L. Fink, Patrick M. Kochanek
Publikováno v:
Biomolecules, Vol 14, Iss 2, p 191 (2024)
We review emerging preclinical and clinical evidence regarding brain-derived neurotrophic factor (BDNF) protein, genotype, and DNA methylation (DNAm) as biomarkers of outcomes in three important etiologies of pediatric acquired brain injury (ABI), tr
Externí odkaz:
https://doaj.org/article/d5505fee8ec74c17a4ce5fd45d28a574
Autor:
Dennis W. Simon, Itay Raphael, Kendall M. Johnson, C. Edward Dixon, Vincent Vagni, Keri Janesko-Feldman, Patrick M. Kochanek, H?lya Bayir, Robert S.B. Clark, Mandy J. McGeachy
Publikováno v:
Neurotrauma Reports, Vol 3, Iss 1, Pp 340-351 (2022)
Interleukin-17 (IL-17) is a proinflammatory cytokine primarily secreted in the brain by inflammatory T lymphocytes and glial cells. IL-17+ T-helper (Th17) cells are increased in the ipsilateral hemisphere after experimental traumatic brain injury (TB
Externí odkaz:
https://doaj.org/article/9df196680da748bd88313faa71ecf773
Autor:
Neil K. Munjal, Robert S. B. Clark, Dennis W. Simon, Patrick M. Kochanek, Christopher M. Horvat
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
BackgroundAcute neurological injury is a leading cause of permanent disability and death in the pediatric intensive care unit (PICU). No predictive model has been validated for critically ill children with acute neurological injury.ObjectivesWe hypot
Externí odkaz:
https://doaj.org/article/58bb97b6d4d445e790b37217efd39147
Autor:
Madiha Raees, Shubhada Hooli, Amélie O. von Saint André-von Arnim, Tsegazeab Laeke, Easmon Otupiri, Anthony Fabio, Kristina E. Rudd, Rashmi Kumar, Patrick T. Wilson, Abenezer Tirsit Aklilu, Lisine Tuyisenge, Chunyan Wang, Robert C. Tasker, Derek C. Angus, Patrick M. Kochanek, Ericka L. Fink, Tigist Bacha
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
PurposeTraumatic brain injury (TBI) is a leading cause of morbidity and mortality in low- and middle-income countries (LMICs). Hospital care practices of pediatric TBI patients in LMICs are unknown. Our objective was to report on hospital management
Externí odkaz:
https://doaj.org/article/9f07b355f141403d95d3f931d1f37a0b
Autor:
Stefania Mondello, Viktor Sandner, Mona Goli, Endre Czeiter, Krisztina Amrein, Patrick M. Kochanek, Sakshi Gautam, Byeong Gwan Cho, Ryan Morgan, Ali Nehme, Giacomo Fiumara, Ali H. Eid, Chloe Barsa, Muhammad Ali Haidar, Andras Buki, Firas H. Kobeissy, Yehia Mechref
Publikováno v:
EClinicalMedicine, Vol 50, Iss , Pp 101494- (2022)
Summary: Background: Glycans play essential functional roles in the nervous system and their pathobiological relevance has become increasingly recognized in numerous brain disorders, but not fully explored in traumatic brain injury (TBI). We investig
Externí odkaz:
https://doaj.org/article/0728102a99474dfbbc49395e624e36e7