Zobrazeno 1 - 10
of 62
pro vyhledávání: '"P M, Guyre"'
Publikováno v:
Dose-Response, Vol 9 (2011)
Natural and synthetic glucocorticoids (GCs) have been used for decades to suppress inflammation. In this paper, we re-examine the role of the endogenous GC, cortisol, as a primary homeostatic regulator of the human inflammatory response to injury. Ou
Externí odkaz:
https://doaj.org/article/408553c256e4479691043a09d705cfb5
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5539 (2009)
BACKGROUND:Monocytes and macrophages are key innate immune effector cells that produce cytokines and chemokines upon activation. We and others have shown that 17beta-estradiol (E2) has a direct role in the modulation of monocyte and macrophage immune
Externí odkaz:
https://doaj.org/article/d98a6708757141af8f48de968016d5f7
Publikováno v:
Acta Anaesthesiologica Scandinavica. 48:799-813
During the first half of the 20th century, physiologists were interested in the adrenal glands primarily because adrenalectomized animals failed to survive even mild degrees of systemic stress. It eventually became clear that hormones secreted by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8021872c6dff48b2cb9685b9264f61c
https://doi.org/10.1111/j.1399-6576.2004.00434.x
https://doi.org/10.1111/j.1399-6576.2004.00434.x
Autor:
N A Fanger, D Voigtlaender, C Liu, S Swink, K Wardwell, J Fisher, R F Graziano, L C Pfefferkorn, P M Guyre
Publikováno v:
The Journal of Immunology. 158:3090-3098
The mechanisms responsible for efficient sequestration of Ag by cells of the dendritic cell (DC) lineage remain incompletely characterized. One pathway, internalization of Ag-IgG complexes via CD32 (the type II IgG FcR, Fc gamma RII) enhances Ag pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4fd28e9346b9b2756eb0f525490fcd5
https://doi.org/10.4049/jimmunol.158.7.3090
https://doi.org/10.4049/jimmunol.158.7.3090
Publikováno v:
The Journal of Immunology. 157:541-548
Three classes of Fc receptors for IgG, Fc gamma RI (CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16), are expressed on blood leukocytes. Although Fc gamma R are important phagocytic receptors on phagocytes, most reports suggest that dendritic cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::425c0aca193697f3e02520b04f343ccf
https://doi.org/10.4049/jimmunol.157.2.541
https://doi.org/10.4049/jimmunol.157.2.541
Autor:
R F Graziano, P R Tempest, P White, T Keler, Y Deo, H Ghebremariam, K Coleman, L C Pfefferkorn, M W Fanger, P M Guyre
Publikováno v:
The Journal of Immunology. 155:4996-5002
The murine mAb 22 (M22) binds to the human high affinity receptor for the Fc portion of IgG (Fc gamma RI). This mAb recognizes an epitope on Fc gamma RI that is distinct from the natural ligand (Fc) binding site, and, therefore, can bind to Fc gamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3bded9d3abf02a926d02e0e5e4b3f9d
https://doi.org/10.4049/jimmunol.155.10.4996
https://doi.org/10.4049/jimmunol.155.10.4996
Publikováno v:
Methods in molecular medicine. 64
Fc receptors specific for IgG (FcγR) potentiate the immune response by facilitating the interaction between myeloid cells and antibody-coated targets (1-3). Monocyte and neutrophil FcyR engagement can lead to the induction of lytic-type mechanisms a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04d4c5c39f768f054bec16767bdcc286
https://pubmed.ncbi.nlm.nih.gov/21374276
https://pubmed.ncbi.nlm.nih.gov/21374276
Publikováno v:
The Journal of Immunology. 151:6429-6439
Human PBL express one or more of the three classes of Fc receptors for IgG (Fc gamma receptors, I, II, and III). Each type of Fc gamma receptor has a characteristic binding pattern for isotypes of human and mouse IgG. Large granular lymphocyte/NK cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f38b2743382b3161aeb5a6b5d2d9988
https://doi.org/10.4049/jimmunol.151.11.6429
https://doi.org/10.4049/jimmunol.151.11.6429
Publikováno v:
The Journal of Immunology. 151:1482-1490
Polymorphonuclear neutrophils (PMN) have long been thought to be short-lived, terminally differentiated cells incapable of synthesizing significant levels of protein, with their primary function being phagocytosis and the release of cytotoxic compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3b09627137b6c3d177d66a6051d288c
https://doi.org/10.4049/jimmunol.151.3.1482
https://doi.org/10.4049/jimmunol.151.3.1482
Autor:
P M Guyre, Dan L. Longo, C H Ewel, J W Smith nd, William C. Kopp, C Main, W G Alvord, Ronald G. Steis, W J Urba
Publikováno v:
Journal of Immunotherapy. 13:181-190
Interferon-gamma (IFN-gamma) is a potent monocyte/macrophage activating agent that in animal models exhibits a bell-shaped dose-response curve of immunomodulatory activity and antitumor efficacy. Previous clinical trials of IFN-gamma conducted at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3968a14e5c6d08f9324931e75829bf
https://doi.org/10.1097/00002371-199304000-00005
https://doi.org/10.1097/00002371-199304000-00005