Zobrazeno 1 - 10
of 635
pro vyhledávání: '"P L, Sharpe"'
Autor:
Harris E. Blankenship, Kelsey A. Carter, Kevin D. Pham, Nina T. Cassidy, Andrea N. Markiewicz, Michael I. Thellmann, Amanda L. Sharpe, Willard M. Freeman, Michael J. Beckstead
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Alzheimer’s disease (AD) patients exhibit neuropsychiatric symptoms that extend beyond classical cognitive deficits, suggesting involvement of subcortical areas. Here, we investigated the role of midbrain dopamine (DA) neurons in AD using
Externí odkaz:
https://doaj.org/article/dd82a031eca54bdd80aba860fe826dbc
Autor:
Sam L. Sharpe
Publikováno v:
Journal of Eating Disorders, Vol 12, Iss 1, Pp 1-9 (2024)
Abstract The eating and feeding disorder section of the Diagnostic and Statistical Manual of Mental Disorders 5 Text Revision (DSM-5-TR) is organized by a diagnostic algorithm that limits the contemporaneous assignment of multiple eating disorder dia
Externí odkaz:
https://doaj.org/article/2a3a409605734363a18f265d5297b4c5
Autor:
Rosiel Elwyn, Marissa Adams, Sam L. Sharpe, Scout Silverstein, Andrea LaMarre, James Downs, C. Blair Burnette
Publikováno v:
Journal of Eating Disorders, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Eating disorders (EDs) are complex, multifaceted conditions that significantly impact quality-of-life, often co-occur with multiple medical and psychiatric diagnoses, and are associated with a high risk of medical sequelae and mortality. For
Externí odkaz:
https://doaj.org/article/09ebe8f9fae941e4a66e84ce9fa8b200
Autor:
Shelby L. Sharpe, Susan A. Elwood
Publikováno v:
Social Sciences, Vol 13, Iss 10, p 522 (2024)
As global populations age, there is an urgent need to address the unique learning requirements of older adults in the context of e-learning. This study builds upon prior work to investigate the connections between older adults’ cognitive profiles,
Externí odkaz:
https://doaj.org/article/a064ae3cc26c47668abf977799e07041
Publikováno v:
Journal of Eating Disorders, Vol 11, Iss 1, Pp 1-9 (2023)
Abstract Informed by our lived experiences with eating disorders, our work providing direct support to communities underserved by existing healthcare structures, and our commitment to social justice, we are deeply troubled by several aspects of the p
Externí odkaz:
https://doaj.org/article/ab1047ec09bd436b9f421e147e26da30
Autor:
Collyn M. Kellogg, Kevin Pham, Sunghwan Ko, Jillian E.J. Cox, Adeline H. Machalinski, Michael B. Stout, Amanda L. Sharpe, Michael J. Beckstead, Ana J. Chucair-Elliott, Sarah R. Ocañas, Willard M. Freeman
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108413- (2023)
Summary: Temporally controlling Cre recombination through tamoxifen (Tam) induction has many advantages for biomedical research. Most studies report early post-natal/juvenile (12 m.o.). While anecdotally reported as problematic, there are no publishe
Externí odkaz:
https://doaj.org/article/efa2f29c8faf4f80b3c9fffa0d593cbf
Autor:
Alexis L. Sharpe, Joan Reibman, Beno W. Oppenheimer, Roberta M. Goldring, Mengling Liu, Yongzhao Shao, Isaac Bohart, Benjamin Kwok, Tatiana Weinstein, Doreen Addrizzo-Harris, Daniel H. Sterman, Kenneth I. Berger
Publikováno v:
ERJ Open Research, Vol 9, Iss 3 (2023)
Background Isolated small airway abnormalities may be demonstrable at rest in patients with normal spirometry; however, the relationship of these abnormalities to exertional symptoms remains uncertain. This study uses an augmented cardiopulmonary exe
Externí odkaz:
https://doaj.org/article/090bb09f13084a8494a53bbdf276cdf1
Autor:
Ryan J. H. West, Joanne L. Sharpe, André Voelzmann, Anna L. Munro, Ines Hahn, Richard A. Baines, Stuart Pickering-Brown
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract A large intronic hexanucleotide repeat expansion (GGGGCC) within the C9orf72 (C9orf72-SMCR8 Complex Subunit) locus is the most prevalent genetic cause of both Frontotemporal Dementia (FTD) and Motor Neuron Disease (MND). In patients this exp
Externí odkaz:
https://doaj.org/article/4e9a52c5a5ea4a479ca7cd7829ad0e49
Publikováno v:
Frontiers in Ecology and Evolution, Vol 10 (2022)
Anthropogenic climate change is increasing the frequency and intensity of heat waves, thereby threatening biodiversity, particularly in hot, arid regions. Although free-ranging endotherms can use behavioral thermoregulation to contend with heat, it r
Externí odkaz:
https://doaj.org/article/105ae99870b341c395631ab09acde2c2
Publikováno v:
Cells, Vol 12, Iss 5, p 677 (2023)
Cancer metastasis, the process by which tumour cells spread throughout the body and form secondary tumours at distant sites, is the leading cause of cancer-related deaths. The metastatic cascade is a highly complex process encompassing initial dissem
Externí odkaz:
https://doaj.org/article/ba6eeb2e1ee94f53b914a672e190602e