Zobrazeno 1 - 10
of 41
pro vyhledávání: '"P M, Coussens"'
Autor:
Marina Baretti, Ludmila Danilova, Jennifer N. Durham, Courtney B. Betts, Leslie Cope, Dimitrios N. Sidiropoulos, Joseph A. Tandurella, Soren Charmsaz, Nicole Gross, Alexei Hernandez, Won Jin Ho, Chris Thoburn, Rosalind Walker, James Leatherman, Sarah Mitchell, Brian Christmas, Ali Saeed, Daria A. Gaykalova, Srinivasan Yegnasubramanian, Elana J. Fertig, Lisa M. Coussens, Mark Yarchoan, Elizabeth Jaffee, Nilofer S. Azad
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Pancreatic ductal adenocarcinoma (PDA) is characterized by low cytotoxic lymphocytes, abundant immune-suppressive cells, and resistance to immune checkpoint inhibitors (ICI). Preclinical PDA models showed the HDAC inhibitor entinostat reduce
Externí odkaz:
https://doaj.org/article/da588e36b348473cb1c930008d58747b
Autor:
Sushil Kumar, Dhanir Tailor, Arpit Dheeraj, Wenqi Li, Kirsten Stefan, Jee Min Lee, Dylan Nelson, Bailey F. Keefe, Pepper Schedin, Shivaani Kummar, Lisa M. Coussens, Sanjay V. Malhotra
Publikováno v:
Cell Reports Medicine, Vol 5, Iss 9, Pp 101698- (2024)
Summary: Tumor-associated macrophages (TAMs) and other myelomonocytic cells are implicated in regulating responsiveness to immunotherapies, including immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis. We have developed an ex vivo high
Externí odkaz:
https://doaj.org/article/cfaf32627f2d4969978c0e42493daa35
Autor:
Zinab O. Doha, Xiaoyan Wang, Nicholas L. Calistri, Jennifer Eng, Colin J. Daniel, Luke Ternes, Eun Na Kim, Carl Pelz, Michael Munks, Courtney Betts, Sunjong Kwon, Elmar Bucher, Xi Li, Trent Waugh, Zuzana Tatarova, Dylan Blumberg, Aaron Ko, Nell Kirchberger, Jennifer A. Pietenpol, Melinda E. Sanders, Ellen M. Langer, Mu-Shui Dai, Gordon Mills, Koei Chin, Young Hwan Chang, Lisa M. Coussens, Joe W. Gray, Laura M. Heiser, Rosalie C. Sears
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Triple-negative breast cancer (TNBC) patients have a poor prognosis and few treatment options. Mouse models of TNBC are important for development of new therapies, however, few mouse models represent the complexity of TNBC. Here, we develop
Externí odkaz:
https://doaj.org/article/2f5efa1be7d149bcb492c236e0e02ed5
Autor:
Burcu Gurun, Wesley Horton, Dhaarini Murugan, Biqing Zhu, Patrick Leyshock, Sushil Kumar, Katelyn T. Byrne, Robert H. Vonderheide, Adam A. Margolin, Motomi Mori, Paul T. Spellman, Lisa M. Coussens, Terence P. Speed
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-13 (2023)
Abstract T cell receptor repertoires can be profiled using next generation sequencing (NGS) to measure and monitor adaptive dynamical changes in response to disease and other perturbations. Genomic DNA-based bulk sequencing is cost-effective but nece
Externí odkaz:
https://doaj.org/article/f072a81ae5e44edd9681ef3c1accf20e
Autor:
Eun Na Kim, Phyllis Zixuan Chen, Dario Bressan, Monika Tripathi, Ahmad Miremadi, Massimiliano di Pietro, Lisa M. Coussens, Gregory J. Hannon, Rebecca C. Fitzgerald, Lizhe Zhuang, Young Hwan Chang
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 10, Pp 100595- (2023)
Summary: Imaging mass cytometry (IMC) is a powerful technique capable of detecting over 30 markers on a single slide. It has been increasingly used for single-cell-based spatial phenotyping in a wide range of samples. However, it only acquires a rect
