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Akademický článek

ESCHR: a hyperparameter-randomized ensemble approach for robust clustering across diverse datasets

Publikováno v: Genome Biology, Vol 25, Iss 1, Pp 1-27 (2024)

Abstract Clustering is widely used for single-cell analysis, but current methods are limited in accuracy, robustness, ease of use, and interpretability. To address these limitations, we developed an ensemble clustering method that outperforms other m

Externí odkaz: https://doaj.org/article/55fb6f1d7752459ab5aa75c041d0273d

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Akademický článek

A high-throughput 3D X-ray histology facility for biomedical research and preclinical applications [version 2; peer review: 3 approved, 1 approved with reservations]

Autor: Philip J. Basford, Orestis L. Katsamenis, Richard P. Boardman, Stephanie K. Robinson, Peter M. Lackie, Elena Konstantinopoulou, J. Arjuna Ratnayaka, Anton Page, Gareth J. Thomas, Patricia M. Goggin, Ian Sinclair, Simon J. Cox, Philipp Schneider

Publikováno v: Wellcome Open Research, Vol 8 (2023)

Background The University of Southampton, in collaboration with the University Hospital Southampton (UHS) NHS Foundation Trust and industrial partners, has been at the forefront of developing three-dimensional (3D) imaging workflows using X-ray micro

Externí odkaz: https://doaj.org/article/b0eca1b24de04d559f74a9f42a48df65

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Akademický článek

A high-throughput 3D X-ray histology facility for biomedical research and preclinical applications [version 1; peer review: 2 approved]

Publikováno v: Wellcome Open Research, Vol 8 (2023)

Background: The University of Southampton, in collaboration with the University Hospital Southampton (UHS) NHS Foundation Trust and industrial partners, has been at the forefront of developing three-dimensional (3D) imaging workflows using X-ray micr

Externí odkaz: https://doaj.org/article/19ceba3d86a1405fb292bd21883dfb12

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Akademický článek

High-resolution genome-wide functional dissection of transcriptional regulatory regions and nucleotides in human

Autor: Xinchen Wang, Liang He, Sarah M. Goggin, Alham Saadat, Li Wang, Nasa Sinnott-Armstrong, Melina Claussnitzer, Manolis Kellis

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Millions of enhancers are predicted, but their validation remains challenging. Here, the authors report genome-wide enhancer function quantification and high-resolution dissection for millions of accessible DNA fragments, revealing driver nucleotides

Externí odkaz: https://doaj.org/article/b840b6fe3d734ff1922a52f00577dac1

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Akademický článek

Culture of primary ciliary dyskinesia epithelial cells at air-liquid interface can alter ciliary phenotype but remains a robust and informative diagnostic aid.

Autor: Robert A Hirst, Claire L Jackson, Janice L Coles, Gwyneth Williams, Andrew Rutman, Patricia M Goggin, Elizabeth C Adam, Anthony Page, Hazel J Evans, Peter M Lackie, Christopher O'Callaghan, Jane S Lucas

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e89675 (2014)

The diagnosis of primary ciliary dyskinesia (PCD) requires the analysis of ciliary function and ultrastructure. Diagnosis can be complicated by secondary effects on cilia such as damage during sampling, local inflammation or recent infection. To diff

Externí odkaz: https://doaj.org/article/f40fd44fc77f4bfc8bf5409717d71003

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Cancer cachexia

Autor: J N, Gordon, S R, Green, P M, Goggin

Publikováno v: QJM: An International Journal of Medicine. 98:779-788

Cancer cachexia is a severe debilitating disorder for which there are currently few therapeutic options. It is driven by the release of pro-inflammatory cytokines and cachectic factors by both host and tumour. Over the past few years, basic science a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344b7a72621a703b798cb876d5f8c05d
https://doi.org/10.1093/qjmed/hci127

