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The 6-minute walk test (6MWT) is not intended to document oxygen (O2) desaturation during exertion but is often used for this purpose. Because of this, it only has modest reproducibility in determining the need for ambulatory O2 therapy in patients w

Externí odkaz: https://doaj.org/article/af4dafcd7e5a40d8a55ccd59a8fe4812

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Competitive irreversible inhibition of dopamine uptake by 6-hydroxydopamine

Autor: D E, Decker, J S, Althaus, S E, Buxser, P F, VonVoigtlander, P L, Ruppel

Publikováno v: Research communications in chemical pathology and pharmacology. 79(2)

We examined the effects of 6-hydroxydopamine (6-OHDA) treatment on the human neuroblastoma cell line SK-N-SH-SY5Y (SY5Y) and the rat pheochromocytoma cell line, PC12. Structural and metabolic integrity was tested by measuring the ability of cells to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f6c6e6174420e96efd0d687d200af65
https://pubmed.ncbi.nlm.nih.gov/8451541

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Intrinsic activity determinations at the dopamine D2 guanine nucleotide-binding protein-coupled receptor: utilization of receptor state binding affinities

Autor: R A, Lahti, L M, Figur, M F, Piercey, P L, Ruppel, D L, Evans

Publikováno v: Molecular pharmacology. 42(3)

Guanine nucleotide-binding protein-coupled receptors have been shown to exist in both a high affinity agonist (HiAg) and a low affinity agonist (LowAg) state. The formation of the HiAg state is promoted by agonists, and the formation of this state of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b11fb5061dbbc82abf3d3102af19453
https://pubmed.ncbi.nlm.nih.gov/1357542

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Myeloid differentiated HL-60 cells display specific leukotriene B4 binding sites

Autor: R R, Gorman, P L, Ruppel, C W, Benjamin

Publikováno v: Advances in prostaglandin, thromboxane, and leukotriene research. 16

Exposure of HL-60 cells for 6 days to a combination of 1.25% (v/v) dimethyl sulfoxide (DMSO) and 10 microM dexamethasone (DEX) induces myeloid differentiation which results in a cell with many of the characteristics of a mature granulocyte. At 4 degr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2168049934e01a21ca2cce70643f8f65
https://pubmed.ncbi.nlm.nih.gov/3028094

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Evidence for leukotriene B4 receptors in human neutrophils

Autor: R R, Gorman, P L, Ruppel, A H, Lin

Publikováno v: Advances in prostaglandin, thromboxane, and leukotriene research. 15

[3H]LTB4 binds concentration-dependently to intact human PMNs. The binding is saturable, reaches equilibrium in 10 min at 4 degrees C, and is readily reversible. Mathematical modeling analysis reveals biphasic binding of [3H]LTB4, indicating two disc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7bafdbd59cee9f434b074cce9963f89e
https://pubmed.ncbi.nlm.nih.gov/3004151

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