Externí odkaz:
https://doaj.org/article/310d138d2c38433c976e5760fa2c40f5
Autor:
Joseph J. Sepe, PhD, Ryan T. Gardner, PhD, Matthew R. Blake, BS, Deja M. Brooks, BS, Melanie A. Staffenson, BS, Courtney B. Betts, PhD, Sam Sivagnanam, MS, William Larson, BS, Sushil Kumar, PhD, Richard G. Bayles, PhD, Haihong Jin, PhD, Michael S. Cohen, PhD, Lisa M. Coussens, PhD, Beth A. Habecker, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 7, Iss 9, Pp 915-930 (2022)
Summary: Myocardial infarction (MI) triggers an inflammatory response that transitions from pro-inflammatory to reparative over time. Restoring sympathetic nerves in the heart after MI prevents arrhythmias. This study investigated if reinnervation al
Externí odkaz:
https://doaj.org/article/e9c3ebef13134e50a3813ff599fa7eea
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-14 (2022)
Abstract There is increasing evidence that the spatial organization of cells within the tumor-immune microenvironment (TiME) of solid tumors influences survival and response to therapy in numerous cancer types. Here, we report results and demonstrate
Externí odkaz:
https://doaj.org/article/f688fa4c36d04692b5dff26739d4cdf0
Autor:
Marilyne Labrie, Allen Li, Allison Creason, Courtney Betts, Jamie Keck, Brett Johnson, Shamilene Sivagnanam, Christopher Boniface, Hongli Ma, Aurora Blucher, Young Hwan Chang, Koei Chin, Jacqueline Vuky, Alexander R. Guimaraes, Molly Downey, Jeong Youn Lim, Lina Gao, Kiara Siex, Swapnil Parmar, Annette Kolodzie, Paul T. Spellman, Jeremy Goecks, Lisa M. Coussens, Christopher L. Corless, Raymond Bergan, Joe W. Gray, Gordon B. Mills, Zahi I. Mitri
Publikováno v:
npj Precision Oncology, Vol 5, Iss 1, Pp 1-11 (2021)
Abstract In a pilot study, we evaluated the feasibility of real-time deep analysis of serial tumor samples from triple negative breast cancer patients to identify mechanisms of resistance and treatment opportunities as they emerge under therapeutic s
Externí odkaz:
https://doaj.org/article/6f75a6bf3b4848219df5905c62072ab5
Autor:
Gerardo Gatti, Courtney Betts, Darío Rocha, Maribel Nicola, Verónica Grupe, Cecilia Ditada, Nicolas G. Nuñez, Emiliano Roselli, Paula Araya, Jeremías Dutto, Lucia Boffelli, Elmer Fernández, Lisa M. Coussens, Mariana Maccioni
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-15 (2021)
Abstract Background Characterization of breast cancer (BC) through the determination of conventional markers such as ER, PR, HER2, and Ki67 has been useful as a predictive and therapeutic tool. Also, assessment of tumor-infiltrating lymphocytes has b
Externí odkaz:
https://doaj.org/article/2407c5f713e8417d9bcfd3f90edf443d
Autor:
Srinand Sundaram, Eun Na Kim, Georgina M. Jones, Shamilene Sivagnanam, Monika Tripathi, Ahmad Miremadi, Massimiliano Di Pietro, Lisa M. Coussens, Rebecca C. Fitzgerald, Young Hwan Chang, Lizhe Zhuang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Esophageal adenocarcinoma (EAC) develops from a chronic inflammatory environment across four stages: intestinal metaplasia, known as Barrett’s esophagus, low- and high-grade dysplasia, and adenocarcinoma. Although the genomic characteristics of thi
Externí odkaz:
https://doaj.org/article/63bf9b8c972a49af8cca8899f3d05383