Zobrazeno 1 - 10
of 24
pro vyhledávání: '"P L Hermonat"'
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104596 (2014)
Adeno-associated virus (AAV) (type 2) is a popular human gene therapy vector with a long active transgene expression period and no reported vector-induced adverse reactions. Yet the basic molecular biology of this virus has not been fully addressed.
Externí odkaz:
https://doaj.org/article/9f834d1bc0a444058320b9c9bf91aff2
Autor:
Hongqing Zhu, Maohua Cao, Leonardo Mirandola, Jose A Figueroa, Everardo Cobos, Maurizio Chiriva-Internati, Paul L Hermonat
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94665 (2014)
The development of gene therapy vectors for treating diseases of the cardiovascular system continues at a steady pace. Moreover, in the field of gene therapy the utility of "disease-specific promoters" has strong appeal. Many therapeutic genes, inclu
Externí odkaz:
https://doaj.org/article/06028fdcc81a4e369620e54f40b928f0
Publikováno v:
International Journal of Vascular Medicine, Vol 2012 (2012)
Both IL-10 and STAT3 are in the same signal transduction pathway, with IL-10-bound IL10 receptor (R) acting through STAT3 for anti-inflammatory effect. To investigate possible therapeutic synergism, we delivered both full-length wild-type human (h) S
Externí odkaz:
https://doaj.org/article/7e31e0529abe471e9eb31f846211d811
Publikováno v:
Virus Genes. 12:47-52
Adeno-associated virus (AAV) is a human parvovirus that in laboratory and animal models has the ability to suppress the oncogenic phenotype of a variety of viruses and cellular derived oncogenes. The inhibitory effects of AAV have been mapped to its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9774ec2099af745b7293ad671fb9ed4c
https://doi.org/10.1007/bf00370000
https://doi.org/10.1007/bf00370000
Autor:
Dazhi Zhang, Changxuan You, P. L. Hermonat, Min Cong, W. Ping, J. L. Mehta, Hong You, Yong Liu
Publikováno v:
Journal of viral hepatitis. 13(9)
Hepatitis B virus (HBV) has been an increasing problem throughout the world and remains difficult to treat. But immunotherapeutic approaches offer new, effective treatments. Three recombinant adeno-associated virus (AAV) type 2 vectors, carrying one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f59168a2314a57ea457d9362ac175b
https://pubmed.ncbi.nlm.nih.gov/16907847
https://pubmed.ncbi.nlm.nih.gov/16907847
Autor:
Y, Liu, V S, Klimberg, N R, Andrews, C R, Hicks, H, Peng, M, Chiriva-Internati, R, Henry-Tillman, P L, Hermonat
Publikováno v:
Journal of human virology. 4(6)
The major molecular events in the genesis of most breast cancers are unknown. However, human papillomaviruses (HPV) have been reported to be found in a significant portion of breast cancers of women with concomitant cervical intraepithelial neoplasia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::71206f95160b0db29e495ad54a52fce0
https://pubmed.ncbi.nlm.nih.gov/12082399
https://pubmed.ncbi.nlm.nih.gov/12082399
Autor:
M, Chiriva-Internati, F, Grizzi, B, Franceschini, P L, Hermonat, S, Lim, N, Dioguardi, F M, Rodriguez
Publikováno v:
In vitro cellulardevelopmental biology. Animal. 37(10)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01e35cb26e89a658096a1b7eab919344
https://pubmed.ncbi.nlm.nih.gov/11776968
https://pubmed.ncbi.nlm.nih.gov/11776968
Publikováno v:
Journal of human virology. 3(3)
Both human papillomavirus (HPV) and adeno-associated virus (AAV) are common anogenital viruses and likely co-infect the epithelium in vivo. However, whereas HPVs are positively associated with cervical cancer, AAV appears to be negatively associated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c415dc01f0ee694c1fbbbd8cb9349370
https://pubmed.ncbi.nlm.nih.gov/10881991
https://pubmed.ncbi.nlm.nih.gov/10881991
Autor:
P L, Hermonat, A D, Santin, J, De Greve, M, De Rijcke, B M, Bishop, L, Han, M, Mane, N, Kokorina
Publikováno v:
Journal of human virology. 2(6)
Human adeno-associated virus (AAV) is ubiquitous and known to establish latency by chromosomal integration. We have constructed a wild-type plus AAV vector, ins96-0.9Neo, containing the neomycin resistance gene open reading frame (Neo ORF) of 960 bas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33a0ad76c91293b8b870cf95107f9a17
https://pubmed.ncbi.nlm.nih.gov/10774553
https://pubmed.ncbi.nlm.nih.gov/10774553
Publikováno v:
Journal of human virology. 1(7)
It has been well documented by several laboratories that adeno-associated virus (AAV) is able to inhibit HIV-1 replication and gene expression. This effect has been mapped to the AAV-encoded Rep78 protein. However, the mechanism by which Rep78 is abl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::446e75aa18878239fdca3aead20f2368
https://pubmed.ncbi.nlm.nih.gov/10195265
https://pubmed.ncbi.nlm.nih.gov/10195265