Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas

Autor: Priscilla K. Brastianos, Albert E. Kim, Anita Giobbie-Hurder, Eudocia Quant Lee, Nancy Wang, April F. Eichler, Ugonma Chukwueke, Deborah A. Forst, Isabel C. Arrillaga-Romany, Jorg Dietrich, Zachary Corbin, Jennifer Moliterno, Joachim Baehring, Michael White, Kevin W. Lou, Juliana Larson, Magali A. de Sauvage, Kathryn Evancic, Joana Mora, Naema Nayyar, Jay Loeffler, Kevin Oh, Helen A. Shih, William T. Curry, Daniel P. Cahill, Fred G. Barker, Elizabeth R. Gerstner, Sandro Santagata

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)

Abstract High-grade meningiomas are associated with neuro-cognitive morbidity and have limited treatments. High-grade meningiomas harbor an immunosuppressive tumor microenvironment (TME) and programmed death-ligand 1 (PD-L1) expression may contribute

Externí odkaz: https://doaj.org/article/151a61114ef3419098315fb6862b5008

Phase II study of ipilimumab and nivolumab in leptomeningeal carcinomatosis

Autor: Priscilla K. Brastianos, Matthew R. Strickland, Eudocia Quant Lee, Nancy Wang, Justine V. Cohen, Ugonma Chukwueke, Deborah Anne Forst, April Eichler, Beth Overmoyer, Nancy U. Lin, Wendy Y. Chen, Aditya Bardia, Dejan Juric, Ibiayi Dagogo-Jack, Michael D. White, Jorg Dietrich, Naema Nayyar, Albert E. Kim, Christopher Alvarez-Breckenridge, Maura Mahar, Joana L. Mora, Brian V. Nahed, Pamela S. Jones, Helen A. Shih, Elizabeth R. Gerstner, Anita Giobbie-Hurder, Scott L. Carter, Kevin Oh, Daniel P. Cahill, Ryan J. Sullivan

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)

Leptomeningeal metastases from solid tumors are a rare complication with a very poor prognosis. Here the authors report the efficacy and safety of combined ipilimumab and nivolumab in patients with leptomeningeal carcinomatosis.

Externí odkaz: https://doaj.org/article/b04f3eeb51ed4432b18eeaf9f4a73076

Sporadic multiple meningiomas harbor distinct driver mutations

Autor: Tareq A. Juratli, Insa Prilop, Felix C. Saalfeld, Sylvia Herold, Matthias Meinhardt, Carina Wenzel, Silke Zeugner, Daniela E. Aust, Fred G. Barker, Daniel P. Cahill, Priscilla K. Brastianos, Sandro Santagata, Gabriele Schackert, Thomas Pinzer

Publikováno v: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-4 (2021)

Externí odkaz: https://doaj.org/article/1e680a3127184b6993515635f457bbbd

Development of ‘Core Outcome Sets’ for Meningioma in Clinical Studies (The COSMIC Project): protocol for two systematic literature reviews, eDelphi surveys and online consensus meetings

Autor: James Snyder, Nisaharan Srikandarajah, Boris Krischek, Matthias Preusser, Michael Weller, Timothy J Kaufmann, Thomas Santarius, Carole Turner, Michael D Cusimano, Paula R Williamson, Michael McDermott, Michael D Jenkinson, Justin Wang, Mohsen Javadpour, Andrea Saladino, Anthony G Marson, David James, Chaya Brodie, Daniel M Fountain, Roland Goldbrunner, Felix Sahm, Sylvia Kurz, Colin Watts, Julian Spears, Amir H Zamanipoor Najafabadi, Simon Walling, Andrew Morokoff, Ghazaleh Tabatabai, Helen Shih, Linda Dirven, Puneet Plaha, Helen Bulbeck, David Schultz, Christian Mawrin, Jens Schittenhelm, Farshad Nassiri, Martin J B Taphoorn, Manfred Westphal, Warren Selman, C Oliver Hanemann, Patrick Y Wen, Mirjam Renovanz, Evanthia Galanis, Alireza Mansouri, Priscilla K Brastianos, Christine Jungk, Heather Barrington, Aaron Cohen-Gadol, Gelareh Zadeh, Abdurrahman I Islim, Christopher P Millward, Theo Georgious, Andrew R Brodbelt, Karolyn Au, Felix Behling, Nicholas Butowski, Ana Castro, Marta Couce, Francesco Dimeco, Craig Erker, Michelle Felicella, Norbert Galldiks, Caterina Giannini, Christel Herold-Mende, Luke Hnenny, Craig Horbinski, Gerhard Jungwirth, Daniel Lachance, Christian Lafougere, Katrin Lamszus, Serge Makarenko, Tathiana Malta, Jennifer Moliterno-Gunel, Houtan Noushmehr, Arie Perry, Aditya Ragunathan, David Raleigh, Franz Ricklefs, Antonio Santacroce, Christian Schichor, Andrew Sloan, Matija Snuderl, Erik Sulman, Suganth Suppiah, Marcos Tatagiba, Marco Timmer, Andreas Von Deimling, Tobias Walbert, Stephen Yip, Gabriel Zada, Viktor Zherebitskiy, Derek Tsang, Kenneth Aldape, Terri S Armstrong, Sabrina Bell, Anna Crofton, Paul L Grundy, Sumirat M Keshwara, Shelli D Koszdin, Michael W McDermott, Torstein R Meling, Kathy Oliver, Jill Barnhartz-Sloan, Wenya Linda Bi, Carlos Carlotti, Katharine Drummond, Ian F Dunn, Brent Griffith, Rintaro Hashizume, Raymond Y Huang, Ian Lee, Jeff C Liu, Yasin Mamatjan, David Munoz, Ho-Keung Ng, Farhad Pirouzmand, Laila M Poisson, Bianca Pollo, Nils O Schmidt, Daniela Tirapelli, Joerg C Tonn, Michael A Vogelbaum, Adriana M Workewych

Publikováno v: BMJ Open, Vol 12, Iss 5 (2022)

Introduction Meningioma is the most common primary intracranial tumour in adults. The majority are non-malignant, but a proportion behave more aggressively. Incidental/minimally symptomatic meningioma are often managed by serial imaging. Symptomatic

Externí odkaz: https://doaj.org/article/e6f0561f8df642f8988cb2020bf5eb8a

Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors

Autor: Andrew L Mammen, Jarushka Naidoo, Divyanshu Dubey, Michael Dougan, Teilo H Schaller, Meghan J Mooradian, Douglas B Johnson, Jorg Dietrich, Leyre Zubiri, Tomas G Neilan, Bianca D Santomasso, Ryan J Sullivan, Kerry L Reynolds, Allison Betof Warner, Justine V Cohen, Nancy Wang, Jenny Linnoila, Jeffrey M Gelfand, Anthony A Amato, Stacey L Clardy, David A Reardon, William C Louv, Amanda C Guidon, Leeann B Burton, Bart K Chwalisz, James Hillis, Priscilla K Brastianos, Tracey A Cho, Christopher T Doughty, Jeffrey T Guptill, Vern C Juel, Robert Kadish, Noah Kolb, Nicole R LeBoeuf, Maria Martinez-Lage, Krista M Rubin, Karin Woodman

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)

Expanding the US Food and Drug Administration–approved indications for immune checkpoint inhibitors in patients with cancer has resulted in therapeutic success and immune-related adverse events (irAEs). Neurologic irAEs (irAE-Ns) have an incidence

Externí odkaz: https://doaj.org/article/a2206707f599451b8603379684ad2015