Zobrazeno 1 - 10
of 142
pro vyhledávání: '"P L E M, van Lent"'
Autor:
Irene Di Ceglie, Peter L. E. M. van Lent, Edwin J. W. Geven, Marije I. Koenders, Arjen B. Blom, Thomas Vogl, Johannes Roth, Martijn H. J. van den Bosch
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-12 (2021)
Abstract Background Excessive osteoclast activity, which is strongly stimulated by pro-inflammatory mediators, results in bone and cartilage degeneration as central features of many arthritides. Levels of the alarmin S100A8/A9 and interleukin (IL)-1
Externí odkaz:
https://doaj.org/article/007fde91b5b342df9e647aa4c1e5e630
Autor:
Nathalie G. M. Thielen, Margot Neefjes, Elly L. Vitters, Henk M. van Beuningen, Arjen B. Blom, Marije I. Koenders, Peter L. E. M. van Lent, Fons A. J. van de Loo, Esmeralda N. Blaney Davidson, Arjan P. M. van Caam, Peter M. van der Kraan
Publikováno v:
Cells, Vol 11, Iss 7, p 1232 (2022)
During osteoarthritis (OA), hypertrophy-like chondrocytes contribute to the disease process. TGF-β’s signaling pathways can contribute to a hypertrophy(-like) phenotype in chondrocytes, especially at high doses of TGF-β. In this study, we examine
Externí odkaz:
https://doaj.org/article/a631d94a620f4eafa36cfb68ffd19d7e
Autor:
Onno J Arntz, Bartijn C H Pieters, Peter L E M van Lent, Marije I Koenders, Peter M van der Kraan, Fons A J van de Loo
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236508 (2020)
Extracellular vesicles (EVs) are cell membrane-derived phospholipid bilayer nanostructures that contain bioactive proteins, enzymes, lipids and polymers of nucleotides. They play a role in intercellular communication and are present in body fluids. E
Externí odkaz:
https://doaj.org/article/16f57ed371db47b689c9c415c50d4931
Autor:
Julia Vullings, Juliana P. Vago, Claire E. J. Waterborg, Rogier M. Thurlings, Marije I. Koenders, Peter L. E. M. van Lent, Peter M. van der Kraan, Flavio A. Amaral, Fons A. J. van de Loo
Publikováno v:
Journal of Immunology Research, Vol 2020 (2020)
Objective. To investigate the role of TAM receptors in rheumatoid arthritis (RA) by determining synovial tissue TAM receptor expression, synovial fluid levels of soluble TAM receptors, and the relationship between soluble TAM receptors, joint inflamm
Externí odkaz:
https://doaj.org/article/0ff036da414845289704bd57e5c2a89d
Autor:
Irene Di Ceglie, Giuliana Ascone, Niels A. J. Cremers, Annet W. Sloetjes, Birgitte Walgreen, Thomas Vogl, Johannes Roth, J. Sjef Verbeek, Fons A. J. van de Loo, Marije I. Koenders, Peter M. van der Kraan, Arjen B. Blom, Martijn H. J. van den Bosch, Peter L. E. M. van Lent
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-15 (2018)
Abstract Background Osteoclast-mediated bone erosion is a central feature of rheumatoid arthritis (RA). Immune complexes, present in a large percentage of patients, bind to Fcγ receptors (FcγRs), thereby modulating the activity of immune cells. In
Externí odkaz:
https://doaj.org/article/9d7253effde542e1a9c44878e23e232e
Autor:
Nik N. L. Kruisbergen, Irene Di Ceglie, Yvonne van Gemert, Birgitte Walgreen, Monique M. A. Helsen, Annet W. Slöetjes, Marije I. Koenders, Fons A. J. van de Loo, Johannes Roth, Thomas Vogl, Peter M. van der Kraan, Arjen B. Blom, Peter L. E. M. van Lent, Martijn H. J. van den Bosch
Publikováno v:
Antioxidants, Vol 10, Iss 11, p 1660 (2021)
Osteoarthritis (OA) is a destructive disease of the joint with age and obesity being its most important risk factors. Around 50% of OA patients suffer from inflammation of the synovial joint capsule, which is characterized by increased abundance and
Externí odkaz:
https://doaj.org/article/78cf3de17a744173a88dbeea58163c1d
Autor:
Niels A. J. Cremers, Martijn H. J. van den Bosch, Stephanie van Dalen, Irene Di Ceglie, Giuliana Ascone, Fons van de Loo, Marije Koenders, Peter van der Kraan, Annet Sloetjes, Thomas Vogl, Johannes Roth, Edwin J. W. Geven, Arjen B. Blom, Peter L. E. M. van Lent
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-15 (2017)
Abstract Background Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets are described: pro-inflammatory Ly6Chigh and patrolling Ly6Clow monocytes. Alarmins
Externí odkaz:
https://doaj.org/article/000ad2f4ec3f47dc9d28f7482a1ea756
Autor:
Bartijn C. H. Pieters, Alfredo Cappariello, Martijn H. J. van den Bosch, Peter L. E. M. van Lent, Anna Teti, Fons A. J. van de Loo
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Extracellular vesicles are a heterogeneous group of cell-derived membranous structures, which facilitate intercellular communication. Recent studies have highlighted the importance of extracellular vesicles in bone homeostasis, as mediators of crosst
Externí odkaz:
https://doaj.org/article/605f9676c5824d79a8960daa56856dc9
Autor:
Stephanie C. M. van Dalen, Arjen B. Blom, Birgitte Walgreen, Annet W. Slöetjes, Monique M. A. Helsen, Edwin J. W. Geven, Menno ter Huurne, Thomas Vogl, Johannes Roth, Fons A. J. van de Loo, Marije I. Koenders, Louis Casteilla, Peter M. van der Kraan, Martijn H. J. van den Bosch, Peter L. E. M. van Lent
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Background: Injection of adipose-derived mesenchymal stromal cells (ASCs) into murine knee joints after induction of inflammatory collagenase-induced osteoarthritis (CiOA) reduces development of joint pathology. This protection is only achieved when
Externí odkaz:
https://doaj.org/article/6ad2b9a22dd747d49bfb41f920fc06d9
Autor:
Rebecca Rogier, Thomas H A Ederveen, Harm Wopereis, Anita Hartog, Jos Boekhorst, Sacha A F T van Hijum, Jan Knol, Johan Garssen, Birgitte Walgreen, Monique M Helsen, Peter M van der Kraan, Peter L E M van Lent, Fons A J van de Loo, Shahla Abdollahi-Roodsaz, Marije I Koenders
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0227517 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0219366.].
Externí odkaz:
https://doaj.org/article/e8f37efd65e74fe29b0a7b6a14b2ed58