Zobrazeno 1 - 10
of 73
pro vyhledávání: '"P Kondababu"'
Akademický článek
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Autor:
Lonneke Rotteveel, Alex J. Poot, Esther J. M. Kooijman, Robert C. Schuit, Ingrid Schalij, Xiaoqing Sun, Kondababu Kurakula, Chris Happé, Wissam Beaino, Peter ten Dijke, Adriaan A. Lammertsma, Harm Jan Bogaard, Albert D. Windhorst
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Transforming growth factor β (TGFβ) activity is perturbed in remodelled pulmonary vasculature of patients with pulmonary arterial hypertension (PAH), cancer, vascular diseases and developmental disorders. Inhibition of TGFβ, which signals
Externí odkaz:
https://doaj.org/article/d4e5834623554ec79cfeb8672ef8eb29
Akademický článek
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Autor:
Olga Tura-Ceide, Valérie F. E. D. Smolders, Núria Aventin, Constanza Morén, Mariona Guitart-Mampel, Isabel Blanco, Lucilla Piccari, Jeisson Osorio, Cristina Rodríguez, Montserrat Rigol, Núria Solanes, Andrea Malandrino, Kondababu Kurakula, Marie Jose Goumans, Paul H. A. Quax, Victor I. Peinado, Manuel Castellà, Joan Albert Barberà
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Pulmonary endarterectomy (PEA) resected material offers a unique opportunity to develop an in vitro endothelial cell model of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to comprehensively analyze the endothelial function
Externí odkaz:
https://doaj.org/article/754ae83577394ffaaec8967753372381
Autor:
Quint A. J. Hagdorn, Kondababu Kurakula, Anne-Marie C. Koop, Guido P. L. Bossers, Emmanouil Mavrogiannis, Tom van Leusden, Diederik E. van der Feen, Rudolf A. de Boer, Marie-José T. H. Goumans, Rolf M. F. Berger
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
BackgroundRight ventricular (RV) function and failure are key determinants of morbidity and mortality in various cardiovascular diseases. Myocardial fibrosis is regarded as a contributing factor to heart failure, but its importance in RV failure has
Externí odkaz:
https://doaj.org/article/59a9886305c849eb969d7513d719491a
Autor:
Chantal Kroone, Mariska Vos, Timo Rademakers, Marijke Kuijpers, Mark Hoogenboezem, Jaap van Buul, Johan W.M. Heemskerk, Wolfram Ruf, Astrid van Hylckama Vlieg, Henri H. Versteeg, Marie-José Goumans, Carlie J.M. de Vries, Kondababu Kurakula, INVENT Consortium
Publikováno v:
Haematologica, Vol 105, Iss 6 (2020)
Bleeding disorders and thrombotic complications are major causes of morbidity and mortality with many cases being unexplained. Thrombus formation involves aberrant expression and activation of tissue factor (TF) in vascular endothelial and smooth mus
Externí odkaz:
https://doaj.org/article/641ed4c9f0bc46ff9923379992fff131
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Julie Birkmose Axelsen, Stine Andersen, Xiao-Qing Sun, Steffen Ringgaard, Janus Adler Hyldebrandt, Kondababu Kurakula, Marie-José Goumans, Frances S de Man, Jens Erik Nielsen-Kudsk, Harm-Jan Bogaard, Asger Andersen
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225122 (2019)
BackgroundSeveral antineoplastic drugs have been proposed as new compounds for pulmonary arterial hypertension treatment but many have cardiotoxic side effects. The chemotherapeutic agent 6-mercaptopurine may have an effect in treatment of pulmonary
Externí odkaz:
https://doaj.org/article/fe22132dc37e4210a73b65f1441a40cb
Autor:
Valérie F. E. D. Smolders, Kirsten Lodder, Cristina Rodríguez, Olga Tura-Ceide, Joan Albert Barberà, J. Wouter Jukema, Paul H. A. Quax, Marie José Goumans, Kondababu Kurakula
Publikováno v:
Cells, Vol 10, Iss 4, p 737 (2021)
Chronic thromboembolic pulmonary hypertension (CTEPH) is a form of pulmonary hypertension characterized by the presence of fibrotic intraluminal thrombi and causing obliteration of the pulmonary arteries. Although both endothelial cell (EC) dysfuncti
Externí odkaz:
https://doaj.org/article/92e89d0b6ea74e5cb5166e46930fc231
Autor:
Wineke Bakker, Calinda K. E. Dingenouts, Kirsten Lodder, Karien C. Wiesmeijer, Alwin de Jong, Kondababu Kurakula, Hans-Jurgen J. Mager, Anke M. Smits, Margreet R. de Vries, Paul H. A. Quax, Marie José T. H. Goumans
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2010 (2021)
Hereditary hemorrhagic telangiectasia type 1 (HHT1) is a severe vascular disorder caused by mutations in the TGFβ/BMP co-receptor endoglin. Endoglin haploinsufficiency results in vascular malformations and impaired neoangiogenesis. Furthermore, HHT1
Externí odkaz:
https://doaj.org/article/90b85094c14344aa8023dd031682d605