Zobrazeno 1 - 10
of 24
pro vyhledávání: '"P L, Mellon"'
Autor:
Brooke M. Van Loh, Alexandra M. Yaw, Joseph A. Breuer, Brooke Jackson, Duong Nguyen, Krystal Jang, Fabiola Ramos, Emily V. Ho, Laura J. Cui, Dominique L. M. Gillette, Lorenzo F. Sempere, Michael R. Gorman, Karen J. Tonsfeldt, Pamela L. Mellon, Hanne M. Hoffmann
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundThe suprachiasmatic nucleus (SCN) within the hypothalamus is a key brain structure required to relay light information to the body and synchronize cell and tissue level rhythms and hormone release. Specific subpopulations of SCN neurons, de
Externí odkaz:
https://doaj.org/article/fe803c0e29b2466a93a3c13294295d69
Autor:
Jessica Cassin, Maria I. Stamou, Kimberly W. Keefe, Kaitlin E. Sung, Celine C. Bojo, Karen J. Tonsfeldt, Rebecca A. Rojas, Vanessa Ferreira Lopes, Lacey Plummer, Kathryn B. Salnikov, David L. Keefe Jr., Metin Ozata, Myron Genel, Neoklis A. Georgopoulos, Janet E. Hall, William F. Crowley Jr., Stephanie B. Seminara, Pamela L. Mellon, Ravikumar Balasubramanian
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
Pathogenic SRY-box transcription factor 2 (SOX2) variants typically cause severe ocular defects within a SOX2 disorder spectrum that includes hypogonadotropic hypogonadism. We examined exome-sequencing data from a large, well-phenotyped cohort of pat
Externí odkaz:
https://doaj.org/article/767994d5a65b43fab45a677b83b0584b
Autor:
Karen J. Tonsfeldt, Laura J. Cui, Jinkwon Lee, Thijs J. Walbeek, Liza E. Brusman, Ye Jin, Michihiro Mieda, Michael R. Gorman, Pamela L. Mellon
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Disruptions to the circadian system alter reproductive capacity, particularly in females. Mice lacking the core circadian clock gene, Bmal1, are infertile and have evidence of neuroendocrine disruption including the absence of the preovulatory lutein
Externí odkaz:
https://doaj.org/article/ccc8699a188a4143890678faf2da2f60
Autor:
Jason D. Meadows, Joseph A. Breuer, Shanna N. Lavalle, Michael R. Hirschenberger, Meera M. Patel, Duong Nguyen, Alyssa Kim, Jessica Cassin, Michael R. Gorman, David K. Welsh, Pamela L. Mellon, Hanne M. Hoffmann
Publikováno v:
Molecular Metabolism, Vol 57, Iss , Pp 101431- (2022)
Objective: The increasing prevalence of obesity makes it important to increase the understanding of the maturation and function of the neuronal integrators and regulators of metabolic function. Methods: Behavioral, molecular, and physiological analys
Externí odkaz:
https://doaj.org/article/600c4c304fde4903a956dadec4508da6
Autor:
Nathalie Coré, Andrea Erni, Hanne M Hoffmann, Pamela L Mellon, Andrew J Saurin, Christophe Beclin, Harold Cremer
Publikováno v:
eLife, Vol 9 (2020)
Different subtypes of interneurons, destined for the olfactory bulb, are continuously generated by neural stem cells located in the ventricular and subventricular zones along the lateral forebrain ventricles of mice. Neuronal identity in the olfactor
Externí odkaz:
https://doaj.org/article/e17c0541d63c4c298da3b578275d2f26
Autor:
Huimin Xie, Hanne M. Hoffmann, Anita K. Iyer, Melissa J. Brayman, Cindy Ngo, Mary Jean Sunshine, Pamela L. Mellon
Publikováno v:
Reproductive Biology and Endocrinology, Vol 15, Iss 1, Pp 1-11 (2017)
Abstract Background Proper expression of key reproductive hormones from gonadotrope cells of the pituitary is required for pubertal onset and reproduction. To further our understanding of the molecular events taking place during embryonic development
Externí odkaz:
https://doaj.org/article/561860d91a1a47f494c318fe109167e5
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158597 (2016)
Gonadotropin-releasing hormone (GnRH), a neuropeptide released from a small population of neurons in the hypothalamus, is the central mediator of the hypothalamic-pituitary-gonadal axis, and is required for normal reproductive development and functio
Externí odkaz:
https://doaj.org/article/b86b94e9533b43c1b8196482e716c11d
Publikováno v:
Molecular and Cellular Biology. 14:5592-5602
The human glycoprotein hormone alpha-subunit gene is expressed in two quite dissimilar tissues, the placenta and anterior pituitary. Tissue-specific expression is determined by combinations of elements, some of which are common and others of which ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2788821514babe19b6ebacab5666c77d
https://doi.org/10.1128/mcb.14.8.5592-5602.1994
https://doi.org/10.1128/mcb.14.8.5592-5602.1994
Publikováno v:
Molecular and Cellular Biology. 12:2143-2153
The molecular mechanisms for the development of multiple distinct endocrine cell types in the anterior pituitary have been an area of intensive investigation. Though the homeodomain protein Pit-1/GHF-1 is known to be involved in differentiation of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5c8d5eff440a03bd0dbbf0634637c3
https://doi.org/10.1128/mcb.12.5.2143-2153.1992
https://doi.org/10.1128/mcb.12.5.2143-2153.1992
Autor:
F, Pernasetti, V V, Vasilyev, S B, Rosenberg, J S, Bailey, H J, Huang, W L, Miller, P L, Mellon
Publikováno v:
Endocrinology. 142(6)
FSH is secreted by gonadotropes of the anterior pituitary and plays a crucial role in mammalian reproduction. However, little is known about FSH gene regulation due to the lack of a gonadotrope cell line that synthesizes FSH. The LbetaT2 mouse pituit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::60a7663668dd9521ce5abb1beb284dc5
https://pubmed.ncbi.nlm.nih.gov/11356674
https://pubmed.ncbi.nlm.nih.gov/11356674