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Diagnosis

Autor: W. G. Zhukhovitski, L. I. Aruin, A. S. Ilchenko, V. S. Gorodinskaya, K. Meyer-Rosberg, S. Gustavsson, J. A. Maeland, P. M. Kleveland, A. I. Kvam, E. M. Witteman, P. Bloembergen, R. W. de Koning, M. Alcalde, A. Lanche, P. Carpintero, R. Garcia, P. Sanchez, J. M. Pajares, T. C. K. Tham, N. McLaughlin, D. F. Hughes, M. Ferguson, J. J. Crosbie, M. Madden, S. Namnyak, F. A. O’Connor, G. Gosciniak, T. Matysiak-Budnik, E. Poniewierka, A. Przondo-Mordarska, R. Monno, M. Quarto, E. Ierardi, M. Chironna, P. Cafforio, M. Margiotta, A. Francavilla, I. Yamamoto, Y. Fukuda, Y. Tonokatsu, S. Takami, T. Mizuta, T. Hayashi, T. Tamura, S. Hori, T. Shimoyama, K. Juutinen, C. Granberg, V. M. Häivä, O. P. Lehtonen, H. Kujari, A. Mansikka, E. Martín, J. C. Sanz, T. Alarcón, L. Cardenoso, M. López-Brea, Frank C. Powell, M. A. Daw, Chris Duguid, H. Goossens, Y. Glupczynski, A. Burette, C. Deprez, C. Van den Borre, J. P. Butzler, R. A. Veenendaa, A. S. Peña, I. Kuiper, W. Van Duijn, C. B. H. W. Lamers, E. De Koster, F. Fannes, P. Denis, E. Baise, A. Van Roosbroeck, J. F. Nyst, M. Deltenre, E. O. Adeyemi, M. Al-Homsi, C. S. Goodwin, B. Demers, M. Karmali, P. Sherman, S. M. Pender, M. G. Courtney, H. Holloway, T. B. Sexton, J. F. Fielding, E. N. Mendes, D. M. M. Queiroz, G. A. Rocha, S. B. Moura, M. I. Barbosa, S. M. Carvalhaes, M. L. P. Freitas, M. A. Mendall, P. M. Goggin, N. Molineaux, J. Levi, T. Harding, J. H. Maneno, C. Corbishley, C. Finlayson, S. Badue, T. C. Northfield, Veltzhe-Schliehenlr Moldrzyyk, H. Vogt, K. Trautman, M. Hampel, T. Hausmann, K. F. Gratz, A. Kelber, B. Soudan, S. Wagner, H. Hundeshagen, L. Jurgos, M. Druguet, C. Pommier, M. Rousseau, P. Courpron, J. L. Brazier, J. Marks, G. Gopal Rao, I. Cobden, R. Johri, S. John, A. D. Rodgers, Magbri Awad, Altaf Naqvi, C. F. McCarthy, Jette E. Kristiansen, L. P. Andersen, T. Justesen, E. F. Hvidberg, A. S. Tahar, J. Reid, P. Boothmann, C. G. Gemmell, F. D. Lee, R. D. Sturrock, I. Russell, P. Tessaro, R. Schiavon, M. G. Contini, M. Rugge, M. Guido, S. Glorioso, F. Turatello, R. Naccarato, M. Kist, B. Eschweiler, H. K. Koch, D. Dzierzanowska, E. Vogtt, U. Wojda, J. Muszynski, W. Laszewicz, W. Skawinski

Publikováno v: Irish Journal of Medical Science. 161:73-82

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b67e33d7539f14b7bf914ac6eb3a62e
https://doi.org/10.1007/bf02942893

