Zobrazeno 1 - 10
of 37
pro vyhledávání: '"P M, Howley"'
Autor:
David B. Chou, Brooke A. Furlong, Ryan R. Posey, Christos Kyprianou, Lucy R. O’Sullivan, Rhiannon David, Suzanne J. Randle, Urszula M. Polanska, Jon Travers, Jelena Urosevic, John N. Hutchinson, Jianwei Che, Anna M. Howley, Robert P. Hasserjian, Rachelle Prantil-Baun, Donald E. Ingber
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Patients treated with Aurora kinase inhibitors experience dose-limiting neutropenia while other cytopenias are rare. Here, Chou et al. show that this cell-type specific side effect is partly explained by loss of drug efflux pump expression during neu
Externí odkaz:
https://doaj.org/article/30b138eaa22049aea33459bc0a7f87f2
Autor:
Mary T. Burkey, Robert A. Managan, Nicholas A. Gentile, Megan Bruck Syal, Kirsten M. Howley, Joseph V. Wasem
Publikováno v:
The Planetary Science Journal, Vol 4, Iss 12, p 243 (2023)
In the event of a potentially catastrophic asteroid impact, with sufficient warning time, deploying a nuclear device remains a powerful option for planetary defense if a kinetic impactor or other means of deflection proves insufficient. Predicting th
Externí odkaz:
https://doaj.org/article/3597d7395d6c4b7dba63740f26a363f3
Autor:
Jessamine E Hazlewood, Troy Dumenil, Thuy T Le, Andrii Slonchak, Stephen H Kazakoff, Ann-Marie Patch, Lesley-Ann Gray, Paul M Howley, Liang Liu, John D Hayball, Kexin Yan, Daniel J Rawle, Natalie A Prow, Andreas Suhrbier
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009215 (2021)
Poxvirus systems have been extensively used as vaccine vectors. Herein a RNA-Seq analysis of intramuscular injection sites provided detailed insights into host innate immune responses, as well as expression of vector and recombinant immunogen genes,
Externí odkaz:
https://doaj.org/article/51873aa015164c15b3f0332db477b26b
Publikováno v:
Expert Review of Vaccines, Vol 17, Iss 10, Pp 925-934 (2018)
Introduction: With the increasing number of vaccines and vaccine-preventable diseases, the pressure to generate multi-valent and multi-pathogen vaccines grows. Combining individual established vaccines to generate single-shot formulations represents
Externí odkaz:
https://doaj.org/article/2dbf7c5aaf93487fa930b4b90a8ff06c
Autor:
Natalie A. Prow, Liang Liu, Eri Nakayama, Tamara H. Cooper, Kexin Yan, Preethi Eldi, Jessamine E. Hazlewood, Bing Tang, Thuy T. Le, Yin Xiang Setoh, Alexander A Khromykh, Jody Hobson-Peters, Kerrilyn R. Diener, Paul M. Howley, John D. Hayball, Andreas Suhrbier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Zika and chikungunya virus are co-circulating in many regions and currently there is no approved vaccine for either virus. Here, the authors engineer one vaccinia virus based vaccine for both, Zika and chikungunya, and show protection from infection
Externí odkaz:
https://doaj.org/article/fb33c22d0fd945c1b4999adae6928f2c
Autor:
Liang Liu, Tamara Cooper, Preethi Eldi, Pablo Garcia-Valtanen, Kerrilyn R. Diener, Paul M. Howley, John D. Hayball
Publikováno v:
BioTechniques, Vol 62, Iss 4, Pp 183-187 (2017)
Recombinant vaccinia viruses (rVACVs) are promising antigen-delivery systems for vaccine development that are also useful as research tools. Two common methods for selection during construction of rVACV clones are (i) co-insertion of drug resistance
Externí odkaz:
https://doaj.org/article/b3404c6f21114b35a0e331a2f981ba5f
Autor:
Wilson Nguyen, Eri Nakayama, Kexin Yan, Bing Tang, Thuy T. Le, Liang Liu, Tamara H. Cooper, John D. Hayball, Helen M. Faddy, David Warrilow, Richard J. N. Allcock, Jody Hobson-Peters, Roy A. Hall, Daniel J. Rawle, Viviana P. Lutzky, Paul Young, Nidia M. Oliveira, Gunter Hartel, Paul M. Howley, Natalie A. Prow, Andreas Suhrbier
Publikováno v:
Vaccines, Vol 8, Iss 2, p 209 (2020)
Chikungunya virus (CHIKV), Ross River virus (RRV), o’nyong nyong virus (ONNV), Mayaro virus (MAYV) and Getah virus (GETV) represent arthritogenic alphaviruses belonging to the Semliki Forest virus antigenic complex. Antibodies raised against one of
Externí odkaz:
https://doaj.org/article/ab91253b909a4655ac9a7f198f2a6b40
Autor:
Jingwei Cheng, Donglim Esther Park, Christian Berrios, Elizabeth A White, Reety Arora, Rosa Yoon, Timothy Branigan, Tengfei Xiao, Thomas Westerling, Alexander Federation, Rhamy Zeid, Benjamin Strober, Selene K Swanson, Laurence Florens, James E Bradner, Myles Brown, Peter M Howley, Megha Padi, Michael P Washburn, James A DeCaprio
Publikováno v:
PLoS Pathogens, Vol 13, Iss 10, p e1006668 (2017)
Merkel cell carcinoma (MCC) frequently contains integrated copies of Merkel cell polyomavirus DNA that express a truncated form of Large T antigen (LT) and an intact Small T antigen (ST). While LT binds RB and inactivates its tumor suppressor functio
Externí odkaz:
https://doaj.org/article/09d9ce0281074c5285116f21831c3c3c
Publikováno v:
Viruses, Vol 6, Iss 10, Pp 3787-3808 (2014)
Vaccinia virus (VACV) has achieved unprecedented success as a live viral vaccine for smallpox which mitigated eradication of the disease. Vaccinia virus has a complex virion morphology and recent advances have been made to answer some of the key outs
Externí odkaz:
https://doaj.org/article/8016ecaabbe34456a2955a6e7733d0b5
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
ABSTRACT The major transformation activity of the high-risk human papillomaviruses (HPV) is associated with the E7 oncoprotein. The interaction of HPV E7 with retinoblastoma family proteins is important for several E7 activities; however, this intera
Externí odkaz:
https://doaj.org/article/48b42be47f234822b503ae440d22e202