Zobrazeno 1 - 10
of 529
pro vyhledávání: '"P Klarenbeek"'
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110268- (2024)
Summary: The outcome of cell signaling depends not only on signal strength but also on temporal progression. We use Fluorescence Lifetime Imaging of Resonance Energy Transfer (FLIM/FRET) biosensors to investigate intracellular signaling dynamics. We
Externí odkaz:
https://doaj.org/article/31c1435066444e929e0fb686efc30850
Autor:
Stefan J. Jodl, Wouter tenVoorde, Stefan Klein, Andrea Wagenfeld, Frank S. Zollmann, Maximilian Feldmüller, Naomi B. Klarenbeek, Digna T. deBruin, Manon A. A. Jansen, Robert Rissmann, Beate Rohde, Matthijs Moerland
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract This study evaluated and characterized the pharmacological activity of the orally administered interleukin‐1 receptor‐associated kinase 4 (IRAK4) inhibitors BAY1834845 (zabedosertib) and BAY1830839 in healthy male volunteers. Participant
Externí odkaz:
https://doaj.org/article/89d49a01219946438e0011ce97dc1147
Autor:
Wouter tenVoorde, Chika Akinseye, Ismahaan Abdisalaam, Selinde Wind, Naomi Klarenbeek, Menthe Bergmans, Martijn vanDoorn, Robert Rissmann, Rejbinder Kaur, Sarah Hotee, Katie Foster, Arati Nair, Lea Fortunato, Colin Macphee, Sarah Mole, Katrine Baumann, Richard Brigandi
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 10, Pp 1856-1865 (2023)
Abstract Pharmacological challenge models are deployed to evaluate drug effects during clinical development. Intradermal injection of Substance P (SP) neuropeptide, a potential challenge agent for investigating local mediators, is associated with whe
Externí odkaz:
https://doaj.org/article/08287e6b2cc64b848f3fdbb071032292
Autor:
Tim Somers, Bastiaan R. Klarenbeek, Ilse J.E. Kouijzer, Ad F.T.M. Verhagen, Michel W.A. Verkroost
Publikováno v:
Journal of Cardiothoracic Surgery, Vol 18, Iss 1, Pp 1-7 (2023)
Abstract Background Aortic mycotic aneurysms are a rare but life-threatening condition and may be associated with aorto-bronchial- and aorto-esophageal fistulas. Although both very rare, they carry a high mortality and require (urgent) surgical inter
Externí odkaz:
https://doaj.org/article/e5247af36c4e4859b86826280589a181
Autor:
Maria J Valkema, Anne‐Marie Vos, Rachel S van derPost, Ariadne HAG Ooms, Lindsey Oudijk, Ben M Eyck, Sjoerd M Lagarde, Bas PL Wijnhoven, Bastiaan R Klarenbeek, Camiel Rosman, J Jan B vanLanschot, Michail Doukas
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 9, Iss 4, Pp 322-335 (2023)
Abstract Oesophageal adenocarcinomas may show different histopathological patterns, including excessive acellular mucin pools, signet‐ring cells (SRCs), and poorly cohesive cells (PCCs). These components have been suggested to correlate with poor o
Externí odkaz:
https://doaj.org/article/466ad4fe0e77426db65ebbc7e2315116
Autor:
N M Bosch, A J Kalkdijk-Dijkstra, P M A Broens, H L van Westreenen, J P E N Pierie, B R Klarenbeek, J A G van der Heijden, FORCE trial group
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0301518 (2024)
BackgroundPelvic Floor Rehabilitation (PFR) is effective in a selection of patients with low anterior resection syndrome (LARS) after rectal cancer surgery. This study aimed to identify barriers and enablers to prepare for successful implementation i
Externí odkaz:
https://doaj.org/article/4649fbfbcd054192b67004f19f438be1
Autor:
Francesca De Ridder, Rie Braspenning, Juan S Ordonez, Gijs Klarenbeek, Patrick Lauwers, Kristien J Ledeganck, Danaë Delbeke, Christophe De Block
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0301041 (2024)
ObjectiveTo evaluate the safety and performance of an implantable near-infrared (NIR) spectroscopy sensor for multi-metabolite monitoring of glucose, ketones, lactate, and ethanol.Research design and methodsThis is an early feasibility study (GLOW, N
Externí odkaz:
https://doaj.org/article/2b90ce2c8f9a42db821350a7ce210a24
Autor:
Olga S. Blomberg, Kevin Kos, Lorenzo Spagnuolo, Olga I. Isaeva, Hannah Garner, Max D. Wellenstein, Noor Bakker, Danique E.M. Duits, Kelly Kersten, Sjoerd Klarenbeek, Cheei-Sing Hau, Daphne Kaldenbach, Elisabeth A.M. Raeven, Kim Vrijland, Marleen Kok, Karin E. de Visser
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTThe clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients have recently spurred the clinical implementation of ICB in the neoadjuvant and perioperative setting. However, how neoadjuvant ICB therapy affects the sys
Externí odkaz:
https://doaj.org/article/b656e036ddb5458b8a3bb50ca339a61b
Autor:
Willem de Laat, Lisa Pagan, R. Karl Malcolm, Maarten Wiegerinck, Victor Nickolson, Bertine Huisman, Rik Stuurman, Michiel van Esdonk, Naomi Klarenbeek
Publikováno v:
Drug Delivery, Vol 30, Iss 1 (2023)
AbstractPolymeric drug-releasing vaginal rings are useful for both local and systemic administration of drugs via the intravaginal route. Typically, they provide continuous sustained or controlled release of drug(s) over extended time periods, thereb
Externí odkaz:
https://doaj.org/article/4787f941be144ec396a0d86999b07d4b
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