Zobrazeno 1 - 10
of 24
pro vyhledávání: '"P K Working"'
Publikováno v:
Human & Experimental Toxicology. 18:17-26
1 The multiple dose pharmacokinetics of pegylated liposomal doxorubicin (PL-DOX), known as DOXIL® (US) and CAELYX® (EU), was characterized in dogs and a pharmacokinetic/pharmacodynamic model to identify a relationship between drug exposure and the
Publikováno v:
Journal of Liposome Research. 4:667-687
Doxil® (Stealth® liposomal doxorubicin HCl) Injection is doxorubicin HCl incorporated into long circulating liposomes that contain surface-grafted polyoxyethylene chains. These surface-grafted poly...
Publikováno v:
Current opinion in molecular therapeutics. 1(2)
The introduction of colloidally stable liposomes with low drug leakage rates resulted in a renaissance in liposome applications in cancer therapy. Furthermore, a platform of sterically stabilized liposomes also allows the construction of new generati
Autor:
R Z, Yu, R S, Geary, J M, Leeds, T, Watanabe, J R, Fitchett, J E, Matson, R, Mehta, G R, Hardee, M V, Templin, K, Huang, M S, Newman, Y, Quinn, P, Uster, G, Zhu, P K, Working, M, Horner, J, Nelson, A A, Levin
Publikováno v:
Pharmaceutical research. 16(8)
This study examined the pharmacokinetics and tissue distribution of an antisense oligonucleotide ISIS 2503, formulated in stealth (pegylated) liposomes (encapsulated) or in phosphate-buffered saline (unencapsulated).Encapsulated or unencapsulated ISI
Autor:
P K, Working
Publikováno v:
Chemotherapy. 45
Amphotericin B Colloidal Dispersion (ABCD, AmphocilTM), a noncovalent complex of amphotericin B and cholesteryl sulfate, is active in vitro and in vivo against a wide variety of fungal species; its activity is broadly comparable to the range of activ
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(2)
The relative cardiotoxicity of pegylated (STEALTH) liposomal doxorubicin (PL-DOX; Doxil) was compared to nonliposomal doxorubicin (Adriamycin) in rabbits and dogs treated i.v. for up to 22 weeks. No histological evidence of cardiotoxicity was seen in
Autor:
G T, Colbern, D J, Dykes, C, Engbers, R, Musterer, A, Hiller, E, Pegg, R, Saville, S, Weng, M, Luzzio, P, Uster, M, Amantea, P K, Working
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 4(12)
The topoisomerase I inhibitor GL147211C [7-[(4-methylpiperazino)methyl]-10,11-(ethylenedioxy)-(20S)-campto thecin trifluoroacetate], a camptothecin analogue, has significant activity in tumor cell cytotoxicity assays in vitro and antitumor activity i
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 4(1)
The introduction of long-circulating liposomes sterically stabilized by surface coating with polyethylene glycol has expanded the potential for drug targeting to tumors. In recent clinical studies, evidence of significant antitumor activity has been
Autor:
P K, Working, A D, Dayan
Publikováno v:
Humanexperimental toxicology. 15(9)
The purpose of this study was to evaluate the pharmacokinetics of amphotericin B colloidal dispersion and its effect on creatinine clearance in bone marrow transplant patients with systemic fungal infections. Seventy-five patients (42 females and 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d69845ccb86526c60694875b58928a
https://europepmc.org/articles/PMC162878/
https://europepmc.org/articles/PMC162878/