Zobrazeno 1 - 10
of 20
pro vyhledávání: '"P K, Madala"'
Autor:
Santhoshi V. Akkenepally, Dan J. K. Yombo, Sanjana Yerubandi, Geereddy Bhanuprakash Reddy, Deepak A. Deshpande, Francis X. McCormack, Satish K. Madala
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Asthma is a chronic inflammatory airway disease characterized by airway hyperresponsiveness (AHR), inflammation, and goblet cell hyperplasia. Multiple cytokines, including IFNγ, IL-4, and IL-13 are associated with asthma; however, the mecha
Externí odkaz:
https://doaj.org/article/afb44756c2a84b2a9424fac53d1b188a
Autor:
Rajesh K Kasam, Sudhir Ghandikota, Divyalakshmi Soundararajan, Geereddy B Reddy, Steven K Huang, Anil G Jegga, Satish K Madala
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 9, Pp 1-16 (2020)
Abstract Fibroblast activation including proliferation, survival, and ECM production is central to initiation and maintenance of fibrotic lesions in idiopathic pulmonary fibrosis (IPF). However, druggable molecules that target fibroblast activation r
Externí odkaz:
https://doaj.org/article/2a97e233e5134721ba0d532a1b18172e
Autor:
Prathibha R. Gajjala, Rajesh K. Kasam, Divyalakshmi Soundararajan, Debora Sinner, Steven K. Huang, Anil G. Jegga, Satish K. Madala
Publikováno v:
JCI Insight, Vol 6, Iss 20 (2021)
Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease associated with unremitting fibroblast activation including fibroblast-to-myofibroblast transformation (FMT), migration, resistance to apoptotic clearance, and excessive deposition
Externí odkaz:
https://doaj.org/article/7ef0baed6eb54da187d0588fc7b35816
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Idiopathic Pulmonary Fibrosis (IPF) is a severe fibrotic lung disease characterized by excessive collagen deposition and progressive decline in lung function. Th2 T cell-derived cytokines including IL-4 and IL-13 have been shown to contribute to infl
Externí odkaz:
https://doaj.org/article/f8a8596e4ecf48c5b44741dd87ad8eb5
Autor:
Yunguan Wang, Jaswanth K. Yella, Sudhir Ghandikota, Tejaswini C. Cherukuri, Harshavardhana H. Ediga, Satish K. Madala, Anil G. Jegga
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 14 (2020)
Background: There are two US Food and Drug Administration (FDA)-approved drugs, pirfenidone and nintedanib, for treatment of patients with idiopathic pulmonary fibrosis (IPF). However, neither of these drugs provide a cure. In addition, both are asso
Externí odkaz:
https://doaj.org/article/9955bde817bc4380bf3f9f7ed99d832c
Autor:
Yunguan Wang, Jaswanth Yella, Jing Chen, Francis X. McCormack, Satish K. Madala, Anil G. Jegga
Publikováno v:
BMC Pulmonary Medicine, Vol 17, Iss 1, Pp 1-10 (2017)
Abstract Background Idiopathic Pulmonary Fibrosis (IPF) is a fatal fibrotic lung disease occurring predominantly in middle-aged and older adults. The traditional diagnostic classification of IPF is based on clinical, radiological, and histopathologic
Externí odkaz:
https://doaj.org/article/57655e684e254a7e95d3c381f18a354c
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Impaired apoptotic clearance of myofibroblasts can result in the continuous expansion of scar tissue during the persistent injury in the lung. However, the molecular and cellular mechanisms underlying the apoptotic clearance of multiple mesenchymal c
Externí odkaz:
https://doaj.org/article/1e36da0321e4439686f7c238c6b03779
Autor:
Brijendra Singh, Anil G Jegga, Kumar S Shanmukhappa, Ramakrishna Edukulla, Gurjit Kaur Khurana Hershey, Mario Medvedovic, Stacey R Dillon, Satish K Madala
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170446 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0161877.].
Externí odkaz:
https://doaj.org/article/42749d9088f54048834c96533886ade3
Autor:
Brijendra Singh, Anil G Jegga, Kumar S Shanmukhappa, Ramakrishna Edukulla, Gurjit H Khurana Hershey, Mario Medvedovic, Stacey R Dillon, Satish K Madala
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161877 (2016)
Interleukin-31 (IL-31) is a type 2 helper T-cell-derived cytokine that has recently been shown to cause severe inflammation and tissue remodeling in multiple chronic diseases of the skin and lungs. IL-31 is upregulated in allergic and inflammatory di
Externí odkaz:
https://doaj.org/article/ea32bb4149e947fc8fc884016771bf35
Autor:
Yan Huang, Corey Powers, Satish K Madala, Kenneth D Greis, Wendy D Haffey, Jeffrey A Towbin, Enkhsaikhan Purevjav, Sabzali Javadov, Arnold W Strauss, Zaza Khuchua
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128561 (2015)
Cardiolipin (CL) is a mitochondrial phospholipid essential for electron transport chain (ETC) integrity. CL-deficiency in humans is caused by mutations in the tafazzin (Taz) gene and results in a multisystem pediatric disorder, Barth syndrome (BTHS).
Externí odkaz:
https://doaj.org/article/dd94a5c23f734988bfe595aef3d98094