Zobrazeno 1 - 10
of 66
pro vyhledávání: '"P K, Cheema"'
Autor:
Alana D. Carpenter, Keirstyn M. Empfield, Sarah A. Petrus, Oluseyi O. Fatanmi, Stephen Y. Wise, John B. Tyburski, Amrita K. Cheema, Vijay K. Singh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Exposure to ionizing radiation induces cellular and molecular damage leading to a cascade of events resulting in tissue and organ injury. Our study strives to characterize and validate metabolomic changes in preterminal stage (immediately pr
Externí odkaz:
https://doaj.org/article/d4401c716e9e4266ab0d2bd292060434
Autor:
Alana D. Carpenter, Oluseyi O. Fatanmi, Stephen Y. Wise, John B. Tyburski, Amrita K. Cheema, Vijay K. Singh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The identification and validation of radiation biomarkers is critical for assessing the radiation dose received in exposed individuals and for developing radiation medical countermeasures that can be used to treat acute radiation syndrome (A
Externí odkaz:
https://doaj.org/article/2f344ce7dbcf4ad594ec6e0c5dfd951e
Autor:
Ales Tichy, Alana D. Carpenter, Yaoxiang Li, Gabriela Rydlova, Pavel Rehulka, Marketa Markova, Marcela Milanova, Vojtech Chmil, Amrita K. Cheema, Vijay K. Singh
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9208 (2024)
In the last decade, geopolitical instability across the globe has increased the risk of a large-scale radiological event, when radiation biomarkers would be needed for an effective triage of an irradiated population. Ionizing radiation elicits a comp
Externí odkaz:
https://doaj.org/article/af1324dd554c4e30ab632c5132e8adcb
Autor:
Shreyans K. Jain, Shivani Bansal, Sunil Bansal, Baldev Singh, William Klotzbier, Khyati Y. Mehta, Amrita K. Cheema
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5901 (2024)
Accurate and reliable quantification of organic acids with carboxylic acid functional groups in complex biological samples remains a major analytical challenge in clinical chemistry. Issues such as spontaneous decarboxylation during ionization, poor
Externí odkaz:
https://doaj.org/article/fa4b00af2c11427b8d194f69b2167311
Autor:
Parneet K. Cheema, Shantanu O. Banerji, Normand Blais, Quincy S.-C. Chu, Rosalyn A. Juergens, Natasha B. Leighl, Adrian Sacher, Brandon S. Sheffield, Stephanie Snow, Mark Vincent, Paul F. Wheatley-Price, Stephen Yip, Barbara L. Melosky
Publikováno v:
Current Oncology, Vol 30, Iss 7, Pp 6473-6496 (2023)
Activating mutations in Kirsten rat sarcoma viral oncogene homologue (KRAS), in particular, a point mutation leading to a glycine-to-cysteine substitution at codon 12 (G12C), are among the most frequent genomic alterations in non-small cell lung canc
Externí odkaz:
https://doaj.org/article/ab0cb512b2d24cbeafaef622627ed0b6
Autor:
Barbara L. Melosky, Natasha B. Leighl, David Dawe, Normand Blais, Paul F. Wheatley-Price, Quincy S.-C. Chu, Rosalyn A. Juergens, Peter M. Ellis, Alexander Sun, Devin Schellenberg, Diana N. Ionescu, Parneet K. Cheema
Publikováno v:
Current Oncology, Vol 30, Iss 7, Pp 6289-6315 (2023)
Small-cell lung cancer (SCLC) is an aggressive, neuroendocrine tumour with high relapse rates, and significant morbidity and mortality. Apart from advances in radiation therapy, progress in the systemic treatment of SCLC had been stagnant for over th
Externí odkaz:
https://doaj.org/article/4018347cac8e41ddb2d0bdfcb844469e
Autor:
Hye Ryun Kim, MD, PhD, Mark M. Awad, MD, PhD, Alejandro Navarro, MD, Maya Gottfried, MD, Solange Peters, MD, PhD, Tibor Csőszi, MD, Parneet K. Cheema, MD, Delvys Rodriguez-Abreu, MD, PhD, Mirjana Wollner, MD, James Chih-Hsin Yang, MD, PhD, Julien Mazieres, MD, PhD, Francisco J. Orlandi, MD, Alexander Luft, MD, PhD, Mahmut Gümüş, MD, Terufumi Kato, MD, Gregory P. Kalemkerian, MD, Yiwen Luo, PhD, Melissa L. Santorelli, PhD, MPH, M. Catherine Pietanza, MD, Charles M. Rudin, MD, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 4, Iss 11, Pp 100572- (2023)
Introduction: In the phase 3 KEYNOTE-604 study (NCT03066778), pembrolizumab plus etoposide and platinum chemotherapy (EP) significantly (p = 0.0023) improved progression-free survival versus placebo plus EP in previously untreated extensive-stage SCL
Externí odkaz:
https://doaj.org/article/0e1816cce869459686df7d5b2f6d1a2d
Autor:
Shivani Bansal, Yaoxiang Li, Sunil Bansal, William Klotzbier, Baldev Singh, Meth Jayatilake, Vijayalakshmi Sridharan, José A. Fernández, John H. Griffin, Hartmut Weiler, Marjan Boerma, Amrita K. Cheema
Publikováno v:
Metabolites, Vol 14, Iss 5, p 245 (2024)
Exposure to ionizing radiation, accidental or intentional, may lead to delayed effects of acute radiation exposure (DEARE) that manifest as injury to organ systems, including the kidney, heart, and brain. This study examines the role of activated pro
Externí odkaz:
https://doaj.org/article/42a2683e6be948beab598818f29e7231
Autor:
Yaoxiang Li, Michael Girgis, Meth Jayatilake, Artur A. Serebrenik, Amrita K. Cheema, Michael D. Kaytor, Vijay K. Singh
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract BIO 300, a pharmaceutical formulation of genistein, is being developed as a radiation countermeasure to treat hematopoietic acute radiation syndrome (H-ARS) and the delayed effects of acute radiation exposure (DEARE). Several studies have af
Externí odkaz:
https://doaj.org/article/1fd6a8a4d1f645938839e42b36f38314
Autor:
Tiffany A. Fillier, Shrushti Shah, Karen M. Doody, Thu H. Pham, Isabelle Aubry, Michel L. Tremblay, Sukhinder K. Cheema, Jacqueline Blundell, Raymond H. Thomas
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Communication between gut microbiota and the brain is an enigma. Alterations in the gut microbial community affects enteric metabolite levels, such as short chain fatty acids (SCFAs). SCFAs have been proposed as a possible mechanism through
Externí odkaz:
https://doaj.org/article/b5d54eeb0b314ea2988f7514b326c0e7