Zobrazeno 1 - 10
of 84
pro vyhledávání: '"P M, Kerwin"'
Publikováno v:
Molecules, Vol 29, Iss 18, p 4457 (2024)
The dynamic landscape of non-canonical DNA G-quadruplex (G4) folding into G-triplex intermediates has led to the study of G-triplex structures and their ability to serve as peroxidase-mimetic DNAzymes. Here we report the formation, stability, and cat
Externí odkaz:
https://doaj.org/article/27fb7559d52543dbb9b0e46e66769955
Autor:
Claus F. Vogelmeier, Paul W. Jones, Edward M. Kerwin, Isabelle H. Boucot, François Maltais, Lee Tombs, Chris Compton, David A. Lipson, Leif H. Bjermer
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background In patients with chronic obstructive pulmonary disease (COPD), the relationship between short-term bronchodilator reversibility and longer-term response to bronchodilators is unclear. Here, we investigated whether the efficacy of
Externí odkaz:
https://doaj.org/article/497f80b3e99047ddab4f46fa6574eff0
Autor:
F. Maltais, I. P. Naya, C. F. Vogelmeier, I. H. Boucot, P. W. Jones, L. Bjermer, L. Tombs, C. Compton, D. A. Lipson, E. M. Kerwin
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background Short-acting β2-agonist (SABA) bronchodilators help alleviate symptoms in chronic obstructive pulmonary disease (COPD) and may be a useful marker of symptom severity. This analysis investigated whether SABA use impacts treatment
Externí odkaz:
https://doaj.org/article/99e7710a1bbd4fefbaecd5c24df2ee4f
Autor:
Clara M. Kerwin, Anne E. Getz
Publikováno v:
Otolaryngology Case Reports, Vol 21, Iss , Pp 100379- (2021)
Background: Nasal-type NK/T-cell lymphoma is a rare but deadly form of non-Hodgkin's lymphoma that initially presents with local symptoms including erythema, swelling, and epistaxis. Due to misdiagnosis and improper treatment with antibiotics, this t
Externí odkaz:
https://doaj.org/article/207fa4f476b548cfbb22ff9f9f6cda35
Autor:
François Maltais, Leif Bjermer, Edward M. Kerwin, Paul W. Jones, Michael L. Watkins, Lee Tombs, Ian P. Naya, Isabelle H. Boucot, David A. Lipson, Chris Compton, Mitra Vahdati-Bolouri, Claus F. Vogelmeier
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-15 (2019)
Abstract Background Prospective evidence is lacking regarding incremental benefits of long-acting dual- versus mono-bronchodilation in improving symptoms and preventing short-term disease worsening/treatment failure in low exacerbation risk patients
Externí odkaz:
https://doaj.org/article/4397ec211a684a41994894718e1f28f9
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background Long-term use of inhaled corticosteroids (ICSs) has been associated with increased risk of bone and ocular comorbidities. We evaluated the effects of the triple fixed-dose combination budesonide/glycopyrrolate/formoterol fumarate
Externí odkaz:
https://doaj.org/article/8824f280ddfb4bae890046d22fc067f7
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract There is increasing focus on understanding the nature of chronic obstructive pulmonary disease (COPD) during the earlier stages. Mild COPD (Global Initiative for Chronic Obstructive Lung Disease [GOLD] stage 1 or the now-withdrawn GOLD stage
Externí odkaz:
https://doaj.org/article/872508be2b0a43eba03b4bc667348614
Autor:
Claus F. Vogelmeier, Edward M. Kerwin, Leif H. Bjermer, Lee Tombs, Paul W. Jones, Isabelle H. Boucot, Ian P. Naya, David A. Lipson, Chris Compton, Neil Barnes, François Maltais
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 14 (2020)
Rationale: Symptom relief is a key treatment goal in patients with chronic obstructive pulmonary disease (COPD). However, there are limited data available on the response to bronchodilator therapy in patients at low risk of exacerbations with differe
Externí odkaz:
https://doaj.org/article/864c880f44ca4df1a9f0961dff369d9a
Autor:
Edward M Kerwin, Isabelle H Boucot, Claus F Vogelmeier, Francois Maltais, Ian P Naya, Lee Tombs, Paul W Jones, David A Lipson, Tom Keeley, Leif Bjermer
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 14 (2020)
Background: In chronic obstructive pulmonary disease (COPD), both the time needed for patients to gain symptom improvement with long-acting bronchodilator therapy and whether an early response is predictive of a sustained response is unknown. This st
Externí odkaz:
https://doaj.org/article/2846b6af6f334253a8cde4194fb58760
Autor:
Zachary T. Schwartz, Peter D. Theisen, Olaf T. Bjornstal, Mary Rodebaugh, Mauricio A. Jemal, Dallas Lee, Spencer D. Shelton, Zhenze Zhao, Liqin Du, Sean M. Kerwin
Publikováno v:
Molecules, Vol 27, Iss 6, p 1792 (2022)
Plant polyphenols, such as the African potato (Hypoxis hemerocallidea)-derived bis-catechol rooperol, can display promising anticancer activity yet suffer from rapid metabolism. Embarking upon a program to systematically examine potentially more meta
Externí odkaz:
https://doaj.org/article/0dac3729323944b5992822309ee2d393