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Epidemiology

Autor: B. Fixa, O. Komárková, K. Krejsek, J. Bures, Z. Nozicka, W. Giorcelli, M. Rodi, G. Camisasca, R. G. Martinotti, M. A. Mendall, P. M. Goggin, Nicola Molineaux, Joanne Levy, T. Toosy, D. Strachan, T. C. Northfield, T. Vorobjova, V. Vassiljev, K. Kisand, T. Wadström, R. Uibo, R. B. Zotz, S. G. Xu, G. von Recklinghausen, P. Meusers, H. Goebell, K. H Rhee, H. S. Youn, S. K. Paik, W. K. Lee, M. J. Cho, C. K. Park, Yuyuan Li, Pinjin Hu, Guoguang Du, Zhijin Wong, Stuart L. Hazell, Hazel M. Mitchell, J. D. de Korwin, P. Remot, Ph Hartemann, A. Catelle, M. C. Conroy, J. Schmitt, M. Stolte, E. Wellens, B. Bethke, M. Ritter, H. Eidt, S. Veldhuyzen van Zanten, L. Best, G. Bezanson, T. Marrie, E. Poniewierka, G. Gosciniak, T. Matysiak-Budnik, M. Quatrini, F. Boni, A. R. Baldassarri, A. De Vecchi, C. Castelnovo, E. Viganò, L. Tenconi, P. A. Bianchi, A. Carlucci, G. Ferrini, I Bianco, G. Larcinese, A. Di Sciascio, G. F. Fly, T. Hauge, J. Persson, L. G. V. Coelho, M. M. Teixeira, M. C. F. Passos, C. B. Givisiez, C. M. F. R. Santos, C. J. S. Rodrigues, Y. Chausson, L. P. Castro, Hannu Hyvärinen, Kari Seppälä, Eero Kivilaakso, Timo Kosunen, Martin Gormse, A. Pilotto, F. Vianello, D. Tornaboni, P. Dotto, G. Battaglia, F. Binda, F. Di Mario, P. M. Donisi, M. Pasini, M. E. Benve-nuti, V. Stracca-Pansa, M. Pasquino, H. Jablonowski, H. Szelényi, K. J. Hengels, G. Strohmeyer, N. Banatvala, K. Mayo, F. Megraud, R. Jennings, J. J. Deeks, R. A. Feldman, G. Bulighin, A. Ederie, S. Pilati, G. Franzin, G. Zamboni, M. Maran, R. Musola, A. Tobin, R. C. Hackman, G. B. McDonald, N. Fatela, J. Melo Cristino, L. Monteiro, F. Ramalho, A. Saragoça, M. J. Salgado, M. Cameiro de Moura, S. Pretolani, G. Gasbarrini, F. Bonvicini, M. Baraldini, E. Tonelli, M. R. A. Gatto, G. C. Ghironzi, F. M égraud, S. Bouchard, W. Lubcvzumiska-Kowalska, Z. Knapik, J. Meenan, M. Goggins, C. Shahi, P. W. N. Keeling, C. Keane, D. G. Weir, D. Vaira, M. Miglioli, P. Mulè, J. Holten, M. Menegati, G. Biasco, M. Vergura, A. Nannetti, L. Barbara, A. Boschini, M. Begnini, M. Menegatti, C. Ghira, A. D’Errico, D. G. Evans, M. A. Asnicar, D. J. Evans, D. Y. Graham, C. H. Lee, M. Coschieri, T. Fosse, M. C. St. Paul, J. R. Michiels, J. P. Delmont, J. L. Péroux, C. Pradier, P. Rampai, P. Pazzi, A. Merighi, S. Gamberini, R. Scarliarini, R. Bicochi, M. Libanore, G. Bisi, S. Gulllini

Publikováno v: Irish Journal of Medical Science. 161:59-68

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27a7b3ec8ed64c6314731f580205ea10
https://doi.org/10.1007/bf02942891

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Thalidomide and its derivatives: emerging from the wilderness

Autor: J N Gordon, P M Goggin

Publikováno v: Postgraduate medical journal. 79(929)

Forty years on from its worldwide withdrawal, thalidomide is currently undergoing a remarkable renaissance as a novel and powerful immunomodulatory agent. Over the last decade it has been found to be active in a wide variety of inflammatory and malig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f061fbf6e0b35d5180dc914178b3f5f0
https://pubmed.ncbi.nlm.nih.gov/12697909

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Relation of Helicobacter pylori infection and coronary heart disease

Autor: Michael A. Mendall, J. Levy, T. Toosy, N. Molineaux, Timothy C. Northfield, David P. Strachan, P. M. Goggin, A. J. Camm

Publikováno v: Heart. 71:437-439

BACKGROUND--There is evidence suggesting that early life experience may influence adult risk of coronary heart disease (CHD). Chronic bacterial infections have been associated with CHD. OBJECTIVE--To determine whether Helicobacter pylori, a childhood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4dd812d4abb48be083b6a0ad45642c
https://doi.org/10.1136/hrt.71.5.437

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