Zobrazeno 1 - 10
of 15
pro vyhledávání: '"P M, Hastie"'
Autor:
Shailendra Kumar Verma, Fernanda Ana-Sosa-Batiz, Julia Timis, Norazizah Shafee, Erin Maule, Paolla Beatriz Almeida Pinto, Chris Conner, Kristen M. Valentine, Dale O. Cowley, Robyn Miller, Annie Elong Ngono, Linda Tran, Krithik Varghese, Rúbens Prince Dos Santos Alves, Kathryn M. Hastie, Erica Ollmann Saphire, David R. Webb, Kurt Jarnagin, Kenneth Kim, Sujan Shresta
Publikováno v:
EBioMedicine, Vol 108, Iss , Pp 105361- (2024)
Summary: Background: Mouse models that recapitulate key features of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection are important tools for understanding complex interactions between host genetics, immune responses, and SARS-Co
Externí odkaz:
https://doaj.org/article/04220e5ef32e4419879fefba16782ce9
Autor:
Adam J. Ronk, Nicole M. Lloyd, Min Zhang, Caroline Atyeo, Hailee R. Perrett, Chad E. Mire, Kathryn M. Hastie, Rogier W. Sanders, Philip J. M. Brouwer, Erica Olmann Saphire, Andrew B. Ward, Thomas G. Ksiazek, Juan Carlos Alvarez Moreno, Harshwardhan M. Thaker, Galit Alter, Sunny Himansu, Andrea Carfi, Alexander Bukreyev
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Lassa virus is a member of the Arenaviridae family, which causes human infections ranging from asymptomatic to severe hemorrhagic disease with a high case fatality rate. We have designed and generated lipid nanoparticle encapsulated, modifie
Externí odkaz:
https://doaj.org/article/4afd193033d54672afc7fc5b00f7b333
Autor:
Laura Bricio-Moreno, Juliana Barreto de Albuquerque, Jake M. Neary, Thao Nguyen, Lucy F. Kuhn, YeePui Yeung, Kathryn M. Hastie, Sara Landeras-Bueno, Eduardo Olmedillas, Chitra Hariharan, Anusha Nathan, Matthew A. Getz, Alton C. Gayton, Ashok Khatri, Gaurav D. Gaiha, Erica Ollmann Saphire, Andrew D. Luster, James J. Moon
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Understanding adaptive immunity against SARS-CoV-2 is a major requisite for the development of effective vaccines and treatments for COVID-19. CD4+ T cells play an integral role in this process primarily by generating antiviral cytokines and providin
Externí odkaz:
https://doaj.org/article/c24e9f2a0035458781607e8fc3058230
Autor:
Xiaoying Yu, Kathryn M. Hastie, Carl W. Davis, Ruben Diaz Avalos, Dewight Williams, Diptiben Parekh, Sean Hui, Colin Mann, Chitra Hariharan, Ayato Takada, Rafi Ahmed, Erica Ollmann Saphire
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113366- (2023)
Summary: Monoclonal antibodies against the Ebola virus (EBOV) surface glycoprotein are effective treatments for EBOV disease. Antibodies targeting the EBOV glycoprotein (GP) head epitope have potent neutralization and Fc effector function activity an
Externí odkaz:
https://doaj.org/article/469c37f692e8430a9c9fd7e5c88c3a20
Autor:
Kathryn M. Hastie, Xiaoying Yu, Fernanda Ana-Sosa-Batiz, Dawid S. Zyla, Stephanie S. Harkins, Chitra Hariharan, Hal Wasserman, Michelle A. Zandonatti, Robyn Miller, Erin Maule, Kenneth Kim, Kristen M. Valentine, Sujan Shresta, Erica Ollmann Saphire
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112421- (2023)
Summary: Therapeutic antibodies are an important tool in the arsenal against coronavirus infection. However, most antibodies developed early in the pandemic have lost most or all efficacy against newly emergent strains of severe acute respiratory syn
Externí odkaz:
https://doaj.org/article/05a63022e4b143f984c77e5eae90c9db
Autor:
