A chromosome-level genome for the nudibranch gastropod Berghia stephanieae helps parse clade-specific gene expression in novel and conserved phenotypes

Autor: Jessica A. Goodheart, Robin A. Rio, Neville F. Taraporevala, Rose A. Fiorenza, Seth R. Barnes, Kevin Morrill, Mark Allan C. Jacob, Carl Whitesel, Park Masterson, Grant O. Batzel, Hereroa T. Johnston, M. Desmond Ramirez, Paul S. Katz, Deirdre C. Lyons

Publikováno v: BMC Biology, Vol 22, Iss 1, Pp 1-21 (2024)

Abstract Background How novel phenotypes originate from conserved genes, processes, and tissues remains a major question in biology. Research that sets out to answer this question often focuses on the conserved genes and processes involved, an approa

Externí odkaz: https://doaj.org/article/f375f31b80ac46ca8abf0fdfde41d0ae

Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression

Autor: Sara Larivière, Jessica Royer, Raúl Rodríguez-Cruces, Casey Paquola, Maria Eugenia Caligiuri, Antonio Gambardella, Luis Concha, Simon S. Keller, Fernando Cendes, Clarissa L. Yasuda, Leonardo Bonilha, Ezequiel Gleichgerrcht, Niels K. Focke, Martin Domin, Felix von Podewills, Soenke Langner, Christian Rummel, Roland Wiest, Pascal Martin, Raviteja Kotikalapudi, Terence J. O’Brien, Benjamin Sinclair, Lucy Vivash, Patricia M. Desmond, Elaine Lui, Anna Elisabetta Vaudano, Stefano Meletti, Manuela Tondelli, Saud Alhusaini, Colin P. Doherty, Gianpiero L. Cavalleri, Norman Delanty, Reetta Kälviäinen, Graeme D. Jackson, Magdalena Kowalczyk, Mario Mascalchi, Mira Semmelroch, Rhys H. Thomas, Hamid Soltanian-Zadeh, Esmaeil Davoodi-Bojd, Junsong Zhang, Gavin P. Winston, Aoife Griffin, Aditi Singh, Vijay K. Tiwari, Barbara A. K. Kreilkamp, Matteo Lenge, Renzo Guerrini, Khalid Hamandi, Sonya Foley, Theodor Rüber, Bernd Weber, Chantal Depondt, Julie Absil, Sarah J. A. Carr, Eugenio Abela, Mark P. Richardson, Orrin Devinsky, Mariasavina Severino, Pasquale Striano, Domenico Tortora, Erik Kaestner, Sean N. Hatton, Sjoerd B. Vos, Lorenzo Caciagli, John S. Duncan, Christopher D. Whelan, Paul M. Thompson, Sanjay M. Sisodiya, Andrea Bernasconi, Angelo Labate, Carrie R. McDonald, Neda Bernasconi, Boris C. Bernhardt

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Epilepsy is a brain network disorder with associated genetic risk factors. Here, the authors show that spatial patterns of transcriptomic vulnerability co-vary with structural brain network alterations in focal and generalized epilepsy.

Externí odkaz: https://doaj.org/article/42a2adc39a114a5faf720bcffa41fabd

Accelerated clearing and molecular labeling of biological tissues using magnetohydrodynamic force

Autor: Joseph Dwyer, M. Desmond Ramirez, Paul S. Katz, Rolf O. Karlstrom, Joseph Bergan

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Abstract Techniques used to clear biological tissue for fluorescence microscopy are essential to connect anatomical principles at levels ranging from subcellular to the whole animal. Here we report a simple and straightforward approach to efficiently

Externí odkaz: https://doaj.org/article/c1b507e37c8446c3b4426afebbbe9637

Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: A worldwide ENIGMA-Epilepsy study

Autor: Ezequiel Gleichgerrcht, Brent C. Munsell, Saud Alhusaini, Marina K.M. Alvim, Núria Bargalló, Benjamin Bender, Andrea Bernasconi, Neda Bernasconi, Boris Bernhardt, Karen Blackmon, Maria Eugenia Caligiuri, Fernando Cendes, Luis Concha, Patricia M. Desmond, Orrin Devinsky, Colin P. Doherty, Martin Domin, John S. Duncan, Niels K. Focke, Antonio Gambardella, Bo Gong, Renzo Guerrini, Sean N. Hatton, Reetta Kälviäinen, Simon S. Keller, Peter Kochunov, Raviteja Kotikalapudi, Barbara A.K. Kreilkamp, Angelo Labate, Soenke Langner, Sara Larivière, Matteo Lenge, Elaine Lui, Pascal Martin, Mario Mascalchi, Stefano Meletti, Terence J. O'Brien, Heath R. Pardoe, Jose C. Pariente, Jun Xian Rao, Mark P. Richardson, Raúl Rodríguez-Cruces, Theodor Rüber, Ben Sinclair, Hamid Soltanian-Zadeh, Dan J. Stein, Pasquale Striano, Peter N. Taylor, Rhys H. Thomas, Anna Elisabetta Vaudano, Lucy Vivash, Felix von Podewills, Sjoerd B. Vos, Bernd Weber, Yi Yao, Clarissa Lin Yasuda, Junsong Zhang, Paul M. Thompson, Sanjay M. Sisodiya, Carrie R. McDonald, Leonardo Bonilha, Andre Altmann, Chantal Depondt, Marian Galovic, Sophia I. Thomopoulos, Roland Wiest

Publikováno v: NeuroImage: Clinical, Vol 31, Iss , Pp 102765- (2021)

Artificial intelligence has recently gained popularity across different medical fields to aid in the detection of diseases based on pathology samples or medical imaging findings. Brain magnetic resonance imaging (MRI) is a key assessment tool for pat

Externí odkaz: https://doaj.org/article/04e5634905854974bc8546298c41b38c

Baseline White Matter Is Associated With Physical Fitness Change in Preclinical Alzheimer’s Disease

Autor: Vijay K. Venkatraman, Christopher E. Steward, Kay L. Cox, Kathryn A. Ellis, Pramit M. Phal, Matthew J. Sharman, Victor L. Villemagne, Michelle M. Y. Lai, Elizabeth V. Cyarto, David Ames, Cassandra Szoeke, Christopher C. Rowe, Colin L. Masters, Nicola T. Lautenschlager, Patricia M. Desmond

Publikováno v: Frontiers in Aging Neuroscience, Vol 12 (2020)

White matter (WM) microstructure is a sensitive marker to distinguish individuals at risk of Alzheimer’s disease. The association of objective physical fitness (PF) measures and WM microstructure has not been explored and mixed results reported wit

Externí odkaz: https://doaj.org/article/28381c6e46f7411d8f4d224867ed4a9b