Výsledky vyhledávání - "P M, Iamanushkin"

[Preclinical study of safety of the new pharmacological substance AV0012 to treat hepatitis C]

Autor: A V, Ivashchenko, P M, Iamanushkin, O D, Mit'kin, E V, Ezhova, O M, Korzinov, N A, Shevkun, R N, Karapetian, V V, Bychko, A A, Ivashchenko, V Z, Agrba, B A, Lapin, S V, Orlov, I É, Kuznetsov

Publikováno v: Eksperimental'naia i klinicheskaia farmakologiia. 77(12)

Pharmacological safety of a new type of HCV inhibitor, AV0012, was studied including acute, subchronic and chronic toxicity in mice, rats and monkeys. Genotoxicity was assessed using the Ames test and the chromosomal aberrations assay in the bone mar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::88c7b5d647832b8fd86d6c612609638c
https://pubmed.ncbi.nlm.nih.gov/25739191

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[Antiviral activity in vitro and pharmacokinetics of HCV entry inhibitor AVR560]

Autor: A V, Ivashchenko, P M, Iamanushkin, O D, Mit'kin, E V, Ezhova, O M, Korzinov, E A, Bulanova, A G, Koriakova, P V, Vyshemirskaia, V V, Bychko, A A, Ivashchenko

Publikováno v: Eksperimental'naia i klinicheskaia farmakologiia. 77(10)

Several novel compounds were found to be potent inhibitors of the HCV (JFH-1 isolate) infection in vitro. Human serum did not significantly reduce antiviral activity of the lead compound, AVR560 (4-fold). The immunohistochemistry studies with the Huh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c40297c81961976f6e1c9cc1bc0a8e21
https://pubmed.ncbi.nlm.nih.gov/25518527

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[Preclinical study of AV0012 early stage inhibitor of hepatitis C virus infection: I. In vitro ADME and pharmacokinetics]

Autor: A V, Ivashchenko, P M, Iamanushkin, O D, Mit'kin, E V, Ezhova, O M, Korzinov, N A, Shevkun, A G, Koriakova, R N, Karapetian, V V, Bychko, A A, Ivashchenko, V Z, Agrba, B A, Lapin, S V, Orlov

Publikováno v: Eksperimental'naia i klinicheskaia farmakologiia. 77(4)

In vitro immunohistochemical investigations on the human hepatoma cell line (Huh7) infected with hepatitis C virus (HCV) strain JFH-1 showed that AV0012 compound blocks the early stages of viral infection. AV0012 also blocked viral infection spread i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f29b1a9a6f0951f98c0ee0a50cf7892b
https://pubmed.ncbi.nlm.nih.gov/25076758

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[Preclinical study of the new anti-influenza drug candidate AV0038 (ethyl 2-(dimethylaminomethyl)-5-hydroxy-1-methyl-6-(pyridin-3-yl)-1H-indole-3-carboxylate)]

Autor: A V, Ivashchenko, P M, Iamanushkin, O D, Mit'kin, O M, Korzinov, N A, Shevkun, R N, Karapetian, A A, Ivashchenko

Publikováno v: Eksperimental'naia i klinicheskaia farmakologiia. 77(5)

In the framework of preclinical testing of AV0038, ethyl 2-(dimethylaminomethyl)-5-hydroxy-1-methyl-6-(pyridin-3-yl)-1H-indole-3-carboxylate, which showed high efficiency in the prevention and treatment of influenza A/Aichi/2/69 (H3N2) in mice, we ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::597a2ee9b91d8bd9afdef0b89413ec4b
https://pubmed.ncbi.nlm.nih.gov/25033568

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