Heather M. Callaway, Kathryn M. Hastie, Sharon L. Schendel, Haoyang Li, Xiaoying Yu, Jeremy Shek, Tierra Buck, Sean Hui, Dan Bedinger, Camille Troup, S. Moses Dennison, Kan Li, Michael D. Alpert, Charles C. Bailey, Sharon Benzeno, Jody L. Bonnevier, Jin-Qiu Chen, Charm Chen, Hyeseon Cho, Peter D. Crompton, Vincent Dussupt, Kevin C. Entzminger, Yassine Ezzyat, Jonathan K. Fleming, Nick Geukens, Amy E. Gilbert, Yongjun Guan, Xiaojian Han, Christopher J. Harvey, Julia M. Hatler, Bryan Howie, Chao Hu, Ailong Huang, Maya Imbrechts, Aishun Jin, Nik Kamachi, Gladys Keitany, Mark Klinger, Jay K. Kolls, Shelly J. Krebs, Tingting Li, Feiyan Luo, Toshiaki Maruyama, Michael A. Meehl, Letzibeth Mendez-Rivera, Andrea Musa, C.J. Okumura, Benjamin E.R. Rubin, Aaron K. Sato, Meiying Shen, Anirudh Singh, Shuyi Song, Joshua Tan, Jeffrey M. Trimarchi, Dhruvkumar P. Upadhyay, Yingming Wang, Lei Yu, Tom Z. Yuan, Erik Yusko, Bjoern Peters, Georgia Tomaras, Erica Ollmann Saphire
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 112014- (2023)
Summary: The SARS-CoV-2 Omicron variant of concern (VoC) and its sublineages contain 31–36 mutations in spike and escape neutralization by most therapeutic antibodies. In a pseudovirus neutralization assay, 66 of the nearly 400 candidate therapeuti
Externí odkaz:
https://doaj.org/article/61e61f138daa45d1ba9a2edb473cf0bc
Autor:
Tierra K. Buck, Adrian S. Enriquez, Sharon L. Schendel, Michelle A. Zandonatti, Stephanie S. Harkins, Haoyang Li, Alex Moon-Walker, James E. Robinson, Luis M. Branco, Robert F. Garry, Erica Ollmann Saphire, Kathryn M. Hastie
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Lassa virus (LASV) is the causative agent of the deadly Lassa fever (LF). Seven distinct LASV lineages circulate through western Africa, among which lineage I (LI), the first to be identified, is particularly resistant to antibody neutraliza
Externí odkaz:
https://doaj.org/article/14afc02eed1544d890e770847136ffa2
Autor:
Anthea C. Lindquist, Roxanne M. Hastie, Richard J. Hiscock, Natasha L. Pritchard, Susan P. Walker, Stephen Tong
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-8 (2021)
Abstract Background Post-term gestation beyond 41+6 completed weeks of gestation is known to be associated with a sharp increase in the risk of stillbirth and perinatal mortality. However, the risk of common adverse outcomes related to labour, such a
Externí odkaz:
https://doaj.org/article/9b9950e5c74f4483bcc1581178fa0e45
Autor:
James E. Robinson, Kathryn M. Hastie, Robert W. Cross, Rachael E. Yenni, Deborah H. Elliott, Julie A. Rouelle, Chandrika B. Kannadka, Ashley A. Smira, Courtney E. Garry, Benjamin T. Bradley, Haini Yu, Jeffrey G. Shaffer, Matt L. Boisen, Jessica N. Hartnett, Michelle A. Zandonatti, Megan M. Rowland, Megan L. Heinrich, Luis Martínez-Sobrido, Benson Cheng, Juan C. de la Torre, Kristian G. Andersen, Augustine Goba, Mambu Momoh, Mohamed Fullah, Michael Gbakie, Lansana Kanneh, Veronica J. Koroma, Richard Fonnie, Simbirie C. Jalloh, Brima Kargbo, Mohamed A. Vandi, Momoh Gbetuwa, Odia Ikponmwosa, Danny A. Asogun, Peter O. Okokhere, Onikepe A. Follarin, John S. Schieffelin, Kelly R. Pitts, Joan B. Geisbert, Peter C. Kulakoski, Russell B. Wilson, Christian T. Happi, Pardis C. Sabeti, Sahr M. Gevao, S. Humarr Khan, Donald S. Grant, Thomas W. Geisbert, Erica Ollmann Saphire, Luis M. Branco, Robert F. Garry
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Lassa virus can cause haemorrhagic fever for which no specific treatment currently exists. Here the authors have cloned 113 monoclonal antibodies from the survivors of Lassa infection and show that the majority of neutralizing antibodies target a com
Externí odkaz:
https://doaj.org/article/d40aae7302c442638a735c72e28f07c6
Autor:
Fatima Amanat, James Duehr, Lisa Oestereich, Kathryn M. Hastie, Erica Ollmann Saphire, Florian Krammer
Publikováno v:
mSphere, Vol 3, Iss 3 (2018)
ABSTRACT Arenaviruses pose a major public health threat and cause numerous infections in humans each year. Although most viruses belonging to this family do not cause disease in humans, some arenaviruses, such as Lassa virus and Machupo virus, are th
Externí odkaz:
https://doaj.org/article/a6c6a386b5444076b86f295ba579bb72