Výsledky vyhledávání - "P L Woodhead"

Akademický článek

Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition

Autor: James J. Beaudoin, Kyunghee Yang, Jeffry Adiwidjaja, Guncha Taneja, Paul B. Watkins, Scott Q. Siler, Brett A. Howell, Jeffrey L. Woodhead

Publikováno v: Frontiers in Pharmacology, Vol 13 (2023)

Inhibition of the canalicular phospholipid floppase multidrug resistance protein 3 (MDR3) has been implicated in cholestatic drug-induced liver injury (DILI), which is clinically characterized by disrupted bile flow and damage to the biliary epitheli

Externí odkaz: https://doaj.org/article/854fa12f4fac4c6c81044b54a6766df4

Zobrazit plný text záznamu

Akademický článek

Experience Disclosing Mental Health Conditions Among College Students from Different Ethnic Backgrounds

Autor: Shilpa R. Hampole, Steven H. S. Nguyen, Erin L. Woodhead

Publikováno v: Building Healthy Academic Communities Journal, Vol 3, Iss 2, Pp 66-72 (2019)

Aim: The current study compared disclosure of mental health problems to staff, faculty, and peers among college students from different ethnic backgrounds. Background: Although there are differences in mental health stigma between college students fr

Externí odkaz: https://doaj.org/article/325118a666034c66b67aae40fb3d608f

Zobrazit plný text záznamu

Akademický článek

Exploring BSEP Inhibition-Mediated Toxicity with a Mechanistic Model of Drug-Induced Liver Injury

Autor: Jeffrey L Woodhead, Kyunghee eYang, Scott Q Siler, Paul Brent Watkins, Kim L.R. Brouwer, Hugh A Barton, Brett A Howell

Publikováno v: Frontiers in Pharmacology, Vol 5 (2014)

Inhibition of the bile salt export pump (BSEP) has been linked to incidence of drug-induced liver injury (DILI), presumably by the accumulation of toxic bile acids in the liver. We have previously constructed and validated a model of bile acid dispos

Externí odkaz: https://doaj.org/article/64259af463dc478a95f0ad84590ccafa

Zobrazit plný text záznamu

Akademický článek

Modeling drug- and chemical- induced hepatotoxicity with systems biology approaches

Autor: Sudin eBhattacharya, Lisl K.M. Shoda, Qiang eZhang, Courtney eWoods, Brett A. Howell, Scott Q. Siler, Jeffrey L. Woodhead, Yuching eYang, Patrick eMcMullen, Paul B. Watkins, Melvin E. Andersen

Publikováno v: Frontiers in Physiology, Vol 3 (2012)

We provide an overview of computational systems biology approaches as applied to the study of chemical- and drug-induced toxicity. The concept of ‘toxicity pathways’ is described in the context of the 2007 US National Academies of Science report,

Externí odkaz: https://doaj.org/article/578b7eda103f4784bce6ab2aa88a0665

Zobrazit plný text záznamu