Zobrazeno 1 - 10
of 17
pro vyhledávání: '"P K L, Leung"'
Autor:
Tong Wang, Kush Coshic, Mohsen Badiee, Maranda R. McDonald, Aleksei Aksimentiev, Lois Pollack, Anthony K. L. Leung
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Poly(ADP-ribose) (PAR), a non-canonical nucleic acid, is essential for DNA/RNA metabolism and protein condensation, and its dysregulation is linked to cancer and neurodegeneration. However, key structural insights into PAR’s functions rema
Externí odkaz:
https://doaj.org/article/d64792a0269a42c181b4da287b581609
Autor:
Lena Münzker, Serah W. Kimani, Milan M. Fowkes, Aiping Dong, Hong Zheng, Yanjun Li, Morgan Dasovich, Krzysztof M. Zak, Anthony K. L. Leung, Jonathan M. Elkins, Dirk Kessler, Cheryl H. Arrowsmith, Levon Halabelian, Jark Böttcher
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract The WWE domain is a relatively under-researched domain found in twelve human proteins and characterized by a conserved tryptophan-tryptophan-glutamate (WWE) sequence motif. Six of these WWE domain-containing proteins also contain domains wit
Externí odkaz:
https://doaj.org/article/d563b7d731e84d30bedff15301871bf2
Autor:
Tong Wang, Kush Coshic, Mohsen Badiee, Maranda R. McDonald, Aleksei Aksimentiev, Lois Pollack, Anthony K. L. Leung
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/fc9a7280af254c76a7b6ee8807993b1a
Autor:
Qian Chen, Kai Ma, Xiuhua Liu, Shih-Hsun Chen, Peng Li, Yonghao Yu, Anthony K. L. Leung, Xiaochun Yu
Publikováno v:
Cell Discovery, Vol 8, Iss 1, Pp 1-19 (2022)
Abstract Caspase-mediated cleavage of PARP1 is a surrogate marker for apoptosis. However, the biological significance of PARP1 cleavage during apoptosis is still unclear. Here, using unbiased protein affinity purification, we show that truncated PARP
Externí odkaz:
https://doaj.org/article/eea60e67368c4ea5af8b3e599a928c31
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-10 (2021)
Abstract Background Five different sacral fracture fixation methods were compared using finite element (FE) analysis to study their biomechanical characteristics. Methods Denis type I sacral fractures were created by FE modeling. Five different fixat
Externí odkaz:
https://doaj.org/article/dc30c43b3a404e309f2f449114b87b70
Autor:
Brian H.M. Sit, Kathy Hiu Laam Po, Yuk-Yam Cheung, Alan K. L. Tsang, Patricia K. L. Leung, J. Zheng, Alison Y. T. Lam, Edman T. K. Lam, Ken H. L. Ng, Rickjason C. W. Chan
Publikováno v:
Journal of Clinical Virology Plus, Vol 2, Iss 3, Pp 100091- (2022)
Summary: Objectives: The World Health Organization (WHO) had designated the SARS-CoV-2 lineage B.1.1.529 as the new Variant of Concern Omicron (VOC-Omicron) on 26th November 20211. Real-time reverse transcription polymerase chain reaction (RT-PCR), s
Externí odkaz:
https://doaj.org/article/85b0de8e4c734581bc130d1f8407800a
Publikováno v:
Bone & Joint Research, Vol 10, Iss 2, Pp 105-112 (2021)
Aims: To draw a comparison of the pullout strengths of buttress thread, barb thread, and reverse buttress thread bone screws. Methods: Buttress thread, barb thread, and reverse buttress thread bone screws were inserted into synthetic cancellous bone
Externí odkaz:
https://doaj.org/article/65925777173d4acca4493ae1e0d0726d
Publikováno v:
Viruses, Vol 15, Iss 2, p 449 (2023)
Viruses depend on host cellular resources to replicate. Interaction between viral and host proteins is essential for the pathogens to ward off immune responses as well as for virus propagation within the infected cells. While different viruses employ
Externí odkaz:
https://doaj.org/article/206b0e065f14427eb5dad5eb72be78cb
Autor:
Rachy Abraham, Robert L. McPherson, Morgan Dasovich, Mohsen Badiee, Anthony K. L. Leung, Diane E. Griffin
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Macrodomain (MD), a highly conserved protein fold present in a subset of plus-strand RNA viruses, binds to and hydrolyzes ADP-ribose (ADPr) from ADP-ribosylated proteins. ADPr-binding by the alphavirus nonstructural protein 3 (nsP3) MD is ne
Externí odkaz:
https://doaj.org/article/f14fda4fa606414e8071d7efbec069d1
Publikováno v:
Pathogens, Vol 11, Iss 1, p 94 (2022)
Emerging and re-emerging viral diseases pose continuous public health threats, and effective control requires a combination of non-pharmacologic interventions, treatment with antivirals, and prevention with vaccines. The COVID-19 pandemic has demonst
Externí odkaz:
https://doaj.org/article/ed48111fe8204080a38d03ee82583188