Zobrazeno 1 - 10
of 13
pro vyhledávání: '"P J Worland"'
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 17, Iss 11, Pp 1242-1249 (2004)
Two mutants were isolated in wheat that showed enhanced resistance towards Puccinia striiformis f. sp. tritici, the fungal causal agent of yellow rust. The altered phenotype of I3-48 is due to a minimum of two mutation events, each showing a partial,
Externí odkaz:
https://doaj.org/article/2794217ab0c34adb8552054d259a107e
Publikováno v:
Agronomy Science, Vol 63, Iss 3 (2008)
W pracy badano linie rekombinacyjne odmiany Mercia z genami niewrażliwości na fotoperiod (Ppd-A1) oraz formy kontrolne wrażliwe na długość dnia (ppd-A1). Doświadczenie przeprowadzono w Gospodarstwie Doświadczalnym w Czesławicach. Analizowano
Externí odkaz:
https://doaj.org/article/0e62909ba8ca4fe7967adedac2ba8ec1
Autor:
P J Worland, W.F. De Azevedo, H J Mueller-Dieckmann, Sung-Hou Kim, E Sausville, Ursula Schulze-Gahmen
Publikováno v:
Proceedings of the National Academy of Sciences. 93:2735-2740
The central role of cyclin-dependent kinases (CDKs) in cell cycle regulation makes them a promising target for studying inhibitory molecules that can modify the degree of cell proliferation. The discovery of specific inhibitors of CDKs such as polyhy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1424399b0d50cc5d4e9f987d4f1f48cf
https://doi.org/10.1073/pnas.93.7.2735
https://doi.org/10.1073/pnas.93.7.2735
Autor:
B, Carlson, T, Lahusen, S, Singh, A, Loaiza-Perez, P J, Worland, R, Pestell, C, Albanese, E A, Sausville, A M, Senderowicz
Publikováno v:
Cancer research. 59(18)
Flavopiridol is a novel flavonoid that induces cell cycle arrest at different stages of the cell cycle because of the inhibition of cyclin-dependent kinases (cdks). In previous studies from our laboratory, (B. A. Carlson et al., Cancer Res., 56: 2973
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1fc942b6ba542d319c4b095c59fd64b2
https://pubmed.ncbi.nlm.nih.gov/10493518
https://pubmed.ncbi.nlm.nih.gov/10493518
Publikováno v:
Cancer research. 56(13)
Flavopiridol (L86-8275), a N-methylpiperidinyl, chlorophenyl flavone, can inhibit cell cycle progression in either G1 or G2 and is a potent cyclin-dependent kinase (CDK) 1 inhibitor. In this study, we used MCF-7 breast carcinoma cells that are wild t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::efbaffbcd2b35fb1158d5f4a18dd44fa
https://pubmed.ncbi.nlm.nih.gov/8674031
https://pubmed.ncbi.nlm.nih.gov/8674031
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 6(8)
7-Hydroxystaurosporine (UCN-01) is a potent inhibitor of protein kinase C (PKC) isozymes alpha, beta, and gamma [Seynaeve et al., Mol. Pharmacol, 45: 1207-1214, 1994] that also has antitumor effects in vivo. To determine whether inhibition of PKC can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1f5a4ae75e5f0f913474fbc778afbe3f
https://pubmed.ncbi.nlm.nih.gov/8547221
https://pubmed.ncbi.nlm.nih.gov/8547221
Publikováno v:
Molecular pharmacology. 45(6)
UCN-01 (7-hydroxystaurosporine) has been demonstrated to be a potent inhibitor of tumor cell growth both in cell culture and with in vivo xenograft models. The ability of UCN-01 to inhibit the kinase activity of recombinant protein kinase C (PKC) iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3b332709c458bdddf21b3e9cd7bf2f8
https://pubmed.ncbi.nlm.nih.gov/8022414
https://pubmed.ncbi.nlm.nih.gov/8022414
Publikováno v:
Biochemical pharmacology. 46(10)
The flavone L86-8275 [(-)cis-5,7-dihydroxy-2-(2-chlorophenyl)-8-[4-(3-hydroxy-1-methyl)- piperidinyl]-4H-1-benzopyran-4-one] delayed the progression of aphidicolin-synchronized MDA-468 breast carcinoma cells through S phase and prevented progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a10da8e88075ed646c99feade0e518ab
https://pubmed.ncbi.nlm.nih.gov/8250970
https://pubmed.ncbi.nlm.nih.gov/8250970
Publikováno v:
Cancer research. 53(9)
UCN-01 is a derivative of staurosporine, initially developed as a potentially selective inhibitor of the Ca(2+)- and phospholipid-dependent protein kinase C, but with the capacity to inhibit a number of tyrosine and serine/threonine kinases. UCN-01 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0602218415cd293fef9949a4162d4dc7
https://pubmed.ncbi.nlm.nih.gov/7683251
https://pubmed.ncbi.nlm.nih.gov/7683251
Publikováno v:
Cancer research. 50(23)
Clonal cell lines were derived from rat liver epithelial cells following their transformation with either v-raf or v-raf/v-myc. Cells transformed with v-raf alone showed reduced tumor incidence and tumor growth rates when implanted into nude mice, co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5dc96ce326d811853e8322b9364de4f7
https://pubmed.ncbi.nlm.nih.gov/1701345
https://pubmed.ncbi.nlm.nih.gov/1701345