Zobrazeno 1 - 10
of 724
pro vyhledávání: '"P LEYSSEN"'
Autor:
Li-Hsin Li, Winston Chiu, Yun-An Huang, Madina Rasulova, Thomas Vercruysse, Hendrik Jan Thibaut, Sebastiaan ter Horst, Joana Rocha-Pereira, Greet Vanhoof, Doortje Borrenberghs, Olivia Goethals, Suzanne J. F. Kaptein, Pieter Leyssen, Johan Neyts, Kai Dallmeier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract To curb viral epidemics and pandemics, antiviral drugs are needed with activity against entire genera or families of viruses. Here, we develop a cell-based multiplex antiviral assay for high-throughput screening against multiple viruses at o
Externí odkaz:
https://doaj.org/article/883693f5cd604c2dad6b91f11a0839d3
Autor:
Irene Wanjiru Kiarie, Gyula Hoffka, Manon Laporte, Pieter Leyssen, Johan Neyts, József Tőzsér, Mohamed Mahdi
Publikováno v:
Viruses, Vol 16, Iss 10, p 1607 (2024)
Retroviruses perpetuate their survival by incorporating a copy of their genome into the host cell, a critical step catalyzed by the virally encoded integrase. The viral capsid plays an important role during the viral life cycle, including nuclear imp
Externí odkaz:
https://doaj.org/article/57bb4a1180f94884a606280b15fe17ae
Publikováno v:
Diversity, Vol 16, Iss 8, p 487 (2024)
Softwater ponds with Lobelia dortmanna (EU habitat type 3110) represent the rarest aquatic habitat in Belgium. As in many other European countries, its unfavourable conservation status necessitates restoration according to the EU Habitats Directive,
Externí odkaz:
https://doaj.org/article/9e5c3b5041f441b084fe738ea1837b6f
Akademický článek
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Autor:
Sirle Saul, Marwah Karim, Luca Ghita, Pei-Tzu Huang, Winston Chiu, Verónica Durán, Chieh-Wen Lo, Sathish Kumar, Nishank Bhalla, Pieter Leyssen, Farhang Alem, Niloufar A. Boghdeh, Do H.N. Tran, Courtney A. Cohen, Jacquelyn A. Brown, Kathleen E. Huie, Courtney Tindle, Mamdouh Sibai, Chengjin Ye, Ahmed Magdy Khalil, Kevin Chiem, Luis Martinez-Sobrido, John M. Dye, Benjamin A. Pinsky, Pradipta Ghosh, Soumita Das, David E. Solow-Cordero, Jing Jin, John P. Wikswo, Dirk Jochmans, Johan Neyts, Steven De Jonghe, Aarthi Narayanan, Shirit Einav
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Targeting host factors exploited by multiple viruses could offer broad-spectrum solutions for pandemic preparedness. Seventeen candidates targeting diverse functions emerged in a screen of 4,413 compounds for SARS-CoV-2 inhibitors. We demonstrated th
Externí odkaz:
https://doaj.org/article/9cc9d935abdc4025aa6c81ab75a6d932
Autor:
Viki Bockstal, Maarten Leyssen, Dirk Heerwegh, Bart Spiessens, Cynthia Robinson, Jeroen N. Stoop, Ramon Roozendaal, Thierry Van Effelterre, Auguste Gaddah, Griet A. Van Roey, Laura Solforosi, Roland Zahn, Benoit Callendret, Jenny Hendriks, Kerstin Luhn, Macaya Douoguih, Hanneke Schuitemaker, Johan Van Hoof
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-8 (2022)
Abstract Without clinical efficacy data, vaccine protective effect may be extrapolated from animals to humans using an immunologic marker that correlates with protection in animals. This immunobridging approach was used for the two-dose Ebola vaccine
Externí odkaz:
https://doaj.org/article/62001c2a26ba43fdbeac3ea1080907ee
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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Autor:
Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen, Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon, Pieter Leyssen
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-11 (2022)
Measurement(s) Cytopathic Effect Technology Type(s) confocal fluorescence microscopy Factor Type(s) Cellular toxicity Sample Characteristic - Organism Chlorocebus sabaeus Sample Characteristic - Environment continuant Sample Characteristic - Location
Externí odkaz:
https://doaj.org/article/d090bc5600084cffb8b7e56ad1250b1a
Autor:
Etienne Karita, Julien Nyombayire, Rosine Ingabire, Amelia Mazzei, Tyronza Sharkey, Jeannine Mukamuyango, Susan Allen, Amanda Tichacek, Rachel Parker, Frances Priddy, Felix Sayinzoga, Sabin Nsanzimana, Cynthia Robinson, Michael Katwere, Dickson Anumendem, Maarten Leyssen, Malinda Schaefer, Kristin M. Wall
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-23 (2022)
Abstract Background Risks to mother and fetus following Ebola virus infection are very high. Evaluation of safety and immunogenicity of non-replicating Ebola vaccine candidates is a priority for use in pregnant women. This is the protocol for a rando
Externí odkaz:
https://doaj.org/article/38e58ac027044ca4bd84f54a7a41ccf5
Autor:
Viki Bockstal, Auguste Gaddah, Neil Goldstein, Georgi Shukarev, Stephan Bart, Kerstin Luhn, Cynthia Robinson, Dickson Anumendem, Maarten Leyssen, Macaya Douoguih
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract Two phase 3 clinical studies were conducted in the USA to bridge across different Ad26.ZEBOV manufacturing processes and sites, and to evaluate the immunogenicity of different dose levels of Ad26.ZEBOV and MVA-BN-Filo. Study 1 evaluated the
Externí odkaz:
https://doaj.org/article/7c2795f7e19c4f3e9ae22a1cfba61a16