Zobrazeno 1 - 10
of 105
pro vyhledávání: '"P Jeremy Wang"'
Autor:
Jessica Y Chotiner, N Adrian Leu, Fang Yang, Isabella G Cossu, Yongjuan Guan, Huijuan Lin, P Jeremy Wang
Publikováno v:
eLife, Vol 12 (2024)
Meiotic progression requires coordinated assembly and disassembly of protein complexes involved in chromosome synapsis and meiotic recombination. Mouse TRIP13 and its ortholog Pch2 are instrumental in remodeling HORMA domain proteins. HORMAD proteins
Externí odkaz:
https://doaj.org/article/0256f45fcbe84407aa849f5a310cbbd1
Autor:
Yongjuan Guan, Hongyan Gao, N Adrian Leu, Anastassios Vourekas, Panagiotis Alexiou, Manolis Maragkakis, Zhenlong Kang, Zissimos Mourelatos, Guanxiang Liang, P Jeremy Wang
Publikováno v:
PLoS Genetics, Vol 19, Iss 5, p e1010566 (2023)
Transposable elements constitute nearly half of the mammalian genome and play important roles in genome evolution. While a multitude of both transcriptional and post-transcriptional mechanisms exist to silence transposable elements, control of transp
Externí odkaz:
https://doaj.org/article/6fb3ccb1c174425a95ff36753cfe0893
Autor:
Natoya J Peart, Taylor A Johnson, Sungkyoung Lee, Matthew J Sears, Fang Yang, Mathieu Quesnel-Vallières, Huijuan Feng, Yocelyn Recinos, Yoseph Barash, Chaolin Zhang, Brian P Hermann, P Jeremy Wang, Christopher B Geyer, Russ P Carstens
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010416 (2022)
Control over gene expression is exerted, in multiple stages of spermatogenesis, at the post-transcriptional level by RNA binding proteins (RBPs). We identify here an essential role in mammalian spermatogenesis and male fertility for 'RNA binding prot
Externí odkaz:
https://doaj.org/article/53361225d7ba4d6abbf2e4eaf7ec0fd2
Publikováno v:
PLoS Genetics, Vol 17, Iss 2, p e1009265 (2021)
Piwi-interacting RNAs (piRNAs) play critical roles in protecting germline genome integrity and promoting normal spermiogenic differentiation. In mammals, there are two populations of piRNAs: pre-pachytene and pachytene. Transposon-rich pre-pachytene
Externí odkaz:
https://doaj.org/article/3652cb17792e47f59a1fba3e30233bcf
Autor:
Baolu Shi, Jiangyang Xue, Hao Yin, Rui Guo, Mengcheng Luo, Lan Ye, Qinghua Shi, Xiaoyan Huang, Mingxi Liu, Jiahao Sha, P Jeremy Wang
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007952 (2019)
Meiotic recombination permits exchange of genetic material between homologous chromosomes. The replication protein A (RPA) complex, the predominant ssDNA-binding complex, is required for nearly all aspects of DNA metabolism, but its role in mammalian
Externí odkaz:
https://doaj.org/article/164838f74e2645ec9d4de7ffd1f3ce3e
Autor:
Seth D Kasowitz, Jun Ma, Stephen J Anderson, N Adrian Leu, Yang Xu, Brian D Gregory, Richard M Schultz, P Jeremy Wang
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007412 (2018)
The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3' UTRs. Here we show that the nuclear m6A reader YTHDC1 is essential for embryo viabili
Externí odkaz:
https://doaj.org/article/96984f59b2b140f0a301bad88184fee4
Autor:
Baolu Shi, Jiangyang Xue, Jian Zhou, Seth D Kasowitz, Yuanwei Zhang, Guanxiang Liang, Yongjuan Guan, Qinghua Shi, Mingxi Liu, Jiahao Sha, Xiaoyan Huang, P Jeremy Wang
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007175 (2018)
The microrchidia (MORC) family proteins are chromatin-remodelling factors and function in diverse biological processes such as DNA damage response and transposon silencing. Here, we report that mouse Morc2b encodes a functional germ cell-specific mem
Externí odkaz:
https://doaj.org/article/6cf2830a2caa47e9ada36b7ee582e7c1
Autor:
Fang Yang, Sherman Silber, N Adrian Leu, Robert D Oates, Janet D Marszalek, Helen Skaletsky, Laura G Brown, Steve Rozen, David C Page, P Jeremy Wang
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 9, Pp 1198-1210 (2015)
Abstract Genome‐wide recombination is essential for genome stability, evolution, and speciation. Mouse Tex11, an X‐linked meiosis‐specific gene, promotes meiotic recombination and chromosomal synapsis. Here, we report that TEX11 is mutated in i
Externí odkaz:
https://doaj.org/article/06ab8592b1a94f92a6774617d9183d39
Autor:
Mengcheng Luo, Jian Zhou, N Adrian Leu, Carla M Abreu, Jianle Wang, Montserrat C Anguera, Dirk G de Rooij, Maria Jasin, P Jeremy Wang
Publikováno v:
PLoS Genetics, Vol 11, Iss 1, p e1004954 (2015)
Polycomb group proteins mediate transcriptional silencing in diverse developmental processes. Sex chromosomes undergo chromosome-wide transcription silencing during male meiosis. Here we report that mouse SCML2 (Sex comb on midleg-like 2), an X chrom
Externí odkaz:
https://doaj.org/article/621c5b5e66ee41edb4a88fdf68d700cc
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89471 (2014)
Tudor domain containing (Tdrd) proteins that are expressed in germ cells are divided into two groups. One group, consisting of TDRD1, TDRKH, TDRD9 and TDRD12, function in piRNA biogenesis and retrotransposon silencing, while the other group including
Externí odkaz:
https://doaj.org/article/44b6621a458941e0ab4e9c70bd0fe75b