Zobrazeno 1 - 10
of 113
pro vyhledávání: '"P J Rice"'
Autor:
Jack B. Roberts, Olivia L.G. Boldvig, Guillaume Aubourg, S. Tanishq Kanchenapally, David J. Deehan, Sarah J. Rice, John Loughlin
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-13 (2024)
Abstract Background Transitioning from a genetic association signal to an effector gene and a targetable molecular mechanism requires the application of functional fine-mapping tools such as reporter assays and genome editing. In this report, we unde
Externí odkaz:
https://doaj.org/article/9c31b31140bb46b0badb848d45713eab
Autor:
Emily Carter, Elizabeth J Elliott, Sue Thomas, Jadnah Davies, Thomas Stubbs, Lauren J Rice, Alexandra L C Martiniuk, Lisa Cannon, Josephine Chidinma Okurame, Habiba Naanai, Mudge Bedford
Publikováno v:
BMJ Open, Vol 14, Iss 7 (2024)
Objectives This scoping review aimed to identify and critically appraise resources for health professionals to identify, diagnose, refer, and support individuals with fetal alcohol spectrum disorder (FASD)—including the extent to which the resource
Externí odkaz:
https://doaj.org/article/c7bfa4658f1c497b86a8fc25030b41ce
Autor:
Alexandra L. Mitchell, Sung Hoon Lee, David J. McEnroe, Eric L. Null, Daniel A. Sternquist, Kathryn A. Hufziger, Brian J. Rice, Alex Scrimshire, Paul A. Bingham, Timothy M. Gross
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Glasses with high antimicrobial efficacy were developed in the Fe2O3-CuO-P2O5 ternary system to mitigate fomite-mediated transmission of infectious diseases in high-risk settings such as hospitals, daycares, and nursing homes. Binary CuO-P2O
Externí odkaz:
https://doaj.org/article/77627ca4df674a53ae6eca0b1cc4189d
Autor:
Javiera-Violeta Durán Kairies, Emma J Rice, Sterling Stutz, Sharon W Y Tan, Anne Simard, Heather Ross, Angela Mashford-Pringle
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0302816 (2024)
Cardiovascular disease is a leading cause of death worldwide, with disproportionate impacts on Indigenous Peoples in Canada. In Spring 2022, a land-based learning program was piloted and evaluated as an Indigenous cultural safety training for profess
Externí odkaz:
https://doaj.org/article/c0c4fd4c06434a13a079ec2a5ceb4e07
Autor:
Marissa Mock, Alex W. Jacobitz, Christopher James Langmead, Athena Sudom, Daniel Yoo, Sara C. Humphreys, Mai Alday, Larysa Alekseychyk, Nicolas Angell, Vivian Bi, Hannah Catterall, Chen-Chun Chen, Hui-Ting Chou, Kip P. Conner, Kevin D. Cook, Ana R. Correia, Andrew Dykstra, Sudipa Ghimire-Rijal, Kevin Graham, Peter Grandsard, Joon Huh, John O. Hui, Mani Jain, Victoria Jann, Lei Jia, Sheree Johnstone, Neelam Khanal, Carl Kolvenbach, Linda Narhi, Rupa Padaki, Emma M. Pelegri-O’Day, Wei Qi, Vladimir Razinkov, Austin J. Rice, Richard Smith, Christopher Spahr, Jennitte Stevens, Yax Sun, Veena A. Thomas, Sarah van Driesche, Robert Vernon, Victoria Wagner, Kenneth W. Walker, Yangjie Wei, Dwight Winters, Melissa Yang, Iain D. G. Campuzano
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTBiologic drug discovery pipelines are designed to deliver protein therapeutics that have exquisite functional potency and selectivity while also manifesting biophysical characteristics suitable for manufacturing, storage, and convenient admin
Externí odkaz:
https://doaj.org/article/c7e86c82a6684b888888da7d561e8891
Autor:
Ameya Harmalkar, Roshan Rao, Yuxuan Richard Xie, Jonas Honer, Wibke Deisting, Jonas Anlahr, Anja Hoenig, Julia Czwikla, Eva Sienz-Widmann, Doris Rau, Austin J. Rice, Timothy P. Riley, Danqing Li, Hannah B. Catterall, Christine E. Tinberg, Jeffrey J. Gray, Kathy Y. Wei
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTOver the last three decades, the appeal for monoclonal antibodies (mAbs) as therapeutics has been steadily increasing as evident with FDA’s recent landmark approval of the 100th mAb. Unlike mAbs that bind to single targets, multispecific bi
Externí odkaz:
https://doaj.org/article/f28435022c594bb495320039c11e0b93
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-13 (2023)
Abstract Background Investigation of cartilage and chondrocytes has revealed that the osteoarthritis risk marked by the independent DNA variants rs11583641 and rs1046934 mediate their effects by decreasing the methylation status of CpG dinucleotides
Externí odkaz:
https://doaj.org/article/d3db7e5027b6495781391d28190ee6fc
Autor:
Adriana K. Alexander, Edward J. Rice, Jelena Lujic, Leah E. Simon, Stephanie Tanis, Gilad Barshad, Lina Zhu, Jyoti Lama, Paula E. Cohen, Charles G. Danko
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
During spermatogenic meiosis, chromatin changes due to transcription, homologous recombination, and chromosome synapsis must be coordinated. Here they show that A-MYC and BRDT regulate release of paused RNA PolII to induce a transcriptional burst dur
Externí odkaz:
https://doaj.org/article/6364da4fd446454e9bcfa2f349fb1200
Autor:
Brooke A. Marks, Ilissa M. Pipia, Chinatsu Mukai, Sachi Horibata, Edward J. Rice, Charles G. Danko, Scott A. Coonrod
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background Rearranged during transfection (RET) tyrosine kinase signaling has been previously implicated in endocrine resistant breast cancer, however the mechanism by which this signaling cascade promotes resistance is currently not well de
Externí odkaz:
https://doaj.org/article/a513dee986ef4a7189c12bc44866baf1
Autor:
Richard S. Ayikpoe, Chengyou Shi, Alexander J. Battiste, Sara M. Eslami, Sangeetha Ramesh, Max A. Simon, Ian R. Bothwell, Hyunji Lee, Andrew J. Rice, Hengqian Ren, Qiqi Tian, Lonnie A. Harris, Raymond Sarksian, Lingyang Zhu, Autumn M. Frerk, Timothy W. Precord, Wilfred A. van der Donk, Douglas A. Mitchell, Huimin Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Ribosomally synthesized and post-translationally modified peptides are a source of antimicrobials. Here, the authors report a platform for the rapid evaluation and characterization of biosynthetic gene clusters that enables the identification of 30 s
Externí odkaz:
https://doaj.org/article/0a3ed6c619eb4863808dafe364241e8d